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The map label for this gene is nadC [H]

Identifier: 119773512

GI number: 119773512

Start: 450088

End: 450945

Strand: Reverse

Name: nadC [H]

Synonym: Sama_0371

Alternate gene names: 119773512

Gene position: 450945-450088 (Counterclockwise)

Preceding gene: 119773522

Following gene: 119773511

Centisome position: 10.47

GC content: 53.96

Gene sequence:

>858_bases
ATGCTGGAAAATGACATCAGACTCTCAGTGAAAGCCGCATTGGATGAAGACCTTGGTCATGGCGATGCCAGCGCCGACAT
CACGGCTCAGCTCATCCCCGAAGATAGAATTGCCGAAGCAACACTGATTACCCGTGAAGAAGGGATCTTCTGTGGCAAAG
CCTGGGCAGAGCAAGTGTTCAATCAGCTGGGAGGCACAGTTGCCTTGCATTGGCACGTGGACGATGGCGATTGGGTAGTG
CCGAATCAAGTACTGTGTGAGTTGTCAGGCCCCGCGCGCGCCATACTTACAGGCGAGCGCACCGCAATGAACTTTATCCA
AACCCTGTCTGGTGTCGCCAGCCTGACCCGGGTTTACGTGGACAAGCTGGCCGGAACCGATTGCCGCCTGCTCGATACCC
GCAAGACCATACCGGGCCTGCGAACCGCCCAGAAGTATGCGGTAAGCTGTGGTGGCGGTAAAAATCATCGCATTGGTCTG
TACGATGCCTTCCTGATTAAAGAAAACCACATCATGGCCTGCGGTGGCATTAAAGCCGCCATAGATAAAGCAAGAACCTT
GCACCCGGACAAACCGGTTGAAGTGGAAGTCGAGTCTCTGGCCGAACTGACTGAAGCGCTGCAGGCAGGCAGCGACATCA
TTATGCTGGATAACTTTGACGTCACCATGATGATAGAAGCCGTAGCCATTAACGATGCATTCAAGGTGCAAGGTGGCGGT
GCCAAACTGGAAGTGTCGGGTAATGTCACCCTGGACACCCTCGGCGAGTTTGCCAAAACCGGTGTAGACTTCATCTCCGT
TGGTGCACTCACCAAACACGTCCGCGCAATGGATCTTTCCCTGAGGCTTAAACACTAA

Upstream 100 bases:

>100_bases
GGGCCAGCGCACATGGTATCCTTTTAGCATCAAGGCGTTCTCAAAATTACGCCCTAAAACCCGTTAGCAAGCCAGAATAA
GTAAAGCAAAGGACGTCGTC

Downstream 100 bases:

>100_bases
CAAGCTGACGTTTGGGCAGTTGCTTACAAGACATGAATCTTGCTCTGTAACTGCCCGGCTGTAATCTGCGATCACGTTTC
ATCTGAGCTGGACCTTTTGG

Product: nicotinate-nucleotide diphosphorylase (carboxylating)

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLENDIRLSVKAALDEDLGHGDASADITAQLIPEDRIAEATLITREEGIFCGKAWAEQVFNQLGGTVALHWHVDDGDWVV
PNQVLCELSGPARAILTGERTAMNFIQTLSGVASLTRVYVDKLAGTDCRLLDTRKTIPGLRTAQKYAVSCGGGKNHRIGL
YDAFLIKENHIMACGGIKAAIDKARTLHPDKPVEVEVESLAELTEALQAGSDIIMLDNFDVTMMIEAVAINDAFKVQGGG
AKLEVSGNVTLDTLGEFAKTGVDFISVGALTKHVRAMDLSLRLKH

Sequences:

>Translated_285_residues
MLENDIRLSVKAALDEDLGHGDASADITAQLIPEDRIAEATLITREEGIFCGKAWAEQVFNQLGGTVALHWHVDDGDWVV
PNQVLCELSGPARAILTGERTAMNFIQTLSGVASLTRVYVDKLAGTDCRLLDTRKTIPGLRTAQKYAVSCGGGKNHRIGL
YDAFLIKENHIMACGGIKAAIDKARTLHPDKPVEVEVESLAELTEALQAGSDIIMLDNFDVTMMIEAVAINDAFKVQGGG
AKLEVSGNVTLDTLGEFAKTGVDFISVGALTKHVRAMDLSLRLKH
>Mature_285_residues
MLENDIRLSVKAALDEDLGHGDASADITAQLIPEDRIAEATLITREEGIFCGKAWAEQVFNQLGGTVALHWHVDDGDWVV
PNQVLCELSGPARAILTGERTAMNFIQTLSGVASLTRVYVDKLAGTDCRLLDTRKTIPGLRTAQKYAVSCGGGKNHRIGL
YDAFLIKENHIMACGGIKAAIDKARTLHPDKPVEVEVESLAELTEALQAGSDIIMLDNFDVTMMIEAVAINDAFKVQGGG
AKLEVSGNVTLDTLGEFAKTGVDFISVGALTKHVRAMDLSLRLKH

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=250, Percent_Identity=35.2, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=282, Percent_Identity=64.5390070921986, Blast_Score=330, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6321162, Length=295, Percent_Identity=33.5593220338983, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30695; Mature: 30695

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIRLSVKAALDEDLGHGDASADITAQLIPEDRIAEATLITREEGIFCGKAWAEQVF
CCCCCEEEEEEEHHHHCCCCCCCCCCEEEEECCCCHHHHEEEEEECCCEEECHHHHHHHH
NQLGGTVALHWHVDDGDWVVPNQVLCELSGPARAILTGERTAMNFIQTLSGVASLTRVYV
HHCCCEEEEEEEECCCCEECCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
DKLAGTDCRLLDTRKTIPGLRTAQKYAVSCGGGKNHRIGLYDAFLIKENHIMACGGIKAA
HHHCCCCEEEEECHHCCCCCHHHHHHEEECCCCCCCEEEEEEEEEEECCCEEEECCHHHH
IDKARTLHPDKPVEVEVESLAELTEALQAGSDIIMLDNFDVTMMIEAVAINDAFKVQGGG
HHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCEEEECCCC
AKLEVSGNVTLDTLGEFAKTGVDFISVGALTKHVRAMDLSLRLKH
EEEEEECCEEHHHHHHHHHCCCCCEEHHHHHHHHHEEEEEEEECC
>Mature Secondary Structure
MLENDIRLSVKAALDEDLGHGDASADITAQLIPEDRIAEATLITREEGIFCGKAWAEQVF
CCCCCEEEEEEEHHHHCCCCCCCCCCEEEEECCCCHHHHEEEEEECCCEEECHHHHHHHH
NQLGGTVALHWHVDDGDWVVPNQVLCELSGPARAILTGERTAMNFIQTLSGVASLTRVYV
HHCCCEEEEEEEECCCCEECCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
DKLAGTDCRLLDTRKTIPGLRTAQKYAVSCGGGKNHRIGLYDAFLIKENHIMACGGIKAA
HHHCCCCEEEEECHHCCCCCHHHHHHEEECCCCCCCEEEEEEEEEEECCCEEEECCHHHH
IDKARTLHPDKPVEVEVESLAELTEALQAGSDIIMLDNFDVTMMIEAVAINDAFKVQGGG
HHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCEEEECCCC
AKLEVSGNVTLDTLGEFAKTGVDFISVGALTKHVRAMDLSLRLKH
EEEEEECCEEHHHHHHHHHCCCCCEEHHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]