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The map label for this gene is hisD2 [H]

Identifier: 119386288

GI number: 119386288

Start: 731289

End: 732599

Strand: Direct

Name: hisD2 [H]

Synonym: Pden_3579

Alternate gene names: 119386288

Gene position: 731289-732599 (Clockwise)

Preceding gene: 119386287

Following gene: 119386289

Centisome position: 42.27

GC content: 65.83

Gene sequence:

>1311_bases
ATGGCCATCACCTATCTGAAATCCGGCCGCAGCGACTCGGCCCGTGCCGAGGACGACCGCCGCACCCGCGAGACGGTCGA
GGCCGCGCTGGCCGACATTTCCGCGCGCGGCGACATTGCCGTGCGCGAAATGGCGGCGAAATTCGACGGCTACGCCCCGG
ACAGCTTCCGCCTGTCGCAGGATCAGATCGACGCGCTGATCGCGACGCTGACCCCGCGCGAGATCGAGGATATCCGCTTT
GCGCAGGCGCAGGTGCGCCGCTTTGCCCAGATCCAGCGCGATTCCATGAAGGATGTCGAGGTCGAGACCCTGCCGGGCGT
GGTCCTTGGCCACAAGCACATCCCCGTTCAGGCGGTGGGCTGCTATGTGCCGGGCGGCAAGTTCCCGATGGTGGCCTCGG
CGCATATGTCGATCCTGACCGCCTCGGTCGCGGGCGTGCCGCGCATCATCGCCGCGACCCCGCCCTTTCAGGGCAAGCCC
AATGCCGCCGTGATCGCCGCCATGCATTTCGCCGGCGCGCATGAGATCTATGTCCTCGGCGGTATCCAGGCCATCGGTGC
GATGGCGCTTGGCACCGAAACCATCGCCCCCGTCGATATGCTGGTCGGCCCCGGCAACGCCTTCGTGGCCGAGGCCAAGC
GGCAACTGTTCGGGCGCGTCGGCATCGATCTTTTCGCCGGTCCGACCGAGACGATGGTGATCGCCGACGACACCGTGGAC
GCCGAGCTTTGCGCGACCGATCTGCTGGGCCAGGCCGAACACGGCTATAACTCGCCCGCCGTGCTGGTGACGAATTCGCG
TGCGCTGGCCGAAGGCACGTTGGCCGAGATCGAACGGCTGCTGGCGATCTTGCCGACCGCCGTCACCGCCGCCGCGTCGT
GGCGCGACTACGGCGAGGTGATCCTGTGCGACACGCATGAAGAGATGTTGCAGGTCGCCAACGAGATCGCATCGGAACAT
GTGCAGGTGATGACCGACCGCGACGACTGGTATCTGGACAGCATGGTCGATTACGGCGCGCTGTTCCTTGGCCCGCGCAC
CCATGTCGCCAACGGCGACAAGGTGATCGGCACCAATCACACTTTGCCGACGCGCCGCGCCGGACGTTATACCGGCGGGC
TCTGGGTCGGGAAATTCATCAAGACCCACACCTATCAGCGCGTCCTGACGGATGACGCCGCCGCCGATATCGGCCGCTAT
TGCTCGCGCCTGTGCATGATCGAGGGCTTTGTCGGCCATGCCGAACAGGCCAATATCCGCGTGCGCCGCTATGGTGGCGA
CAACATTCCCTATGGCGAGGCCGCCCAATGA

Upstream 100 bases:

>100_bases
ATCGTCGAGGGGCTGGGCCTTGAGGTCGCGACCCCAGCCGAGGCGCGCGAGCTGCTGGCGCTAAAGGGTGGCGATCAGGT
CAATTTCTAAGGGAAAAATC

Downstream 100 bases:

>100_bases
CCCCGCTTCCCGATTTCTCGTTGAAGGGCAGGGTCGCGCTGGTCACCGGCGCCGGTCGCGGCATCGGGCGCGCCATCGCC
GAGGTCTATGCACAGGCGGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAITYLKSGRSDSARAEDDRRTRETVEAALADISARGDIAVREMAAKFDGYAPDSFRLSQDQIDALIATLTPREIEDIRF
AQAQVRRFAQIQRDSMKDVEVETLPGVVLGHKHIPVQAVGCYVPGGKFPMVASAHMSILTASVAGVPRIIAATPPFQGKP
NAAVIAAMHFAGAHEIYVLGGIQAIGAMALGTETIAPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETMVIADDTVD
AELCATDLLGQAEHGYNSPAVLVTNSRALAEGTLAEIERLLAILPTAVTAAASWRDYGEVILCDTHEEMLQVANEIASEH
VQVMTDRDDWYLDSMVDYGALFLGPRTHVANGDKVIGTNHTLPTRRAGRYTGGLWVGKFIKTHTYQRVLTDDAAADIGRY
CSRLCMIEGFVGHAEQANIRVRRYGGDNIPYGEAAQ

Sequences:

>Translated_436_residues
MAITYLKSGRSDSARAEDDRRTRETVEAALADISARGDIAVREMAAKFDGYAPDSFRLSQDQIDALIATLTPREIEDIRF
AQAQVRRFAQIQRDSMKDVEVETLPGVVLGHKHIPVQAVGCYVPGGKFPMVASAHMSILTASVAGVPRIIAATPPFQGKP
NAAVIAAMHFAGAHEIYVLGGIQAIGAMALGTETIAPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETMVIADDTVD
AELCATDLLGQAEHGYNSPAVLVTNSRALAEGTLAEIERLLAILPTAVTAAASWRDYGEVILCDTHEEMLQVANEIASEH
VQVMTDRDDWYLDSMVDYGALFLGPRTHVANGDKVIGTNHTLPTRRAGRYTGGLWVGKFIKTHTYQRVLTDDAAADIGRY
CSRLCMIEGFVGHAEQANIRVRRYGGDNIPYGEAAQ
>Mature_435_residues
AITYLKSGRSDSARAEDDRRTRETVEAALADISARGDIAVREMAAKFDGYAPDSFRLSQDQIDALIATLTPREIEDIRFA
QAQVRRFAQIQRDSMKDVEVETLPGVVLGHKHIPVQAVGCYVPGGKFPMVASAHMSILTASVAGVPRIIAATPPFQGKPN
AAVIAAMHFAGAHEIYVLGGIQAIGAMALGTETIAPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETMVIADDTVDA
ELCATDLLGQAEHGYNSPAVLVTNSRALAEGTLAEIERLLAILPTAVTAAASWRDYGEVILCDTHEEMLQVANEIASEHV
QVMTDRDDWYLDSMVDYGALFLGPRTHVANGDKVIGTNHTLPTRRAGRYTGGLWVGKFIKTHTYQRVLTDDAAADIGRYC
SRLCMIEGFVGHAEQANIRVRRYGGDNIPYGEAAQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=401, Percent_Identity=33.9152119700748, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319819, Length=411, Percent_Identity=33.8199513381995, Blast_Score=199, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47010; Mature: 46879

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITYLKSGRSDSARAEDDRRTRETVEAALADISARGDIAVREMAAKFDGYAPDSFRLSQ
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCH
DQIDALIATLTPREIEDIRFAQAQVRRFAQIQRDSMKDVEVETLPGVVLGHKHIPVQAVG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCCCCEEEEE
CYVPGGKFPMVASAHMSILTASVAGVPRIIAATPPFQGKPNAAVIAAMHFAGAHEIYVLG
EECCCCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEE
GIQAIGAMALGTETIAPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETMVIADDTVD
CHHHHHHHHHCCCCCCCHHEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCC
AELCATDLLGQAEHGYNSPAVLVTNSRALAEGTLAEIERLLAILPTAVTAAASWRDYGEV
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILCDTHEEMLQVANEIASEHVQVMTDRDDWYLDSMVDYGALFLGPRTHVANGDKVIGTNH
EEECCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCEEEECCCCCCCCCCEEEECCC
TLPTRRAGRYTGGLWVGKFIKTHTYQRVLTDDAAADIGRYCSRLCMIEGFVGHAEQANIR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VRRYGGDNIPYGEAAQ
EEEECCCCCCCCCCCC
>Mature Secondary Structure 
AITYLKSGRSDSARAEDDRRTRETVEAALADISARGDIAVREMAAKFDGYAPDSFRLSQ
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCH
DQIDALIATLTPREIEDIRFAQAQVRRFAQIQRDSMKDVEVETLPGVVLGHKHIPVQAVG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCCCCEEEEE
CYVPGGKFPMVASAHMSILTASVAGVPRIIAATPPFQGKPNAAVIAAMHFAGAHEIYVLG
EECCCCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEE
GIQAIGAMALGTETIAPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETMVIADDTVD
CHHHHHHHHHCCCCCCCHHEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCC
AELCATDLLGQAEHGYNSPAVLVTNSRALAEGTLAEIERLLAILPTAVTAAASWRDYGEV
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILCDTHEEMLQVANEIASEHVQVMTDRDDWYLDSMVDYGALFLGPRTHVANGDKVIGTNH
EEECCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCEEEECCCCCCCCCCEEEECCC
TLPTRRAGRYTGGLWVGKFIKTHTYQRVLTDDAAADIGRYCSRLCMIEGFVGHAEQANIR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VRRYGGDNIPYGEAAQ
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]