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The map label for this gene is trpC

Identifier: 119717251

GI number: 119717251

Start: 3227954

End: 3228736

Strand: Reverse

Name: trpC

Synonym: Noca_3027

Alternate gene names: 119717251

Gene position: 3228736-3227954 (Counterclockwise)

Preceding gene: 119717253

Following gene: 119717250

Centisome position: 64.76

GC content: 73.56

Gene sequence:

>783_bases
ATGTCCGTGCTCGACGACATCGTGGCCGGCGTGCGGCTCGACCTGGCGGAGCGCGAGTCGGCGACCAGTCTCGCCGACCT
GCGGGCCGCGCTGGCCGACGTCGACCCGCCCCGTGACCCGATGCCGCACTTCCGGGCCGCCGGCTCGAGCGTGATCGCCG
AGGTCAAGCGGCGCAGCCCCAGCAAGGGCGACCTGGCCACGATCCCCGATCCGGCCGAGCTCGCCCGCAGCTACGCGGCG
GGTGGCGCTGCCGCGATCAGCGTGCTCACCGAGCAGCGCCGCTTCGGCGGCAGCCTCGCCGACCTGCGCGCGGTCCGGGC
CGCGGTCGACACCCCGATCCTGCGCAAGGACTTCATCGTCTCGAGCTACCAGGTCGTCGAGGCCCGGGCGGCCGGCGCGG
ACCTGGTGCTGCTGATCGTCGCGGCCCTCGACGACGACGACCTGCGCCGGCTCCACGACGAGGCCCGTGAGCTGGGCCTG
ACGGCGCTGGTCGAGGTCCACGACGAGCCCGAGACCGAGCGGGCCGTGGCCCTCGGTGCGGAGCTGGTCGGCGTGAACGC
TCGCAACCTGAAGACGCTCGCGATCCATGACGACACCTTCGGGCGGCTCGCGCCGCTGGTCCCCGACGATCGCGTCAAGG
TGGCCGAGTCGGGGATCTTCGGACCGGACGACGTGGCGCGGTTCGTGCGCGAGGGGGCCCGGGCCGTGCTCGTGGGCGAG
GCACTGGTGAAGGACGGCGACCCCGAGGGCGCAGTGCGCAGGATGACAGGAGTCGAGTCATGA

Upstream 100 bases:

>100_bases
CGCGGTCCGCGGGCCACCAGGGTCGTGACAGACTTCGAGTGCCGTACCGCCCTGATCCACCCCGATCGACCCTGCCCCGC
TGACTGGAGTGAGTGCCCGC

Downstream 100 bases:

>100_bases
CGACCAGGCCCGAGCGGACGACGACGTACGACGCGGACGCGCTCGGCTGGTTCGGCGGCCCCGCGGAGGGCTTCGGCGGG
CGGTTCATGCCCGAGGCCCT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSVLDDIVAGVRLDLAERESATSLADLRAALADVDPPRDPMPHFRAAGSSVIAEVKRRSPSKGDLATIPDPAELARSYAA
GGAAAISVLTEQRRFGGSLADLRAVRAAVDTPILRKDFIVSSYQVVEARAAGADLVLLIVAALDDDDLRRLHDEARELGL
TALVEVHDEPETERAVALGAELVGVNARNLKTLAIHDDTFGRLAPLVPDDRVKVAESGIFGPDDVARFVREGARAVLVGE
ALVKDGDPEGAVRRMTGVES

Sequences:

>Translated_260_residues
MSVLDDIVAGVRLDLAERESATSLADLRAALADVDPPRDPMPHFRAAGSSVIAEVKRRSPSKGDLATIPDPAELARSYAA
GGAAAISVLTEQRRFGGSLADLRAVRAAVDTPILRKDFIVSSYQVVEARAAGADLVLLIVAALDDDDLRRLHDEARELGL
TALVEVHDEPETERAVALGAELVGVNARNLKTLAIHDDTFGRLAPLVPDDRVKVAESGIFGPDDVARFVREGARAVLVGE
ALVKDGDPEGAVRRMTGVES
>Mature_259_residues
SVLDDIVAGVRLDLAERESATSLADLRAALADVDPPRDPMPHFRAAGSSVIAEVKRRSPSKGDLATIPDPAELARSYAAG
GAAAISVLTEQRRFGGSLADLRAVRAAVDTPILRKDFIVSSYQVVEARAAGADLVLLIVAALDDDDLRRLHDEARELGLT
ALVEVHDEPETERAVALGAELVGVNARNLKTLAIHDDTFGRLAPLVPDDRVKVAESGIFGPDDVARFVREGARAVLVGEA
LVKDGDPEGAVRRMTGVES

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=255, Percent_Identity=38.4313725490196, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=271, Percent_Identity=39.4833948339483, Blast_Score=166, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_NOCSJ (A1SL44)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924216.1
- ProteinModelPortal:   A1SL44
- SMR:   A1SL44
- STRING:   A1SL44
- GeneID:   4596475
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3027
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VICEVKR
- PhylomeDB:   A1SL44
- BioCyc:   NSP35761:NOCA_3027-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27551; Mature: 27420

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLDDIVAGVRLDLAERESATSLADLRAALADVDPPRDPMPHFRAAGSSVIAEVKRRSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SKGDLATIPDPAELARSYAAGGAAAISVLTEQRRFGGSLADLRAVRAAVDTPILRKDFIV
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
SSYQVVEARAAGADLVLLIVAALDDDDLRRLHDEARELGLTALVEVHDEPETERAVALGA
HHHHHHHHHHCCCCEEHHHHHHCCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHH
ELVGVNARNLKTLAIHDDTFGRLAPLVPDDRVKVAESGIFGPDDVARFVREGARAVLVGE
HHCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEHH
ALVKDGDPEGAVRRMTGVES
HHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SVLDDIVAGVRLDLAERESATSLADLRAALADVDPPRDPMPHFRAAGSSVIAEVKRRSP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SKGDLATIPDPAELARSYAAGGAAAISVLTEQRRFGGSLADLRAVRAAVDTPILRKDFIV
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
SSYQVVEARAAGADLVLLIVAALDDDDLRRLHDEARELGLTALVEVHDEPETERAVALGA
HHHHHHHHHHCCCCEEHHHHHHCCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHH
ELVGVNARNLKTLAIHDDTFGRLAPLVPDDRVKVAESGIFGPDDVARFVREGARAVLVGE
HHCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEHH
ALVKDGDPEGAVRRMTGVES
HHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA