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The map label for this gene is pth [H]

Identifier: 119715157

GI number: 119715157

Start: 955904

End: 956557

Strand: Direct

Name: pth [H]

Synonym: Noca_0912

Alternate gene names: 119715157

Gene position: 955904-956557 (Clockwise)

Preceding gene: 119715156

Following gene: 119715158

Centisome position: 19.17

GC content: 72.48

Gene sequence:

>654_bases
GTGACCCTCCGTCACCTGTTCCGCCGGAACGTCCGTGGGAAGGGCCGGGATCGCGTGGCCGACTCCGCTGCACCCGTGTG
GCTGGTGGTCGGGCTGGGCAATCCCGGCCCGACCTACGCCGGGCACCGTCACAACGTGGGCTACCTCGTCGCCGACGAGC
TCGCCTCGCGGCTCGGCGCGCCGTTCCGCGCGCACAAGTCCGGCCGGGCCGAGGTCGTCGAGGGGCGGCTGGGCGTGCCC
GGGCAGCCCGGCCCCCGGGTCGTGCTGATGCGTGCCCGGTGCTACATGAACGAGACCGGCGGCCCGGTGAAGCAGCTCGC
GGGGTTCTACAAGGTCCCGCCCGAGCGGATCATCGCCGTGCACGACGAGCTCGACATCGCGTTCGACACGATGCGGGTCA
AGCTCGGCGGCGGCGACAACGGCCACAACGGGCTGCGCTCGATGCGCAGCTCGCTCGGCACCGGCGACTTCTACCGGGTC
CGGGTCGGCATCGGCCGTCCACCGGGCCGGCAGGACCCGGCCGACTTCGTGCTCTCCAACTACTCCTCGTCCGAGCGCAA
GGTGCTGCCGTTCCAGGTCGACCGGGCCGCGGACGCCGTCGAGGCGCTGGTCACCGAGGGCCTCGAGCGCACCCAGCAGC
GCTTCAACTCCTGA

Upstream 100 bases:

>100_bases
AGGCCGAGGCCGAGGCCGGCATCGAGCGCGACGAGGTCGAGAAGGACGTCGACGAGGTCGGCGCCGCGGAGACCGAGAGC
ACCGAGGCCGCGACCGAGGA

Downstream 100 bases:

>100_bases
TCGCCAACGCCCGATCGATAGGGTTCCCCGCATGAGCTTCGACCCCGGCGCCCCGCCCGCCGCCGCCGAGACCGACGACC
ACTCACTCGCCGCCTGGCTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTLRHLFRRNVRGKGRDRVADSAAPVWLVVGLGNPGPTYAGHRHNVGYLVADELASRLGAPFRAHKSGRAEVVEGRLGVP
GQPGPRVVLMRARCYMNETGGPVKQLAGFYKVPPERIIAVHDELDIAFDTMRVKLGGGDNGHNGLRSMRSSLGTGDFYRV
RVGIGRPPGRQDPADFVLSNYSSSERKVLPFQVDRAADAVEALVTEGLERTQQRFNS

Sequences:

>Translated_217_residues
MTLRHLFRRNVRGKGRDRVADSAAPVWLVVGLGNPGPTYAGHRHNVGYLVADELASRLGAPFRAHKSGRAEVVEGRLGVP
GQPGPRVVLMRARCYMNETGGPVKQLAGFYKVPPERIIAVHDELDIAFDTMRVKLGGGDNGHNGLRSMRSSLGTGDFYRV
RVGIGRPPGRQDPADFVLSNYSSSERKVLPFQVDRAADAVEALVTEGLERTQQRFNS
>Mature_216_residues
TLRHLFRRNVRGKGRDRVADSAAPVWLVVGLGNPGPTYAGHRHNVGYLVADELASRLGAPFRAHKSGRAEVVEGRLGVPG
QPGPRVVLMRARCYMNETGGPVKQLAGFYKVPPERIIAVHDELDIAFDTMRVKLGGGDNGHNGLRSMRSSLGTGDFYRVR
VGIGRPPGRQDPADFVLSNYSSSERKVLPFQVDRAADAVEALVTEGLERTQQRFNS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=39.0804597701149, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=38.2198952879581, Blast_Score=110, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=32.2404371584699, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 23741; Mature: 23610

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRHLFRRNVRGKGRDRVADSAAPVWLVVGLGNPGPTYAGHRHNVGYLVADELASRLGA
CCHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCC
PFRAHKSGRAEVVEGRLGVPGQPGPRVVLMRARCYMNETGGPVKQLAGFYKVPPERIIAV
CCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHHHHHCCCHHHEEEE
HDELDIAFDTMRVKLGGGDNGHNGLRSMRSSLGTGDFYRVRVGIGRPPGRQDPADFVLSN
CCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHC
YSSSERKVLPFQVDRAADAVEALVTEGLERTQQRFNS
CCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLRHLFRRNVRGKGRDRVADSAAPVWLVVGLGNPGPTYAGHRHNVGYLVADELASRLGA
CHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCC
PFRAHKSGRAEVVEGRLGVPGQPGPRVVLMRARCYMNETGGPVKQLAGFYKVPPERIIAV
CCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHHHHHCCCHHHEEEE
HDELDIAFDTMRVKLGGGDNGHNGLRSMRSSLGTGDFYRVRVGIGRPPGRQDPADFVLSN
CCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHC
YSSSERKVLPFQVDRAADAVEALVTEGLERTQQRFNS
CCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]