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The map label for this gene is trpF

Identifier: 119386496

GI number: 119386496

Start: 924454

End: 925101

Strand: Direct

Name: trpF

Synonym: Pden_3789

Alternate gene names: 119386496

Gene position: 924454-925101 (Clockwise)

Preceding gene: 119386495

Following gene: 119386497

Centisome position: 53.43

GC content: 71.3

Gene sequence:

>648_bases
ATGGCCGTTTCCGTCAAGATCTGCGGCCTGACCGAGGCCGCGGGCCTCGCGGCGGCCGTCGACGCGGGCGCACGCTATGT
CGGCTTCGTCTTCTTTCCGAAATCCCCCCGCCATGTGACGCCCGGGACGGCGGCGGAGCTGGCCGCGCAAGTGCCGCTGG
GCGTGGCCAAGGTCGGGCTGTTCGTGAACCCCGATGACGCGGCGCTGGACGCGGTGCTGGCACATGTGCCCCTGGACGTG
ATCCAGTTGCACGGCGCCGAGACGCCCGCCCGCGTGGCCGAGGTCAAGGCGCGTACCGGCCTGCCGGTGATGAAGGCGGT
GGGCGTGGCCGATCCGCAGGATCTCGACGCGCTCTGGGATTACGGGCTGGTCGCCGACATGCTGCTGATCGACGCGAAAC
CGCCCAAGGATGCGGTGCTGCCGGGCGGCAACGGGCTTGCCTTCGACTGGCGGCTGCTGGCCGGGCGGCAGATCCTCAAG
CCCTGGCTGCTTGCCGGCGGCCTGACGCCCGAGAACGTGCATGAGGCGATCCGCCTGACCCGCGCGCCGGGCGTCGATGT
CTCCTCCGGCGTCGAAAGCGCGCCCGGCGTCAAGGATCCCGACCGCATCCGCAGCTTCATCGCCCGCGCCACGGCGCCGA
TCCTGTGA

Upstream 100 bases:

>100_bases
GCGCCGCGCGACGATGTGCTGGCGATCCTGGACGAGACGCGCAAGCCGGCGGCCGCCCCGGCGGGCACGGGTTCGACCCT
GCCGGCGCCGCGTTGATGCC

Downstream 100 bases:

>100_bases
CTGCCGGTCCCGTGACTGCCACCGTCGCCTTTCGCGAGGCCCGGCGCGACGAGGTTCCCGCCATCCTTGCGCTCCTGCGC
GACGACATGCTGGGTCAGGG

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MAVSVKICGLTEAAGLAAAVDAGARYVGFVFFPKSPRHVTPGTAAELAAQVPLGVAKVGLFVNPDDAALDAVLAHVPLDV
IQLHGAETPARVAEVKARTGLPVMKAVGVADPQDLDALWDYGLVADMLLIDAKPPKDAVLPGGNGLAFDWRLLAGRQILK
PWLLAGGLTPENVHEAIRLTRAPGVDVSSGVESAPGVKDPDRIRSFIARATAPIL

Sequences:

>Translated_215_residues
MAVSVKICGLTEAAGLAAAVDAGARYVGFVFFPKSPRHVTPGTAAELAAQVPLGVAKVGLFVNPDDAALDAVLAHVPLDV
IQLHGAETPARVAEVKARTGLPVMKAVGVADPQDLDALWDYGLVADMLLIDAKPPKDAVLPGGNGLAFDWRLLAGRQILK
PWLLAGGLTPENVHEAIRLTRAPGVDVSSGVESAPGVKDPDRIRSFIARATAPIL
>Mature_214_residues
AVSVKICGLTEAAGLAAAVDAGARYVGFVFFPKSPRHVTPGTAAELAAQVPLGVAKVGLFVNPDDAALDAVLAHVPLDVI
QLHGAETPARVAEVKARTGLPVMKAVGVADPQDLDALWDYGLVADMLLIDAKPPKDAVLPGGNGLAFDWRLLAGRQILKP
WLLAGGLTPENVHEAIRLTRAPGVDVSSGVESAPGVKDPDRIRSFIARATAPIL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=198, Percent_Identity=38.3838383838384, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320210, Length=225, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_PARDP (A1B8L1)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917551.1
- ProteinModelPortal:   A1B8L1
- SMR:   A1B8L1
- STRING:   A1B8L1
- GeneID:   4582340
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3789
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   A1B8L1
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22295; Mature: 22164

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVKICGLTEAAGLAAAVDAGARYVGFVFFPKSPRHVTPGTAAELAAQVPLGVAKVGL
CEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEHEEE
FVNPDDAALDAVLAHVPLDVIQLHGAETPARVAEVKARTGLPVMKAVGVADPQDLDALWD
EECCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
YGLVADMLLIDAKPPKDAVLPGGNGLAFDWRLLAGRQILKPWLLAGGLTPENVHEAIRLT
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHH
RAPGVDVSSGVESAPGVKDPDRIRSFIARATAPIL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVSVKICGLTEAAGLAAAVDAGARYVGFVFFPKSPRHVTPGTAAELAAQVPLGVAKVGL
EEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEHEEE
FVNPDDAALDAVLAHVPLDVIQLHGAETPARVAEVKARTGLPVMKAVGVADPQDLDALWD
EECCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
YGLVADMLLIDAKPPKDAVLPGGNGLAFDWRLLAGRQILKPWLLAGGLTPENVHEAIRLT
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHH
RAPGVDVSSGVESAPGVKDPDRIRSFIARATAPIL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA