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The map label for this gene is pepQ [H]

Identifier: 119773822

GI number: 119773822

Start: 844739

End: 846538

Strand: Reverse

Name: pepQ [H]

Synonym: Sama_0684

Alternate gene names: 119773822

Gene position: 846538-844739 (Counterclockwise)

Preceding gene: 119773825

Following gene: 119773821

Centisome position: 19.66

GC content: 57.56

Gene sequence:

>1800_bases
ATGTCAGCAGTCGCCAGCAGTGAAATCTCCAAGCGCCTCGATGCCATTCGCGTTGAAATGGCCGCAAGTAAACTCGATGC
CTTCATCATCCCCCGCGCCGACGAATATCTTGGGGAATACGTGCCTGAGCATAATGAGCGTCTTCATTGGGCCACCGGCT
TTACTGGCTCTGCCGGTATGGCGATTGTGATGAAAGAGACCGCCGCCATCTTCGTCGACGGCCGCTACACTGTGCAGGTA
CGCGATCAGGTAGACGAACGCCTTTACGCCTATGAGAGCCTGACCGATACGCCCCAGCCTCAGTATCTTGCGGAAACCCT
GAGCGAAGGCGCCCGGGTTGGATTCGATGCCCGTATGCATACCCTGGCCTGGTTTGAACAGGCCAAGGCCGTGCTGGATA
AGGCCGGTATAGAGCTCGTTGCCGTGAGCGAAAACCCCATTGATAAGCACTGGCACGATCGCCCCGTGCCGGAAATAAAA
CCCCTGCACCTCTTCAGTGATGCCGATGCGGGCAAGACCAGCGCCCAAAAACGTGCCGAAACCGGCCTTTTGGTGAAGAA
AGCCGGTGGCGATGTCGCGCTTATTACCGCGCTTGATTCCTTCTGCTGGCTGCTCAATATCCGCGGCTTTGATGTGCCCA
GATTGCCTGTGGTGCTGGGCTGTGCCCTGCTGTGGCAGGATGGCCGTATGCAGCTCTTTGTGGATACCGCCAAAGTTCCT
GAGGGATTCGCCGCCCATGTGGGCGAAGGCGTGAGTGTGCACGCTGAATCTGAACTCGAGCTCGCCCTTAAGGAGCTCAC
TGGCAAGAAGCTACTGGCCGACCCCAACAGTGCCAATGCAGCAAGCCAGCTCACTGCCCGTAACGCCGGTGCCAAACTCG
TTGCGGCCATGGACGTGGTCGCCCTGCCAAAGGCAGCCAAAAATGATTCTGAGCTTAAAGGCATGCGCGAATGCCATGTG
CGCGACGGCGTGGCCGTGAGTCGTTTCCTTGCCTGGCTCGACAATGAAGTGGCTTCGGGCCGCCTGTACGATGAAGCCCA
GCTGGCCGATAAGCTTGAGAGCTTCCGTCTGGAAGACCCTCGCTACCGTGAGCCAAGCTTTGACACTATTTCTGCCGCCG
GTGCCAATGCCGCCATGTGCCATTACAACCACAATAATGGCACTCCGGCAAAACTGACCATGAACAGCATCTATCTGGTG
GACTCGGGCGCCCAATATCTGGATGGCACCACAGATGTCACCCGCACCCTGGCTATCGGTGAAGTCACCGACGAGCAAAA
GAAAATGGTTACCCTGGTACTCAAGGGCCATATTGCACTGGACTGCGCCCGTTTCCCCAAAGGCACCACAGGCCAGCAGC
TGGATGCCTTCGCCCGCCAGTACCTGTGGCAACATGGCTTTGACTATGACCACGGTACAGGCCACGGAGTTGGCCACTTC
CTGAGTGTACATGAAGGACCGCAACGCATCGCCAAAAACAGCAATGCAGTGGCACTGCTGCCCGGTATGGTGGTATCCAA
CGAGCCCGGCTACTACCGCGCCAATGGCTTTGGTATTCGCATCGAAAACCTGATTGTGGTGCGCCACTGCGAGGCGCTGA
AAGGCGCCGAGCGCGAAACCTATGAGTTTGAAGCCCTCACCCTTATCCCCATCGATACCCGTCTTATCGACAAGGCGCTG
CTGACAGAGGCCGAGGTGAATTGGCTCAACCGTTACCACAGCAAGGTATACAGCACCCTGTCACCACTGATGTCCGGTGA
CGAGCTGACCTGGCTGACCAAGGCCACCCAAGCTATCTGA

Upstream 100 bases:

>100_bases
TAAGCCACGGGACAGTACCCGGGCAAATTACCGGTGCTCAAGCACAAGTACGCAAACATCAGTACCCACTCACAAGCAAA
ACGTCAGGAAAAGGTTACCC

Downstream 100 bases:

>100_bases
TAAAAAGCGCCTGCGGGCGCTTTTTTATTACCCCAAAACTCCGGAAAACAACCAGAAGCGCAAATCCACCAAAACAGAGG
AGCCCTATGTTCGCCGTTAT

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MSAVASSEISKRLDAIRVEMAASKLDAFIIPRADEYLGEYVPEHNERLHWATGFTGSAGMAIVMKETAAIFVDGRYTVQV
RDQVDERLYAYESLTDTPQPQYLAETLSEGARVGFDARMHTLAWFEQAKAVLDKAGIELVAVSENPIDKHWHDRPVPEIK
PLHLFSDADAGKTSAQKRAETGLLVKKAGGDVALITALDSFCWLLNIRGFDVPRLPVVLGCALLWQDGRMQLFVDTAKVP
EGFAAHVGEGVSVHAESELELALKELTGKKLLADPNSANAASQLTARNAGAKLVAAMDVVALPKAAKNDSELKGMRECHV
RDGVAVSRFLAWLDNEVASGRLYDEAQLADKLESFRLEDPRYREPSFDTISAAGANAAMCHYNHNNGTPAKLTMNSIYLV
DSGAQYLDGTTDVTRTLAIGEVTDEQKKMVTLVLKGHIALDCARFPKGTTGQQLDAFARQYLWQHGFDYDHGTGHGVGHF
LSVHEGPQRIAKNSNAVALLPGMVVSNEPGYYRANGFGIRIENLIVVRHCEALKGAERETYEFEALTLIPIDTRLIDKAL
LTEAEVNWLNRYHSKVYSTLSPLMSGDELTWLTKATQAI

Sequences:

>Translated_599_residues
MSAVASSEISKRLDAIRVEMAASKLDAFIIPRADEYLGEYVPEHNERLHWATGFTGSAGMAIVMKETAAIFVDGRYTVQV
RDQVDERLYAYESLTDTPQPQYLAETLSEGARVGFDARMHTLAWFEQAKAVLDKAGIELVAVSENPIDKHWHDRPVPEIK
PLHLFSDADAGKTSAQKRAETGLLVKKAGGDVALITALDSFCWLLNIRGFDVPRLPVVLGCALLWQDGRMQLFVDTAKVP
EGFAAHVGEGVSVHAESELELALKELTGKKLLADPNSANAASQLTARNAGAKLVAAMDVVALPKAAKNDSELKGMRECHV
RDGVAVSRFLAWLDNEVASGRLYDEAQLADKLESFRLEDPRYREPSFDTISAAGANAAMCHYNHNNGTPAKLTMNSIYLV
DSGAQYLDGTTDVTRTLAIGEVTDEQKKMVTLVLKGHIALDCARFPKGTTGQQLDAFARQYLWQHGFDYDHGTGHGVGHF
LSVHEGPQRIAKNSNAVALLPGMVVSNEPGYYRANGFGIRIENLIVVRHCEALKGAERETYEFEALTLIPIDTRLIDKAL
LTEAEVNWLNRYHSKVYSTLSPLMSGDELTWLTKATQAI
>Mature_598_residues
SAVASSEISKRLDAIRVEMAASKLDAFIIPRADEYLGEYVPEHNERLHWATGFTGSAGMAIVMKETAAIFVDGRYTVQVR
DQVDERLYAYESLTDTPQPQYLAETLSEGARVGFDARMHTLAWFEQAKAVLDKAGIELVAVSENPIDKHWHDRPVPEIKP
LHLFSDADAGKTSAQKRAETGLLVKKAGGDVALITALDSFCWLLNIRGFDVPRLPVVLGCALLWQDGRMQLFVDTAKVPE
GFAAHVGEGVSVHAESELELALKELTGKKLLADPNSANAASQLTARNAGAKLVAAMDVVALPKAAKNDSELKGMRECHVR
DGVAVSRFLAWLDNEVASGRLYDEAQLADKLESFRLEDPRYREPSFDTISAAGANAAMCHYNHNNGTPAKLTMNSIYLVD
SGAQYLDGTTDVTRTLAIGEVTDEQKKMVTLVLKGHIALDCARFPKGTTGQQLDAFARQYLWQHGFDYDHGTGHGVGHFL
SVHEGPQRIAKNSNAVALLPGMVVSNEPGYYRANGFGIRIENLIVVRHCEALKGAERETYEFEALTLIPIDTRLIDKALL
TEAEVNWLNRYHSKVYSTLSPLMSGDELTWLTKATQAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=622, Percent_Identity=37.459807073955, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI93141226, Length=601, Percent_Identity=33.9434276206323, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI264681565, Length=622, Percent_Identity=35.8520900321543, Blast_Score=340, Evalue=3e-93,
Organism=Escherichia coli, GI1788728, Length=248, Percent_Identity=31.4516129032258, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=595, Percent_Identity=36.3025210084034, Blast_Score=350, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI25149105, Length=606, Percent_Identity=31.1881188118812, Blast_Score=273, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6322999, Length=661, Percent_Identity=31.0136157337368, Blast_Score=298, Evalue=2e-81,
Organism=Drosophila melanogaster, GI17137632, Length=593, Percent_Identity=38.1112984822934, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161078230, Length=590, Percent_Identity=28.4745762711864, Blast_Score=249, Evalue=6e-66,
Organism=Drosophila melanogaster, GI21357287, Length=590, Percent_Identity=28.4745762711864, Blast_Score=249, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65779; Mature: 65648

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVASSEISKRLDAIRVEMAASKLDAFIIPRADEYLGEYVPEHNERLHWATGFTGSAGM
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCE
AIVMKETAAIFVDGRYTVQVRDQVDERLYAYESLTDTPQPQYLAETLSEGARVGFDARMH
EEEEEECEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHH
TLAWFEQAKAVLDKAGIELVAVSENPIDKHWHDRPVPEIKPLHLFSDADAGKTSAQKRAE
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHH
TGLLVKKAGGDVALITALDSFCWLLNIRGFDVPRLPVVLGCALLWQDGRMQLFVDTAKVP
CCEEEEECCCCEEEEHHHHHHHHEEECCCCCCCCHHHHHHHHHEECCCCEEEEEECCCCC
EGFAAHVGEGVSVHAESELELALKELTGKKLLADPNSANAASQLTARNAGAKLVAAMDVV
CCHHHHCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHCCCCCEEHHHHHHH
ALPKAAKNDSELKGMRECHVRDGVAVSRFLAWLDNEVASGRLYDEAQLADKLESFRLEDP
HCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCC
RYREPSFDTISAAGANAAMCHYNHNNGTPAKLTMNSIYLVDSGAQYLDGTTDVTRTLAIG
CCCCCCCCCHHCCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCHHCCCCHHHHHEEEEC
EVTDEQKKMVTLVLKGHIALDCARFPKGTTGQQLDAFARQYLWQHGFDYDHGTGHGVGHF
CCCCHHHHEEEEEEECCEEEEHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LSVHEGPQRIAKNSNAVALLPGMVVSNEPGYYRANGFGIRIENLIVVRHCEALKGAERET
EECCCCHHHHHCCCCEEEEECCEEEECCCCEEEECCEEEEEEEEEEEEEHHHHCCCCCCC
YEFEALTLIPIDTRLIDKALLTEAEVNWLNRYHSKVYSTLSPLMSGDELTWLTKATQAI
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCC
>Mature Secondary Structure 
SAVASSEISKRLDAIRVEMAASKLDAFIIPRADEYLGEYVPEHNERLHWATGFTGSAGM
CCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCE
AIVMKETAAIFVDGRYTVQVRDQVDERLYAYESLTDTPQPQYLAETLSEGARVGFDARMH
EEEEEECEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHH
TLAWFEQAKAVLDKAGIELVAVSENPIDKHWHDRPVPEIKPLHLFSDADAGKTSAQKRAE
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHH
TGLLVKKAGGDVALITALDSFCWLLNIRGFDVPRLPVVLGCALLWQDGRMQLFVDTAKVP
CCEEEEECCCCEEEEHHHHHHHHEEECCCCCCCCHHHHHHHHHEECCCCEEEEEECCCCC
EGFAAHVGEGVSVHAESELELALKELTGKKLLADPNSANAASQLTARNAGAKLVAAMDVV
CCHHHHCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHCCCCCEEHHHHHHH
ALPKAAKNDSELKGMRECHVRDGVAVSRFLAWLDNEVASGRLYDEAQLADKLESFRLEDP
HCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCC
RYREPSFDTISAAGANAAMCHYNHNNGTPAKLTMNSIYLVDSGAQYLDGTTDVTRTLAIG
CCCCCCCCCHHCCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCHHCCCCHHHHHEEEEC
EVTDEQKKMVTLVLKGHIALDCARFPKGTTGQQLDAFARQYLWQHGFDYDHGTGHGVGHF
CCCCHHHHEEEEEEECCEEEEHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LSVHEGPQRIAKNSNAVALLPGMVVSNEPGYYRANGFGIRIENLIVVRHCEALKGAERET
EECCCCHHHHHCCCCEEEEECCEEEECCCCEEEECCEEEEEEEEEEEEEHHHHCCCCCCC
YEFEALTLIPIDTRLIDKALLTEAEVNWLNRYHSKVYSTLSPLMSGDELTWLTKATQAI
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]