Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 119774049

GI number: 119774049

Start: 1101444

End: 1103081

Strand: Reverse

Name: pgi

Synonym: Sama_0912

Alternate gene names: 119774049

Gene position: 1103081-1101444 (Counterclockwise)

Preceding gene: 119774050

Following gene: 119774048

Centisome position: 25.62

GC content: 52.44

Gene sequence:

>1638_bases
ATGAGTCGAGTGACCAATACTCCTGAATGGCAGAAACTGAAAGAATATTCCAACAAACTGCCTCATATGCGTGAACTTTT
TGCGACTGACAGCGCACGTTTCGACAAAATGTCGCTGAAAGCCTGTGGTCTGTTTCTGGATTACTCCAAAAACCGCGTAA
CAGAAGTCGTGCTGGGTGCCTTGTTCGATTTGGCAAAGCAAGCTCAGCTAGAAGCCCGCATCAACGCCATGTTCGCCGGT
GATATTATCAACACCACTGAAAAGCGTGCCGTACTGCACACCGCACTGCGTGCGCCAAATGATGCTGTAGTTGAAGTGGA
TGGTGTCAATGTGGTGCCGGAAGTCCATGCTACTCTGGATAAAATTGAATCCTTCGTTGCCTCAATTACCTCTGGCGAAT
GGCGCGGTTACACGGGTAAAGCTATCACCGATATTGTCAGCATAGGTATTGGCGGCTCATTCCTCGGGCCCAAAATTGTC
ACCCAGGCGCTGCGTCCATACTGGACAGGCAAGCTGAACTGTCACTTTGTTGCCAACGTGGATGCCACCTCGCTGGTTGA
AAAGCTCAAGCTGGTCGACCCGGAAACAACTCTGTTCCTGATGTCATCCAAGTCGTTTGGCACTCAGGAAACCCTCACCA
ATACCCTGAGTGCCCGCGACTGGTTCCTGCAAAGCGGTGCTTCTCAGGCTGATGTAGCCAAACACTTTGCCGCTGTGACC
TCCAACGTGGCCAAGGCGACTGATTTCGGTATCGATGAAGCCAATGTCTTCCCAATGTGGGACTGGGTTGGTGGTCGCTA
CTCACTCTGGTCTGCCATTGGTCTGCCTATTGCACTGATGGTTGGCATGGATAACTACCGGGCGCTGCTCGCCGGTGCCC
GCAGTATGGACGAACACTTCACCTCGGCGCCGCTGGCTGAGAACATGCCGGTGATTATGGGTCTGCTGTCGGTGTGGTAT
GGCAACTTTTTCAATGCCCAGTCACACGTAGTGCTCACCTATGACCACTACCTGCGAGGTTTGCCCGCTTACTTCCAGCA
GCTTGACATGGAAAGTAACGGCAAGTCTGCCATGATGGATGGCGAAACCGTGGATTTCAGCACTGGCCCGGTTATCTGGG
GCGGTGAAGGTACCAATGGTCAGCATGCCTATCACCAGTTGTTACATCAGGGCACTGCACTCATTCCTGCCGACTTCATT
ATGCCGCTACAAAGTCATAATCCGCTGGGTGAACATCATGTGCAGCTTGCATCCAATTGCTTCGGACAAACCCAGGCTTT
GATGCAGGGGCGCACCTACGAAGAAGCCTTGGCTGAACTTGCAGCAAGCAATCTCAGTGATGATGAGAAGAGTCTTATCG
CCCGTCATAAGGTTATGGAGGGTAACAAGCCGAGCAACACCCTGCTGATGGACAAACTGACACCTTCCACATTGGGTGCA
CTGATAGCGCTGTACGAGCACAGAACCTTTGTTCAGGGTGTGATTTGGGATATTAACTCTTTCGACCAGTGGGGCGTGGA
GCTGGGAAAAACGCTGGGCAATGACGTGCTGGCGCGCCTGACCGCCGATGAGGATGCCAGCGCACTGGACTCCTCCAGTA
ACGCGCTCATTAATTTGTTCCGCAAAGGACAAATTTAG

Upstream 100 bases:

>100_bases
GAAAAGCTGGCCGAAGGGATCCGTAACTTCGCCATCGATCAAGGCAAACTGGAAGAGATGCTCAAGGCTAAACTGGCCTG
ATAACGCGGGGAAGCAACGA

Downstream 100 bases:

>100_bases
TCAGATGTTTTCTCTTTAATAATCAAAGGCCGATAATTTATCGGCCTTTTTATTTAAATTCAGTCGGTTATTTAATCTTC
TACGAAGATCATCCAAGTTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSRVTNTPEWQKLKEYSNKLPHMRELFATDSARFDKMSLKACGLFLDYSKNRVTEVVLGALFDLAKQAQLEARINAMFAG
DIINTTEKRAVLHTALRAPNDAVVEVDGVNVVPEVHATLDKIESFVASITSGEWRGYTGKAITDIVSIGIGGSFLGPKIV
TQALRPYWTGKLNCHFVANVDATSLVEKLKLVDPETTLFLMSSKSFGTQETLTNTLSARDWFLQSGASQADVAKHFAAVT
SNVAKATDFGIDEANVFPMWDWVGGRYSLWSAIGLPIALMVGMDNYRALLAGARSMDEHFTSAPLAENMPVIMGLLSVWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSAMMDGETVDFSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLQSHNPLGEHHVQLASNCFGQTQALMQGRTYEEALAELAASNLSDDEKSLIARHKVMEGNKPSNTLLMDKLTPSTLGA
LIALYEHRTFVQGVIWDINSFDQWGVELGKTLGNDVLARLTADEDASALDSSSNALINLFRKGQI

Sequences:

>Translated_545_residues
MSRVTNTPEWQKLKEYSNKLPHMRELFATDSARFDKMSLKACGLFLDYSKNRVTEVVLGALFDLAKQAQLEARINAMFAG
DIINTTEKRAVLHTALRAPNDAVVEVDGVNVVPEVHATLDKIESFVASITSGEWRGYTGKAITDIVSIGIGGSFLGPKIV
TQALRPYWTGKLNCHFVANVDATSLVEKLKLVDPETTLFLMSSKSFGTQETLTNTLSARDWFLQSGASQADVAKHFAAVT
SNVAKATDFGIDEANVFPMWDWVGGRYSLWSAIGLPIALMVGMDNYRALLAGARSMDEHFTSAPLAENMPVIMGLLSVWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSAMMDGETVDFSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLQSHNPLGEHHVQLASNCFGQTQALMQGRTYEEALAELAASNLSDDEKSLIARHKVMEGNKPSNTLLMDKLTPSTLGA
LIALYEHRTFVQGVIWDINSFDQWGVELGKTLGNDVLARLTADEDASALDSSSNALINLFRKGQI
>Mature_544_residues
SRVTNTPEWQKLKEYSNKLPHMRELFATDSARFDKMSLKACGLFLDYSKNRVTEVVLGALFDLAKQAQLEARINAMFAGD
IINTTEKRAVLHTALRAPNDAVVEVDGVNVVPEVHATLDKIESFVASITSGEWRGYTGKAITDIVSIGIGGSFLGPKIVT
QALRPYWTGKLNCHFVANVDATSLVEKLKLVDPETTLFLMSSKSFGTQETLTNTLSARDWFLQSGASQADVAKHFAAVTS
NVAKATDFGIDEANVFPMWDWVGGRYSLWSAIGLPIALMVGMDNYRALLAGARSMDEHFTSAPLAENMPVIMGLLSVWYG
NFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSAMMDGETVDFSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIM
PLQSHNPLGEHHVQLASNCFGQTQALMQGRTYEEALAELAASNLSDDEKSLIARHKVMEGNKPSNTLLMDKLTPSTLGAL
IALYEHRTFVQGVIWDINSFDQWGVELGKTLGNDVLARLTADEDASALDSSSNALINLFRKGQI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=552, Percent_Identity=50, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI296080693, Length=552, Percent_Identity=46.7391304347826, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=52.7777777777778, Blast_Score=595, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71996708, Length=539, Percent_Identity=51.39146567718, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71996703, Length=539, Percent_Identity=51.39146567718, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=49.7267759562842, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24651916, Length=542, Percent_Identity=53.1365313653137, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24651914, Length=542, Percent_Identity=53.1365313653137, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI17737445, Length=542, Percent_Identity=53.1365313653137, Blast_Score=575, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SHEAM (A1S413)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926789.1
- ProteinModelPortal:   A1S413
- SMR:   A1S413
- STRING:   A1S413
- GeneID:   4603164
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0912
- NMPDR:   fig|326297.7.peg.859
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   A1S413
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59792; Mature: 59660

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 351-351 ACT_SITE 382-382 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVTNTPEWQKLKEYSNKLPHMRELFATDSARFDKMSLKACGLFLDYSKNRVTEVVLGA
CCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHH
LFDLAKQAQLEARINAMFAGDIINTTEKRAVLHTALRAPNDAVVEVDGVNVVPEVHATLD
HHHHHHHHHHHHHHHHEEECCHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
KIESFVASITSGEWRGYTGKAITDIVSIGIGGSFLGPKIVTQALRPYWTGKLNCHFVANV
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCHHCCCCEEEEEEECC
DATSLVEKLKLVDPETTLFLMSSKSFGTQETLTNTLSARDWFLQSGASQADVAKHFAAVT
CHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SNVAKATDFGIDEANVFPMWDWVGGRYSLWSAIGLPIALMVGMDNYRALLAGARSMDEHF
HHHHHHHHCCCCCCCCEEEHHCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
TSAPLAENMPVIMGLLSVWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSAMMD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCCEEEC
GETVDFSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLQSHNPLGEHHVQLASNC
CCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHH
FGQTQALMQGRTYEEALAELAASNLSDDEKSLIARHKVMEGNKPSNTLLMDKLTPSTLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
LIALYEHRTFVQGVIWDINSFDQWGVELGKTLGNDVLARLTADEDASALDSSSNALINLF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHH
RKGQI
HCCCC
>Mature Secondary Structure 
SRVTNTPEWQKLKEYSNKLPHMRELFATDSARFDKMSLKACGLFLDYSKNRVTEVVLGA
CCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHH
LFDLAKQAQLEARINAMFAGDIINTTEKRAVLHTALRAPNDAVVEVDGVNVVPEVHATLD
HHHHHHHHHHHHHHHHEEECCHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
KIESFVASITSGEWRGYTGKAITDIVSIGIGGSFLGPKIVTQALRPYWTGKLNCHFVANV
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCHHCCCCEEEEEEECC
DATSLVEKLKLVDPETTLFLMSSKSFGTQETLTNTLSARDWFLQSGASQADVAKHFAAVT
CHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SNVAKATDFGIDEANVFPMWDWVGGRYSLWSAIGLPIALMVGMDNYRALLAGARSMDEHF
HHHHHHHHCCCCCCCCEEEHHCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
TSAPLAENMPVIMGLLSVWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSAMMD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCCEEEC
GETVDFSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLQSHNPLGEHHVQLASNC
CCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHH
FGQTQALMQGRTYEEALAELAASNLSDDEKSLIARHKVMEGNKPSNTLLMDKLTPSTLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
LIALYEHRTFVQGVIWDINSFDQWGVELGKTLGNDVLARLTADEDASALDSSSNALINLF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHH
RKGQI
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA