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The map label for this gene is hisI

Identifier: 119717256

GI number: 119717256

Start: 3230666

End: 3231037

Strand: Reverse

Name: hisI

Synonym: Noca_3032

Alternate gene names: 119717256

Gene position: 3231037-3230666 (Counterclockwise)

Preceding gene: 119717257

Following gene: 119717255

Centisome position: 64.8

GC content: 72.04

Gene sequence:

>372_bases
GTGACCACCTTGGACCCCGCCATCGCCGGCCGGCTGAAGCGCAACCCGGACGGGCTGGTGCCCGCGGTCGTGCAGCAGCA
CGACACCGGCGAGGTGCTGATGCTGGGGTGGATGGACGACGAGGCGCTGGCCCGCACGCTGACGACCGGCCGGGCGACGT
ACTGGAGCCGCTCACGGCAGGAGTACTGGCTCAAGGGCGAGACCTCCGGGCACGTGCAGTGGGTCAAGGAGGTCCGGCTG
GACTGCGACGGCGACACGATCCTGGTGAAGGTCGACCAGGTCGGTGCCGCCTGCCACACCGGCGACCGCACCTGCTTCGA
CGCCGATCTGCTGTCCGGCGCCGACCGACCCGGCCCCGACGCCCGTGGCTGA

Upstream 100 bases:

>100_bases
TCGTCCAGCGCGGGCCGCACTCGGTGCTGGTCACCGAGGCCGGATCGGTCTACGCGGGCCTGCACGCGTCGTGGACCGCC
CAGCAGGGGACAATTCAGCA

Downstream 100 bases:

>100_bases
GCCGCGCCGTACCTTCGGCCCCGTCGTGCTCGGCGGCCTGACCGCCGGTGCCCTGGCGGCCATCGCCGGTGACCGGCCCG
CCGCCGCGGCGGACGGGGAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MTTLDPAIAGRLKRNPDGLVPAVVQQHDTGEVLMLGWMDDEALARTLTTGRATYWSRSRQEYWLKGETSGHVQWVKEVRL
DCDGDTILVKVDQVGAACHTGDRTCFDADLLSGADRPGPDARG

Sequences:

>Translated_123_residues
MTTLDPAIAGRLKRNPDGLVPAVVQQHDTGEVLMLGWMDDEALARTLTTGRATYWSRSRQEYWLKGETSGHVQWVKEVRL
DCDGDTILVKVDQVGAACHTGDRTCFDADLLSGADRPGPDARG
>Mature_122_residues
TTLDPAIAGRLKRNPDGLVPAVVQQHDTGEVLMLGWMDDEALARTLTTGRATYWSRSRQEYWLKGETSGHVQWVKEVRLD
CDGDTILVKVDQVGAACHTGDRTCFDADLLSGADRPGPDARG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=50, Blast_Score=102, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319819, Length=93, Percent_Identity=38.7096774193548, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_NOCSJ (A1SL49)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924221.1
- ProteinModelPortal:   A1SL49
- SMR:   A1SL49
- STRING:   A1SL49
- GeneID:   4596480
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3032
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   SGHYQIV
- BioCyc:   NSP35761:NOCA_3032-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13482; Mature: 13351

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLDPAIAGRLKRNPDGLVPAVVQQHDTGEVLMLGWMDDEALARTLTTGRATYWSRSRQ
CCCCCCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCHHCCCCCC
EYWLKGETSGHVQWVKEVRLDCDGDTILVKVDQVGAACHTGDRTCFDADLLSGADRPGPD
CEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEECHHHHCCCCCCCCC
ARG
CCC
>Mature Secondary Structure 
TTLDPAIAGRLKRNPDGLVPAVVQQHDTGEVLMLGWMDDEALARTLTTGRATYWSRSRQ
CCCCCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCHHCCCCCC
EYWLKGETSGHVQWVKEVRLDCDGDTILVKVDQVGAACHTGDRTCFDADLLSGADRPGPD
CEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEECHHHHCCCCCCCCC
ARG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA