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The map label for this gene is prs [H]

Identifier: 119715154

GI number: 119715154

Start: 951523

End: 952566

Strand: Direct

Name: prs [H]

Synonym: Noca_0909

Alternate gene names: 119715154

Gene position: 951523-952566 (Clockwise)

Preceding gene: 119715153

Following gene: 119715156

Centisome position: 19.08

GC content: 68.3

Gene sequence:

>1044_bases
GTGAACAGGACGTGGCAGAATCCTGACCAGCCCCCTCCGGCGACCCCTTCCACGACCGAGGAGCAGCGCACCGTGACCGG
TATGAAGAGGACCACCGAGAAGAACCTCATGGTCTTCAGTGGCCGGGCCCACCCTGTGCTCGCGGAGGAGGTCGCGACCC
TGCTGGGCACCCCGCTGGTGCCCCAGTCGGCGTACGAGTTCGCGAACTCCGAGATCTACGTGCGCTACGAGGAGTCCGTG
CGCGGCTGTGACGCGTTCGTGCTGCAGAGCCACACCGCTCCGGTCAACGAGTGGATCATGGAGCACCTGATCATGGTCGA
CGCGCTCAAGCGCGCCTCGGCCAAGCGGATCACCGTGGTGATGCCGTTCTACGGCTACGCCCGCCAGGACAAGAAGCACA
AGGGCCGCGAGCCGATCTCGGCGCGGCTGATGGCCGACCTGTTCAAGACCGCCGGCGCCAACCGGCTGATCACGGTCGAC
CTGCACGCCGACCAGATCCAGGGCTTCTTCGACGGCCCGGTCGACCACCTGATGGCGCTGCCGATCCTCGCGGACTACGT
CCGGGACAAGTACGGTTCCCAGCCGCTCGCGGTGGTGTCGCCGGACGCCGGCCGGATCAAGGTCGCCGAGCGCTGGTCGG
CGCGCCTCGGGGGCGCGCCGCTGGCGTTCATCCACAAGACCCGGCGCACCGACCGGCCGAACGAGAGCGTCGCCAACCGC
GTCGTCGGCGACGTGTCGGGGCGGATGTGCGTGCTGGTCGACGACATGATCGACACCGGTGGCACCATCGTGAAGGCGGC
CGAGGCGCTGATGGCCGACGGCGCCGCGGGCGTGATCATCGCCGCGACCCACGCGATCCTCTCCGACCCGGCCGTGGACC
GGCTCAAGAACTGTTCGGCCGTCGAGGTCGTGGTCACCAACACGCTGCCGCTCGCACCCGAGTGCGAGTTCGACAAGCTC
ACCACGCTCTCGATCGCGCCACTGATCTCCCGCGCGATCCGCGAGGTCTTCGAGGACGGCTCCGTCACCTCGATGTTCGA
GTAG

Upstream 100 bases:

>100_bases
GGCGGTCCGCAGCGCAACCTCGAGGGCTGGACCCTGGCCAAGCGCGCCGGTACCGCGCAGGCGCAGGCTGCCGCGGACGC
GCTGGGCACGGGTCGGGACG

Downstream 100 bases:

>100_bases
CCGGCGACCGCTATCGCAGGTCGTCGCGCCAGTCCGCCCACTGCCGGCGCAGCACCGTCGGCAGGTCGCCGGCGAGCGCC
CGGTCGAGACCGGCCACCTG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNRTWQNPDQPPPATPSTTEEQRTVTGMKRTTEKNLMVFSGRAHPVLAEEVATLLGTPLVPQSAYEFANSEIYVRYEESV
RGCDAFVLQSHTAPVNEWIMEHLIMVDALKRASAKRITVVMPFYGYARQDKKHKGREPISARLMADLFKTAGANRLITVD
LHADQIQGFFDGPVDHLMALPILADYVRDKYGSQPLAVVSPDAGRIKVAERWSARLGGAPLAFIHKTRRTDRPNESVANR
VVGDVSGRMCVLVDDMIDTGGTIVKAAEALMADGAAGVIIAATHAILSDPAVDRLKNCSAVEVVVTNTLPLAPECEFDKL
TTLSIAPLISRAIREVFEDGSVTSMFE

Sequences:

>Translated_347_residues
MNRTWQNPDQPPPATPSTTEEQRTVTGMKRTTEKNLMVFSGRAHPVLAEEVATLLGTPLVPQSAYEFANSEIYVRYEESV
RGCDAFVLQSHTAPVNEWIMEHLIMVDALKRASAKRITVVMPFYGYARQDKKHKGREPISARLMADLFKTAGANRLITVD
LHADQIQGFFDGPVDHLMALPILADYVRDKYGSQPLAVVSPDAGRIKVAERWSARLGGAPLAFIHKTRRTDRPNESVANR
VVGDVSGRMCVLVDDMIDTGGTIVKAAEALMADGAAGVIIAATHAILSDPAVDRLKNCSAVEVVVTNTLPLAPECEFDKL
TTLSIAPLISRAIREVFEDGSVTSMFE
>Mature_347_residues
MNRTWQNPDQPPPATPSTTEEQRTVTGMKRTTEKNLMVFSGRAHPVLAEEVATLLGTPLVPQSAYEFANSEIYVRYEESV
RGCDAFVLQSHTAPVNEWIMEHLIMVDALKRASAKRITVVMPFYGYARQDKKHKGREPISARLMADLFKTAGANRLITVD
LHADQIQGFFDGPVDHLMALPILADYVRDKYGSQPLAVVSPDAGRIKVAERWSARLGGAPLAFIHKTRRTDRPNESVANR
VVGDVSGRMCVLVDDMIDTGGTIVKAAEALMADGAAGVIIAATHAILSDPAVDRLKNCSAVEVVVTNTLPLAPECEFDKL
TTLSIAPLISRAIREVFEDGSVTSMFE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=42.9936305732484, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=42.9936305732484, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=42.5867507886435, Blast_Score=234, Evalue=6e-62,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=42.0382165605096, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4506133, Length=350, Percent_Identity=34.8571428571429, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI194018537, Length=332, Percent_Identity=35.8433734939759, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=31.7241379310345, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=31.7241379310345, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=31.7241379310345, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=31.7241379310345, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=44.7619047619048, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=42.0382165605096, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=42.0382165605096, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=42.0382165605096, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=42.1221864951768, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=32.8402366863905, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=41.3249211356467, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=338, Percent_Identity=39.6449704142012, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321776, Length=306, Percent_Identity=41.5032679738562, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=38.265306122449, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324511, Length=269, Percent_Identity=28.2527881040892, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21355239, Length=342, Percent_Identity=40.3508771929825, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI45551540, Length=365, Percent_Identity=37.8082191780822, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI281362873, Length=368, Percent_Identity=33.4239130434783, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651454, Length=368, Percent_Identity=33.4239130434783, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651458, Length=362, Percent_Identity=33.7016574585635, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651456, Length=362, Percent_Identity=33.7016574585635, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45552010, Length=388, Percent_Identity=30.6701030927835, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24651462, Length=382, Percent_Identity=30.8900523560209, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24651464, Length=382, Percent_Identity=30.8900523560209, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 37971; Mature: 37971

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTWQNPDQPPPATPSTTEEQRTVTGMKRTTEKNLMVFSGRAHPVLAEEVATLLGTPLV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
PQSAYEFANSEIYVRYEESVRGCDAFVLQSHTAPVNEWIMEHLIMVDALKRASAKRITVV
CHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
MPFYGYARQDKKHKGREPISARLMADLFKTAGANRLITVDLHADQIQGFFDGPVDHLMAL
ECCCCCHHCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCCHHHHHHH
PILADYVRDKYGSQPLAVVSPDAGRIKVAERWSARLGGAPLAFIHKTRRTDRPNESVANR
HHHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
VVGDVSGRMCVLVDDMIDTGGTIVKAAEALMADGAAGVIIAATHAILSDPAVDRLKNCSA
HHHCCCCCEEEEEECHHCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHCCHHHHHHCCCCE
VEVVVTNTLPLAPECEFDKLTTLSIAPLISRAIREVFEDGSVTSMFE
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MNRTWQNPDQPPPATPSTTEEQRTVTGMKRTTEKNLMVFSGRAHPVLAEEVATLLGTPLV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
PQSAYEFANSEIYVRYEESVRGCDAFVLQSHTAPVNEWIMEHLIMVDALKRASAKRITVV
CHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
MPFYGYARQDKKHKGREPISARLMADLFKTAGANRLITVDLHADQIQGFFDGPVDHLMAL
ECCCCCHHCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCCHHHHHHH
PILADYVRDKYGSQPLAVVSPDAGRIKVAERWSARLGGAPLAFIHKTRRTDRPNESVANR
HHHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
VVGDVSGRMCVLVDDMIDTGGTIVKAAEALMADGAAGVIIAATHAILSDPAVDRLKNCSA
HHHCCCCCEEEEEECHHCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHCCHHHHHHCCCCE
VEVVVTNTLPLAPECEFDKLTTLSIAPLISRAIREVFEDGSVTSMFE
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]