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The map label for this gene is arcA [H]

Identifier: 119773739

GI number: 119773739

Start: 752820

End: 753536

Strand: Reverse

Name: arcA [H]

Synonym: Sama_0601

Alternate gene names: 119773739

Gene position: 753536-752820 (Counterclockwise)

Preceding gene: 119773743

Following gene: 119773737

Centisome position: 17.5

GC content: 51.19

Gene sequence:

>717_bases
ATGCAAAATCCGCACATTCTGATCGTAGAAGACGAAGCCGTTACCCGTAATACATTAAGAAGTATTTTTGAGGCCGAGGG
ATATGTGGTGACTGAGGCCAACGATGGCGCAGAAATGCATAAAGCCTTGCAGGAAAATAAAATAAACCTGGTGGTGATGG
ATATCAACCTGCCGGGTAAAAACGGTCTGTTGTTGGCACGCGAACTGCGTGAAATCAACAACATTGGCCTGATTTTCCTG
ACTGGCCGTGACAACGAAGTGGACAAGATCCTGGGTCTTGAAATTGGCGCGGACGATTATATTACCAAGCCGTTCAACCC
ACGTGAGCTGACCATTCGTGCCCGTAATCTTCTGACTCGCGTCAATAGCGCTGGCGCCGAAGTCGAAGAGAGAGCCGCGG
TCGAGGTTTATCGTTTCAATGACTGGAGCCTGGAAATCAACAGCCGTTCTCTGGTCAGCCCAACCGGTGAGTCTTACAAA
CTGCCACGCAGCGAATTCCGTGCCATGCTGCACTTCGTTGAAAACCCAGGCAAGATCCTGAGCCGCGCCGATCTTCTGAT
GAAGATGACAGGCCGTGAACTCAAGCCACACGACCGTACCGTAGACGTGACTATCCGTCGTATCCGCAAGCACTTCGAAA
GCCAGCCAGATACACCGGAAATCATCGCCACCATCCACGGTGAAGGCTATCGCTTCTGTGGTAACCTGGACGAATAA

Upstream 100 bases:

>100_bases
AGGTTATTTGGGTCTTGCCGGAATAAAAAGCAGGGCCTGGCTGACAGTTGGCCGACACACCCGATTAGCACAGATTTGTT
TTAAATTTAGGTACTTGATT

Downstream 100 bases:

>100_bases
GGGTTAACCCCTCTTTAATAAGCCAATCTTCGGATTGGCTTTTTTATTGGCTGCATTTTATTGATAAGCCAATAGCGTAA
TCTTTGAAATCCATAAGTAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKALQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEERAAVEVYRFNDWSLEINSRSLVSPTGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESQPDTPEIIATIHGEGYRFCGNLDE

Sequences:

>Translated_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKALQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEERAAVEVYRFNDWSLEINSRSLVSPTGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESQPDTPEIIATIHGEGYRFCGNLDE
>Mature_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKALQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEERAAVEVYRFNDWSLEINSRSLVSPTGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESQPDTPEIIATIHGEGYRFCGNLDE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=81.5126050420168, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.9184549356223, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=36.5957446808511, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=32.6086956521739, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=34.6320346320346, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=236, Percent_Identity=32.2033898305085, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=32.7433628318584, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786911, Length=231, Percent_Identity=32.034632034632, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=32.3144104803493, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=31.7391304347826, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=30.7359307359307, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27065; Mature: 27065

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKALQENKINLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSAGAEVEERAAVEVYRFNDWSLEINSRSLVSPTGESYKLPRSEFRAMLHFVENPGKIL
HHCCCCCCHHCCEEEEEEECCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHH
SRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESQPDTPEIIATIHGEGYRFCGNLDE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKALQENKINLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSAGAEVEERAAVEVYRFNDWSLEINSRSLVSPTGESYKLPRSEFRAMLHFVENPGKIL
HHCCCCCCHHCCEEEEEEECCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHH
SRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESQPDTPEIIATIHGEGYRFCGNLDE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]