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The map label for this gene is 119715232

Identifier: 119715232

GI number: 119715232

Start: 1038869

End: 1039771

Strand: Reverse

Name: 119715232

Synonym: Noca_0989

Alternate gene names: NA

Gene position: 1039771-1038869 (Counterclockwise)

Preceding gene: 119715233

Following gene: 119715230

Centisome position: 20.85

GC content: 75.08

Gene sequence:

>903_bases
ATGACCACCACCCACGCGCCCGCGGGTTCCGTCGTCGTCGGCGTCGACGGCTCCCCCTCCGCGACCCACGCCGTCAGCTG
GGCGGCCGAGCAGGCCGCCGTCGAGGGCCGGCCACTGGTGCTGGTGCACGTCGGTCCGACGCCGGCCCCGGCCGGTACCG
GCTGGATGGAGGCGGCCGGCGTCGACCACCATCGGCTGGCCGCGCTGCTCAAGGACGACGCCCGGGTGCTGTTGGAGCAG
GCCGCCGCCCCGGTCCGTGCCGAGCACCCCGACGTGGAGATCCACCACCTGGTGCGGCTCGGCGACGCACGGCAGATGCT
GCTCGAGGCGTCCGCGGAGGCGCGGCTCCTCGTGGTCGGCACCCGCGGCCTGGGTCCGGTGCGGCACCTGCTCCTCGGCT
CGGTCAGCAGCGCGCTCGTCAAGCACGCGACCTGCCCGGTGGTCGTAGTGCGTCCCGACCCGGAGCACGCGGACGGTCCC
GCCCGGGTGCTGGCCGGGGTCGCCGGCGAACCCGGCGACGCCGCCGTCCTCGACCTGGCCTTCGACCTCGCCGAGACGCG
CAAGCTGCCGCTGCGGGTCTTCCACTGCTTCTGGGACGCGGTGAAGATCGCCGAGGGCGCCCGCGACGTCGCCCCCGGTG
AGCCCGGCCTGGACGACGAGTGGCTGGTGCTCGACCGCGCGGTCCGCCCACACACCGAGGCGCACCCCAGCGTCGAGGTC
CAGCTCCAGCTGACCCGCGGCATGGTCGACGAGCGACTGATCCGCGCCTCCCACGACGCGGCACTGGTCGTCGTCGGCCA
CCGGCGCAAGCCGTTCCTCAACGAGCTCGTCTACGGCTCGGTCGCGCCGGTCGTCGTCGAGCGGTCCGCCTGCACGGTCG
CGATCGTCCCGCTCGGGAGCTGA

Upstream 100 bases:

>100_bases
GGGCGAACGAGCCCCGACCGGCGCCGACCGGGCCGTTGGTCCCCGGGCCCCGAGCCCTCCGGCCGTGGCCGGTCCCTGAC
GGCTGGGCGATGGTGGAGGC

Downstream 100 bases:

>100_bases
GCGCCGGCGGGTCGATCCGGCTCGGTCCCGCCCGGCCAGCGGTGCCCAGGCAACCCAACCCACCCGCCGAACGGTTGCTG
GCACACCGCCGACCCGGCGA

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTTTHAPAGSVVVGVDGSPSATHAVSWAAEQAAVEGRPLVLVHVGPTPAPAGTGWMEAAGVDHHRLAALLKDDARVLLEQ
AAAPVRAEHPDVEIHHLVRLGDARQMLLEASAEARLLVVGTRGLGPVRHLLLGSVSSALVKHATCPVVVVRPDPEHADGP
ARVLAGVAGEPGDAAVLDLAFDLAETRKLPLRVFHCFWDAVKIAEGARDVAPGEPGLDDEWLVLDRAVRPHTEAHPSVEV
QLQLTRGMVDERLIRASHDAALVVVGHRRKPFLNELVYGSVAPVVVERSACTVAIVPLGS

Sequences:

>Translated_300_residues
MTTTHAPAGSVVVGVDGSPSATHAVSWAAEQAAVEGRPLVLVHVGPTPAPAGTGWMEAAGVDHHRLAALLKDDARVLLEQ
AAAPVRAEHPDVEIHHLVRLGDARQMLLEASAEARLLVVGTRGLGPVRHLLLGSVSSALVKHATCPVVVVRPDPEHADGP
ARVLAGVAGEPGDAAVLDLAFDLAETRKLPLRVFHCFWDAVKIAEGARDVAPGEPGLDDEWLVLDRAVRPHTEAHPSVEV
QLQLTRGMVDERLIRASHDAALVVVGHRRKPFLNELVYGSVAPVVVERSACTVAIVPLGS
>Mature_299_residues
TTTHAPAGSVVVGVDGSPSATHAVSWAAEQAAVEGRPLVLVHVGPTPAPAGTGWMEAAGVDHHRLAALLKDDARVLLEQA
AAPVRAEHPDVEIHHLVRLGDARQMLLEASAEARLLVVGTRGLGPVRHLLLGSVSSALVKHATCPVVVVRPDPEHADGPA
RVLAGVAGEPGDAAVLDLAFDLAETRKLPLRVFHCFWDAVKIAEGARDVAPGEPGLDDEWLVLDRAVRPHTEAHPSVEVQ
LQLTRGMVDERLIRASHDAALVVVGHRRKPFLNELVYGSVAPVVVERSACTVAIVPLGS

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 31612; Mature: 31480

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTHAPAGSVVVGVDGSPSATHAVSWAAEQAAVEGRPLVLVHVGPTPAPAGTGWMEAAG
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCC
VDHHRLAALLKDDARVLLEQAAAPVRAEHPDVEIHHLVRLGDARQMLLEASAEARLLVVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCHHHHHHHHCCCCEEEEEEE
TRGLGPVRHLLLGSVSSALVKHATCPVVVVRPDPEHADGPARVLAGVAGEPGDAAVLDLA
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEHHH
FDLAETRKLPLRVFHCFWDAVKIAEGARDVAPGEPGLDDEWLVLDRAVRPHTEAHPSVEV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEE
QLQLTRGMVDERLIRASHDAALVVVGHRRKPFLNELVYGSVAPVVVERSACTVAIVPLGS
EEEEHHCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEECCCCEEEEEECCC
>Mature Secondary Structure 
TTTHAPAGSVVVGVDGSPSATHAVSWAAEQAAVEGRPLVLVHVGPTPAPAGTGWMEAAG
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCC
VDHHRLAALLKDDARVLLEQAAAPVRAEHPDVEIHHLVRLGDARQMLLEASAEARLLVVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCHHHHHHHHCCCCEEEEEEE
TRGLGPVRHLLLGSVSSALVKHATCPVVVVRPDPEHADGPARVLAGVAGEPGDAAVLDLA
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEHHH
FDLAETRKLPLRVFHCFWDAVKIAEGARDVAPGEPGLDDEWLVLDRAVRPHTEAHPSVEV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEE
QLQLTRGMVDERLIRASHDAALVVVGHRRKPFLNELVYGSVAPVVVERSACTVAIVPLGS
EEEEHHCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]