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The map label for this gene is tmk

Identifier: 119357439

GI number: 119357439

Start: 1865113

End: 1865772

Strand: Direct

Name: tmk

Synonym: Cpha266_1638

Alternate gene names: 119357439

Gene position: 1865113-1865772 (Clockwise)

Preceding gene: 119357438

Following gene: 119357440

Centisome position: 59.51

GC content: 47.12

Gene sequence:

>660_bases
ATGCTCATAACCTTTGAAGGAATCGATGGAGCCGGAAAATCCACGCAAATAAAAAAGCTTCAAACCGTGCTCAACAAAGC
GGGCGTGGAGTCGGTAACACTGCGGGAACCGGGCGGAACCGAAGTTGCAGAAAAAATCCGAAGCATTCTTCTCGAAAGCC
GCCACGAAATCAGCGCGGTCGGAGAACTTCTGCTGTTTTCGGCAACACGGGCAGAACTCGTTCAACAGGTAATCATCCCT
GCGCTGCAGACAGACGCCGTTGTTATCCTTGACAGATTTTATGATTCCACAAGGGCCTATCAGGGCTATGGACGCGGCAT
CGACCTCACTATTCTTGAAACGATCATCGCATTCTCGACGTTTAATCTGATACCTGACGTGACATTTTATCTTGACATCA
AGCCCGAGGATGCCATGATCAGAAAAAATTCAAAAAAATCTCTTCCGCTGGCATTCGAAAACAGTGATCTTGACCGGATG
GAAAGATCCGGTCTTGAGTTTTACAGCAAGGTCAGAAACGGCTATTTCGAAATAATCCGTTCAGAACAACACCGTTTTAA
AGTTTTGAATGCCCTTGAACACCCGGATGACCTTCACCGTCAGATCCTCGAAACGCTGCGAAAAAAAAAACCAGCTCTGA
AGGCACTCAACCGTTACTGA

Upstream 100 bases:

>100_bases
TTTCCGATTGCGGTCACTCGCCAATGCTCGAATACCCGGAAAAATTTTCAACGACGATCAGAGAGTTTATCTTTTCCGAA
ACCCATTTCCCAGGCAATCA

Downstream 100 bases:

>100_bases
GGCTTCACTATTACGGGTAAAAAGCTCTTTCGTCCGGGAATTCTTGTCGTTATTGCCCCTTACCTTTTTTATTTCAATAC
CACAAAAGTTTTTCACCGCA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLITFEGIDGAGKSTQIKKLQTVLNKAGVESVTLREPGGTEVAEKIRSILLESRHEISAVGELLLFSATRAELVQQVIIP
ALQTDAVVILDRFYDSTRAYQGYGRGIDLTILETIIAFSTFNLIPDVTFYLDIKPEDAMIRKNSKKSLPLAFENSDLDRM
ERSGLEFYSKVRNGYFEIIRSEQHRFKVLNALEHPDDLHRQILETLRKKKPALKALNRY

Sequences:

>Translated_219_residues
MLITFEGIDGAGKSTQIKKLQTVLNKAGVESVTLREPGGTEVAEKIRSILLESRHEISAVGELLLFSATRAELVQQVIIP
ALQTDAVVILDRFYDSTRAYQGYGRGIDLTILETIIAFSTFNLIPDVTFYLDIKPEDAMIRKNSKKSLPLAFENSDLDRM
ERSGLEFYSKVRNGYFEIIRSEQHRFKVLNALEHPDDLHRQILETLRKKKPALKALNRY
>Mature_219_residues
MLITFEGIDGAGKSTQIKKLQTVLNKAGVESVTLREPGGTEVAEKIRSILLESRHEISAVGELLLFSATRAELVQQVIIP
ALQTDAVVILDRFYDSTRAYQGYGRGIDLTILETIIAFSTFNLIPDVTFYLDIKPEDAMIRKNSKKSLPLAFENSDLDRM
ERSGLEFYSKVRNGYFEIIRSEQHRFKVLNALEHPDDLHRQILETLRKKKPALKALNRY

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=181, Percent_Identity=38.6740331491713, Blast_Score=117, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHLPD (A1BGY2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912083.1
- ProteinModelPortal:   A1BGY2
- SMR:   A1BGY2
- STRING:   A1BGY2
- GeneID:   4568583
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1638
- NMPDR:   fig|290317.7.peg.1720
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KSTHIAG
- ProtClustDB:   CLSK637698
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24884; Mature: 24884

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITFEGIDGAGKSTQIKKLQTVLNKAGVESVTLREPGGTEVAEKIRSILLESRHEISAV
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
GELLLFSATRAELVQQVIIPALQTDAVVILDRFYDSTRAYQGYGRGIDLTILETIIAFST
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FNLIPDVTFYLDIKPEDAMIRKNSKKSLPLAFENSDLDRMERSGLEFYSKVRNGYFEIIR
HHHCCCEEEEEEECCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
SEQHRFKVLNALEHPDDLHRQILETLRKKKPALKALNRY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MLITFEGIDGAGKSTQIKKLQTVLNKAGVESVTLREPGGTEVAEKIRSILLESRHEISAV
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
GELLLFSATRAELVQQVIIPALQTDAVVILDRFYDSTRAYQGYGRGIDLTILETIIAFST
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FNLIPDVTFYLDIKPEDAMIRKNSKKSLPLAFENSDLDRMERSGLEFYSKVRNGYFEIIR
HHHCCCEEEEEEECCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
SEQHRFKVLNALEHPDDLHRQILETLRKKKPALKALNRY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA