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The map label for this gene is polA [H]

Identifier: 119717230

GI number: 119717230

Start: 3202076

End: 3204745

Strand: Reverse

Name: polA [H]

Synonym: Noca_3006

Alternate gene names: 119717230

Gene position: 3204745-3202076 (Counterclockwise)

Preceding gene: 119717232

Following gene: 119717229

Centisome position: 64.28

GC content: 70.6

Gene sequence:

>2670_bases
GTGCCCCGCCTCCTGCTCCTCGACGGCCACTCGCTCGCGTATCGCGCGTTCTTCGCGCTGCCGGTGGAGAACTTCTCGAC
CACGACCGGCCAGCACACCAACGCGGTCTACGGCTTCACCTCGATGCTGATCAACGTGCTGCGCGACGAGCAGCCGACCC
ACGTGGGCGTGGCGTTCGACGTGTCCCGGCAGACCTTCCGGCTGGAGGAGTACGCCGACTACAAGGCCAAGCGCAACAAG
ACGCCGACCGAGTTCAGCAGCCAGCTGCCGCTGATCGAGGAGGTCCTCAACGCGCTGCGGATCCCGTTCCTGAAGAAGGA
CGGCTACGAGGCCGACGACATCATCGCCACGCTGGTCACCCGCGCGCTCGAGGACCCCGAGATGGAGGTGCTGATCCTCA
CCGGCGACCGTGACTCGCTCCAGCTGGTCACCGACCGCTCGACCGTGCTCTACCCGATGCGGGGGGTCTCCGACCTGGCC
CGGATGACGCCGGCAGCGGTCGAGGCCAAGTACGGCGTCCCGCCGGCGCGCTACCCCGAGCTCGCGGCGATCGTGGGGGA
GACCTCCGACAACCTCCCGGGTGTGCCGGGGGTCGGCCAGGGCTACGCGGCGAAGTGGATCAACCAGTTCGACGGCCTCG
ACAACGTGATCGCCCGCGCCGACGAGATCACCGGCAAGAAGGGCGAGGCGCTGCGGGCCCACCTCGGCGACGTGATCCGC
AACCGCCACCTCAACGCCCTCGTGTGCGACCTCGAGCTCGACCGGACCCCCGAGCAGCTCGCGGTGCAGCCGTGGGACCG
CCACGAGGTGCACACGCTCTTCGACGGCCTCGAGTTCCGGGTGCTGCGCGACCGCCTCTTCGAGACGCTCACCTCGGAGG
AGGAGATCGACGACTCCGGCTTCGACGTCGCGATGAGCGTGCTGGGCGCCGGCGCGCTGGCGGCGTGGCTCGAGCAGCAC
ACCGCCTCCGGCGAGCGGGTCGGCCTGCACGTCGCGGGGCACTGGAGCGCGGGCACCGGTGACGTGACGTCGTTGGCGCT
GGCGACCACCGACGGCCTCGCGGCCTGGGTCGCCGCCGACCAGCTCGACGTGGCCGACCAGACCGCGCTCGCCGGGTGGC
TGGCCGATCCCAAGCGGCCCAAGGTGCTCCACGACGCGAAGGGGCCGATGCTCGCCCTGGCCGCCTGGGGCCTGCCGCTG
GCCGGCCTGGACCGGGACACCGCGCTCTCGGCGTACCTCGCCCGGCCCGACCAGCGCTCCTACGACCTGGCGGACCTGAC
CGTGCGCTACCTCAAGCGTGAGCTCAAGCAGGGTGGAGCCGACGACGGCCAGCTCAGCCTCGACGGCCTGGACGACCGGA
ACGCCGGCGAGATCGAGATGCTGCACGCCCGGGCCGTCCTCGACCTGGCCGCAGCGCTGGACGACGAGCTCGAGGAGCGC
GGCGGCACCCGCCTGCTCAACGACATCGAGCTGCCGCTGGTCGACCTGCTCGCCAAGATGGAGCAGACCGGCATCGCCGT
CGACACCGACCACCTCGAGGCGCTGGAGAGCCACTTCGCCGCCGAGGTGCGCGACGCGGCCGAGCAGGCGTTCGGCGTGA
TCGGCAAGGAGATCAACCTCGGCTCGCCCAAGCAGCTGCAGGCCGTGCTGTTCGACGAGCTCGGGATGCCGAAGACCAAG
CGCACCAAGACCGGCTACACGACCGACGCGGACGCGCTCCAGGCGCTGTACGTCAAGACCGAGCACCCGTTCCTGCTGCA
CCTGCTGCGCCACCGCGACGTGTCCCGGCTGCGCCAGACGATCGAGGGCCTGCTCAAGACCGTCGCGGGCGACGGCCGCA
TCCACACGACGTTCAACCAGACGATCGCCGCGACCGGCCGCCTGTCCAGCACCGAACCCAACCTCCAGAACATCCCGATC
CGCACCGAGGAGGGCCGCCGGATCCGCGAGGGCTTCGTGGTCGGTCCGGGGTACGAGTCGTTGATGACCGCCGACTACAG
CCAGATCGAGATGCGGATCATGGCGCACCTGTCCGAGGACGACCTGCTGATCGAGGCGTTCAAGTCCGGTCGCGACTTCC
ACTCGATCACCGCCGCCCGGGTCTTCGACGTGCCGGCCGACGACGTCACGGTCGAGATGCGGGCCAAGATCAAGGCGATG
AACTACGGCCTGGCCTACGGCCTGTCCGCGTTCGGCCTGGGCCAACAGCTCGGCATCGAGCCGAGCGAGGCCCGCGGGCT
GATGGACGAGTACTTCCAGACCTTCGGCGGGATCCGCGACTACCTCGGCGGCGTCGTCGAGGAGGCCCGCAAGGCCGGGT
TCACCGAGACCATCTGGGGCCGTCGCCGCTACCTGCCCGACCTCACGAGCGACAACCGCCAGCGCCGCGAGATGGCCGAG
CGGATGGCGCTGAACGCGCCGATCCAGGGCTCGGCCGCCGACCTGATCAAGATCGCGATGCTCAACGTCGACCGGGCGAT
CGCCGCCGCCGGGCTGGCCTCGCGGATGCTGCTCCAGGTGCACGACGAGCTCGTGTTCGAGGTGGCGCCGGGGGAGCAGG
AGCCGCTCGAGGTCCTGGTCCGCGAGCAGATGGGCGCCGCCGCGGACCTCGCCGTACCCCTCGACGTGAGCGTGGGCTTC
GGCCGCAGCTGGCACGAGGCGGCCCACTGA

Upstream 100 bases:

>100_bases
CGATGTCCATCTCGGGGCCCGTCTCGGGGCTCTGGTCAGGGCTCTGGCCGTCGCTCATGGGCCCATTCTGGCTGTCGGTC
CGCGCCGCTAGAGTCGCAGG

Downstream 100 bases:

>100_bases
TGAAGAGGATCGGGTTCCTCTCCTTCGGGCACTGGACGCCGTCCCCGCAGTCCCAGGTGCGCACCGGCGCCGACGCGCTG
CTGCAGTCGATCGACCTGGC

Product: DNA polymerase I

Products: NA

Alternate protein names: POL I [H]

Number of amino acids: Translated: 889; Mature: 888

Protein sequence:

>889_residues
MPRLLLLDGHSLAYRAFFALPVENFSTTTGQHTNAVYGFTSMLINVLRDEQPTHVGVAFDVSRQTFRLEEYADYKAKRNK
TPTEFSSQLPLIEEVLNALRIPFLKKDGYEADDIIATLVTRALEDPEMEVLILTGDRDSLQLVTDRSTVLYPMRGVSDLA
RMTPAAVEAKYGVPPARYPELAAIVGETSDNLPGVPGVGQGYAAKWINQFDGLDNVIARADEITGKKGEALRAHLGDVIR
NRHLNALVCDLELDRTPEQLAVQPWDRHEVHTLFDGLEFRVLRDRLFETLTSEEEIDDSGFDVAMSVLGAGALAAWLEQH
TASGERVGLHVAGHWSAGTGDVTSLALATTDGLAAWVAADQLDVADQTALAGWLADPKRPKVLHDAKGPMLALAAWGLPL
AGLDRDTALSAYLARPDQRSYDLADLTVRYLKRELKQGGADDGQLSLDGLDDRNAGEIEMLHARAVLDLAAALDDELEER
GGTRLLNDIELPLVDLLAKMEQTGIAVDTDHLEALESHFAAEVRDAAEQAFGVIGKEINLGSPKQLQAVLFDELGMPKTK
RTKTGYTTDADALQALYVKTEHPFLLHLLRHRDVSRLRQTIEGLLKTVAGDGRIHTTFNQTIAATGRLSSTEPNLQNIPI
RTEEGRRIREGFVVGPGYESLMTADYSQIEMRIMAHLSEDDLLIEAFKSGRDFHSITAARVFDVPADDVTVEMRAKIKAM
NYGLAYGLSAFGLGQQLGIEPSEARGLMDEYFQTFGGIRDYLGGVVEEARKAGFTETIWGRRRYLPDLTSDNRQRREMAE
RMALNAPIQGSAADLIKIAMLNVDRAIAAAGLASRMLLQVHDELVFEVAPGEQEPLEVLVREQMGAAADLAVPLDVSVGF
GRSWHEAAH

Sequences:

>Translated_889_residues
MPRLLLLDGHSLAYRAFFALPVENFSTTTGQHTNAVYGFTSMLINVLRDEQPTHVGVAFDVSRQTFRLEEYADYKAKRNK
TPTEFSSQLPLIEEVLNALRIPFLKKDGYEADDIIATLVTRALEDPEMEVLILTGDRDSLQLVTDRSTVLYPMRGVSDLA
RMTPAAVEAKYGVPPARYPELAAIVGETSDNLPGVPGVGQGYAAKWINQFDGLDNVIARADEITGKKGEALRAHLGDVIR
NRHLNALVCDLELDRTPEQLAVQPWDRHEVHTLFDGLEFRVLRDRLFETLTSEEEIDDSGFDVAMSVLGAGALAAWLEQH
TASGERVGLHVAGHWSAGTGDVTSLALATTDGLAAWVAADQLDVADQTALAGWLADPKRPKVLHDAKGPMLALAAWGLPL
AGLDRDTALSAYLARPDQRSYDLADLTVRYLKRELKQGGADDGQLSLDGLDDRNAGEIEMLHARAVLDLAAALDDELEER
GGTRLLNDIELPLVDLLAKMEQTGIAVDTDHLEALESHFAAEVRDAAEQAFGVIGKEINLGSPKQLQAVLFDELGMPKTK
RTKTGYTTDADALQALYVKTEHPFLLHLLRHRDVSRLRQTIEGLLKTVAGDGRIHTTFNQTIAATGRLSSTEPNLQNIPI
RTEEGRRIREGFVVGPGYESLMTADYSQIEMRIMAHLSEDDLLIEAFKSGRDFHSITAARVFDVPADDVTVEMRAKIKAM
NYGLAYGLSAFGLGQQLGIEPSEARGLMDEYFQTFGGIRDYLGGVVEEARKAGFTETIWGRRRYLPDLTSDNRQRREMAE
RMALNAPIQGSAADLIKIAMLNVDRAIAAAGLASRMLLQVHDELVFEVAPGEQEPLEVLVREQMGAAADLAVPLDVSVGF
GRSWHEAAH
>Mature_888_residues
PRLLLLDGHSLAYRAFFALPVENFSTTTGQHTNAVYGFTSMLINVLRDEQPTHVGVAFDVSRQTFRLEEYADYKAKRNKT
PTEFSSQLPLIEEVLNALRIPFLKKDGYEADDIIATLVTRALEDPEMEVLILTGDRDSLQLVTDRSTVLYPMRGVSDLAR
MTPAAVEAKYGVPPARYPELAAIVGETSDNLPGVPGVGQGYAAKWINQFDGLDNVIARADEITGKKGEALRAHLGDVIRN
RHLNALVCDLELDRTPEQLAVQPWDRHEVHTLFDGLEFRVLRDRLFETLTSEEEIDDSGFDVAMSVLGAGALAAWLEQHT
ASGERVGLHVAGHWSAGTGDVTSLALATTDGLAAWVAADQLDVADQTALAGWLADPKRPKVLHDAKGPMLALAAWGLPLA
GLDRDTALSAYLARPDQRSYDLADLTVRYLKRELKQGGADDGQLSLDGLDDRNAGEIEMLHARAVLDLAAALDDELEERG
GTRLLNDIELPLVDLLAKMEQTGIAVDTDHLEALESHFAAEVRDAAEQAFGVIGKEINLGSPKQLQAVLFDELGMPKTKR
TKTGYTTDADALQALYVKTEHPFLLHLLRHRDVSRLRQTIEGLLKTVAGDGRIHTTFNQTIAATGRLSSTEPNLQNIPIR
TEEGRRIREGFVVGPGYESLMTADYSQIEMRIMAHLSEDDLLIEAFKSGRDFHSITAARVFDVPADDVTVEMRAKIKAMN
YGLAYGLSAFGLGQQLGIEPSEARGLMDEYFQTFGGIRDYLGGVVEEARKAGFTETIWGRRRYLPDLTSDNRQRREMAER
MALNAPIQGSAADLIKIAMLNVDRAIAAAGLASRMLLQVHDELVFEVAPGEQEPLEVLVREQMGAAADLAVPLDVSVGFG
RSWHEAAH

Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]

COG id: COG0749

COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 5'-3' exonuclease domain [H]

Homologues:

Organism=Homo sapiens, GI112420958, Length=515, Percent_Identity=31.6504854368932, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI139394648, Length=619, Percent_Identity=26.9789983844911, Blast_Score=202, Evalue=1e-51,
Organism=Escherichia coli, GI1790294, Length=929, Percent_Identity=35.5220667384284, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI226510970, Length=235, Percent_Identity=24.6808510638298, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86563272, Length=391, Percent_Identity=29.156010230179, Blast_Score=152, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17933644, Length=418, Percent_Identity=34.2105263157895, Blast_Score=224, Evalue=3e-58,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR020046
- InterPro:   IPR020045
- InterPro:   IPR002421
- InterPro:   IPR020047
- InterPro:   IPR019760
- InterPro:   IPR001098
- InterPro:   IPR018320
- InterPro:   IPR002298
- InterPro:   IPR008918
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 97606; Mature: 97474

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLLLLDGHSLAYRAFFALPVENFSTTTGQHTNAVYGFTSMLINVLRDEQPTHVGVAFD
CCCEEEECCCCCEEHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
VSRQTFRLEEYADYKAKRNKTPTEFSSQLPLIEEVLNALRIPFLKKDGYEADDIIATLVT
CCCHHEEHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RALEDPEMEVLILTGDRDSLQLVTDRSTVLYPMRGVSDLARMTPAAVEAKYGVPPARYPE
HHCCCCCEEEEEEECCCCCEEEEECCCEEEEECCCHHHHHHCCHHHHHHCCCCCCCCCCH
LAAIVGETSDNLPGVPGVGQGYAAKWINQFDGLDNVIARADEITGKKGEALRAHLGDVIR
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NRHLNALVCDLELDRTPEQLAVQPWDRHEVHTLFDGLEFRVLRDRLFETLTSEEEIDDSG
CCCCCEEEEEEECCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCC
FDVAMSVLGAGALAAWLEQHTASGERVGLHVAGHWSAGTGDVTSLALATTDGLAAWVAAD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHEEEEEECCCHHHHHHHC
QLDVADQTALAGWLADPKRPKVLHDAKGPMLALAAWGLPLAGLDRDTALSAYLARPDQRS
CCCHHHHHHHHHHCCCCCCCCCEECCCCCEEEEHHCCCCCCCCCCHHHHHHHHCCCCCCC
YDLADLTVRYLKRELKQGGADDGQLSLDGLDDRNAGEIEMLHARAVLDLAAALDDELEER
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHC
GGTRLLNDIELPLVDLLAKMEQTGIAVDTDHLEALESHFAAEVRDAAEQAFGVIGKEINL
CCCEEHHHCCCCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSPKQLQAVLFDELGMPKTKRTKTGYTTDADALQALYVKTEHPFLLHLLRHRDVSRLRQT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHCCHHHHHHH
IEGLLKTVAGDGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTEEGRRIREGFVVGPGYES
HHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCEECCCCCEECCCCEECCCHHH
LMTADYSQIEMRIMAHLSEDDLLIEAFKSGRDFHSITAARVFDVPADDVTVEMRAKIKAM
HHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHEEECCCCCEEEHHHHHHHHH
NYGLAYGLSAFGLGQQLGIEPSEARGLMDEYFQTFGGIRDYLGGVVEEARKAGFTETIWG
HCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
RRRYLPDLTSDNRQRREMAERMALNAPIQGSAADLIKIAMLNVDRAIAAAGLASRMLLQV
HHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDELVFEVAPGEQEPLEVLVREQMGAAADLAVPLDVSVGFGRSWHEAAH
HHHHEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHCC
>Mature Secondary Structure 
PRLLLLDGHSLAYRAFFALPVENFSTTTGQHTNAVYGFTSMLINVLRDEQPTHVGVAFD
CCEEEECCCCCEEHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
VSRQTFRLEEYADYKAKRNKTPTEFSSQLPLIEEVLNALRIPFLKKDGYEADDIIATLVT
CCCHHEEHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RALEDPEMEVLILTGDRDSLQLVTDRSTVLYPMRGVSDLARMTPAAVEAKYGVPPARYPE
HHCCCCCEEEEEEECCCCCEEEEECCCEEEEECCCHHHHHHCCHHHHHHCCCCCCCCCCH
LAAIVGETSDNLPGVPGVGQGYAAKWINQFDGLDNVIARADEITGKKGEALRAHLGDVIR
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NRHLNALVCDLELDRTPEQLAVQPWDRHEVHTLFDGLEFRVLRDRLFETLTSEEEIDDSG
CCCCCEEEEEEECCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCC
FDVAMSVLGAGALAAWLEQHTASGERVGLHVAGHWSAGTGDVTSLALATTDGLAAWVAAD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHEEEEEECCCHHHHHHHC
QLDVADQTALAGWLADPKRPKVLHDAKGPMLALAAWGLPLAGLDRDTALSAYLARPDQRS
CCCHHHHHHHHHHCCCCCCCCCEECCCCCEEEEHHCCCCCCCCCCHHHHHHHHCCCCCCC
YDLADLTVRYLKRELKQGGADDGQLSLDGLDDRNAGEIEMLHARAVLDLAAALDDELEER
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHC
GGTRLLNDIELPLVDLLAKMEQTGIAVDTDHLEALESHFAAEVRDAAEQAFGVIGKEINL
CCCEEHHHCCCCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSPKQLQAVLFDELGMPKTKRTKTGYTTDADALQALYVKTEHPFLLHLLRHRDVSRLRQT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHCCHHHHHHH
IEGLLKTVAGDGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTEEGRRIREGFVVGPGYES
HHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCEECCCCCEECCCCEECCCHHH
LMTADYSQIEMRIMAHLSEDDLLIEAFKSGRDFHSITAARVFDVPADDVTVEMRAKIKAM
HHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHEEECCCCCEEEHHHHHHHHH
NYGLAYGLSAFGLGQQLGIEPSEARGLMDEYFQTFGGIRDYLGGVVEEARKAGFTETIWG
HCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
RRRYLPDLTSDNRQRREMAERMALNAPIQGSAADLIKIAMLNVDRAIAAAGLASRMLLQV
HHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDELVFEVAPGEQEPLEVLVREQMGAAADLAVPLDVSVGFGRSWHEAAH
HHHHEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]