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The map label for this gene is pepA

Identifier: 119357339

GI number: 119357339

Start: 1745114

End: 1746625

Strand: Reverse

Name: pepA

Synonym: Cpha266_1537

Alternate gene names: 119357339

Gene position: 1746625-1745114 (Counterclockwise)

Preceding gene: 119357340

Following gene: 119357338

Centisome position: 55.73

GC content: 47.55

Gene sequence:

>1512_bases
ATGAAAATAGTTGTAACAAAAAGTGCCGTTAAAAAACTCGAAGCCGATATTCTTGCATTTCCTTTTTGTTCAGGAGAACT
CAAGAAGCAAGACGCAGGAGTGCTTTCGGATTTTGATATTTCCGCTCACGCGCTAAAGGACTTCAAGGCGGAATCAGGGG
AGATAGTGCTTTTCTATTCCTCTTCAGAAGGGCATCTGATAGCAAGGGTTGCACTGCTTGGTCTTGGGGACGGAAAAGAT
CCGGATGATTTTCGTAAAGCTGCTGCTTCACTTGCCGCAAAAGCCATGACAATGAATCTGCAACGAATTGCTGTGGATTG
TTCCCGTTTTGGAACTATTGCCGAGGACTCAAAAAAACGGGTCGGAAAACTTGCCGAAACGTTTGTGGAAGGCTGCTTTT
CGGGTTCCTACAAATTTGACAGGCTTAAAAGCGGTAAGCTGGATAAGAAGAAAGATGATAAAAAGGTAAAGGGCATCAGT
GAACTGATATTGAGATTCGATGCATCGGTGTTTGCCGATGCTGAAGAGGGCGCAGCCCAGGGAGAGATTGTCGGATCATG
TCAGTTGATGGCAAGAGATCTGGTCAATCTACCCGGCAATTATCTTCAGGCTGAGGATATTGCCAAGGCAGCGCAGGATT
CCGGCAGCAGGAACGGATTTGCCGTGAAGGTTTTGCGGAAAAAAGAGATGGAAGATCTTGCCATGGGAGGACTGCTTGCA
GTCAACCAGGGCAGTACACATCCGCCCACCTTCAGTATACTCGATTATAAACCTGAAGGAAAGGCAAAAGCTGTTGTCGC
CCTGGTAGGTAAAGGGGTTACTTTTGATTCCGGCGGTATTTCCCTGAAGCCTTCAGAGGGAATGGGCGAGATGAAGTCGG
ATATGTCCGGTGCGGCATGTGTTATTGCTGCGGTTGAGGCGGCGGCAAGACTTGGGCTTTCTCTGCGTGTGATAGGCTTG
ATTCCCGCTACCGACAATATGCCCGACGGTTCTGCCCAGAAACCTGGAGATGTTATTACAACCTATTCAGGTATTACCGT
CGAAGTTGGCAATACTGATGCGGAGGGTCGCCTTATTCTTGCCGATGCGTTGACCTATGCAAAGCAGGAATATAATCCTG
ATATTATTATTGATCTTGCCACGCTGACCGGAGCATGCATTGTTGCGCTTGGTTACTCTGTCGCAGGTCTTTTTTCCAAC
AACGATAAACTTGCCGAAGAGATTTATGCGGCAGGGATCTCTTCAGGGGAAAAAGTATGGCGGATGCCTCTTTGGGATGA
CTATGATGAACTTATCAAATCGGAAGTTGCGGATGTCAACAATACCGGAGGACGGGGTGCGGGATCGGTGACAGCGGCTA
AATTTCTCGAAAAGTTTATAGATGGCCATAAAAAATGGGCACATCTTGATATTGCCGGGCCGGCATTTCTGTCGAAAAGT
GGCGGTAAAGTGACCGGGGGAACCGGTTTCGGGGTTCGGCTTTTGATTGATTTATTGAAAAAATGGGCTTAA

Upstream 100 bases:

>100_bases
TTCCTCTGAAAGGGCACAGAAGGTGCTGCTTGATGACATCAGGGAGTTTCTCGAAAATCAGGAAGTTTTATTATAACCAG
GCGAAACCTACAGGTCTGTC

Downstream 100 bases:

>100_bases
AGCATACATTACAATCGACGGTTATGCGGTAACGCCTGTCATGTGCGCTGATATACAGAACAGCTTTGTCAACAAGGGAA
CCCCTTCATGTCAGCAGTAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKIVVTKSAVKKLEADILAFPFCSGELKKQDAGVLSDFDISAHALKDFKAESGEIVLFYSSSEGHLIARVALLGLGDGKD
PDDFRKAAASLAAKAMTMNLQRIAVDCSRFGTIAEDSKKRVGKLAETFVEGCFSGSYKFDRLKSGKLDKKKDDKKVKGIS
ELILRFDASVFADAEEGAAQGEIVGSCQLMARDLVNLPGNYLQAEDIAKAAQDSGSRNGFAVKVLRKKEMEDLAMGGLLA
VNQGSTHPPTFSILDYKPEGKAKAVVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAACVIAAVEAAARLGLSLRVIGL
IPATDNMPDGSAQKPGDVITTYSGITVEVGNTDAEGRLILADALTYAKQEYNPDIIIDLATLTGACIVALGYSVAGLFSN
NDKLAEEIYAAGISSGEKVWRMPLWDDYDELIKSEVADVNNTGGRGAGSVTAAKFLEKFIDGHKKWAHLDIAGPAFLSKS
GGKVTGGTGFGVRLLIDLLKKWA

Sequences:

>Translated_503_residues
MKIVVTKSAVKKLEADILAFPFCSGELKKQDAGVLSDFDISAHALKDFKAESGEIVLFYSSSEGHLIARVALLGLGDGKD
PDDFRKAAASLAAKAMTMNLQRIAVDCSRFGTIAEDSKKRVGKLAETFVEGCFSGSYKFDRLKSGKLDKKKDDKKVKGIS
ELILRFDASVFADAEEGAAQGEIVGSCQLMARDLVNLPGNYLQAEDIAKAAQDSGSRNGFAVKVLRKKEMEDLAMGGLLA
VNQGSTHPPTFSILDYKPEGKAKAVVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAACVIAAVEAAARLGLSLRVIGL
IPATDNMPDGSAQKPGDVITTYSGITVEVGNTDAEGRLILADALTYAKQEYNPDIIIDLATLTGACIVALGYSVAGLFSN
NDKLAEEIYAAGISSGEKVWRMPLWDDYDELIKSEVADVNNTGGRGAGSVTAAKFLEKFIDGHKKWAHLDIAGPAFLSKS
GGKVTGGTGFGVRLLIDLLKKWA
>Mature_503_residues
MKIVVTKSAVKKLEADILAFPFCSGELKKQDAGVLSDFDISAHALKDFKAESGEIVLFYSSSEGHLIARVALLGLGDGKD
PDDFRKAAASLAAKAMTMNLQRIAVDCSRFGTIAEDSKKRVGKLAETFVEGCFSGSYKFDRLKSGKLDKKKDDKKVKGIS
ELILRFDASVFADAEEGAAQGEIVGSCQLMARDLVNLPGNYLQAEDIAKAAQDSGSRNGFAVKVLRKKEMEDLAMGGLLA
VNQGSTHPPTFSILDYKPEGKAKAVVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAACVIAAVEAAARLGLSLRVIGL
IPATDNMPDGSAQKPGDVITTYSGITVEVGNTDAEGRLILADALTYAKQEYNPDIIIDLATLTGACIVALGYSVAGLFSN
NDKLAEEIYAAGISSGEKVWRMPLWDDYDELIKSEVADVNNTGGRGAGSVTAAKFLEKFIDGHKKWAHLDIAGPAFLSKS
GGKVTGGTGFGVRLLIDLLKKWA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=524, Percent_Identity=36.8320610687023, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI47155554, Length=320, Percent_Identity=33.125, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI1790710, Length=473, Percent_Identity=38.9006342494715, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=40.251572327044, Blast_Score=199, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=359, Percent_Identity=35.6545961002786, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17565172, Length=264, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129969, Length=308, Percent_Identity=35.0649350649351, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24662227, Length=310, Percent_Identity=33.8709677419355, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661038, Length=285, Percent_Identity=36.4912280701754, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355725, Length=285, Percent_Identity=36.140350877193, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355645, Length=333, Percent_Identity=32.4324324324324, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24662223, Length=333, Percent_Identity=32.4324324324324, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=34.1463414634146, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=34.1463414634146, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=34.2372881355932, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21357381, Length=318, Percent_Identity=33.0188679245283, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=33.0188679245283, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=33.0188679245283, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129963, Length=293, Percent_Identity=33.7883959044369, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24646701, Length=249, Percent_Identity=30.5220883534137, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646703, Length=249, Percent_Identity=30.5220883534137, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358201, Length=249, Percent_Identity=30.5220883534137, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHLPD (A1BGN2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911983.1
- ProteinModelPortal:   A1BGN2
- SMR:   A1BGN2
- STRING:   A1BGN2
- MEROPS:   M17.003
- GeneID:   4569122
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1537
- NMPDR:   fig|290317.7.peg.1619
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   SEGMGEM
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53197; Mature: 53197

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 283-283 ACT_SITE 357-357

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVTKSAVKKLEADILAFPFCSGELKKQDAGVLSDFDISAHALKDFKAESGEIVLFYS
CEEEEEHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEE
SSEGHLIARVALLGLGDGKDPDDFRKAAASLAAKAMTMNLQRIAVDCSRFGTIAEDSKKR
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGKLAETFVEGCFSGSYKFDRLKSGKLDKKKDDKKVKGISELILRFDASVFADAEEGAAQ
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCC
GEIVGSCQLMARDLVNLPGNYLQAEDIAKAAQDSGSRNGFAVKVLRKKEMEDLAMGGLLA
CCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCEEE
VNQGSTHPPTFSILDYKPEGKAKAVVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAAC
ECCCCCCCCEEEEEEECCCCCCEEEEEEEECCEEECCCCEEECCCCCCCHHHHCCCCHHH
VIAAVEAAARLGLSLRVIGLIPATDNMPDGSAQKPGDVITTYSGITVEVGNTDAEGRLIL
HHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCEEEEECCCCCCCCEEE
ADALTYAKQEYNPDIIIDLATLTGACIVALGYSVAGLFSNNDKLAEEIYAAGISSGEKVW
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCEEE
RMPLWDDYDELIKSEVADVNNTGGRGAGSVTAAKFLEKFIDGHKKWAHLDIAGPAFLSKS
ECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHCCCC
GGKVTGGTGFGVRLLIDLLKKWA
CCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIVVTKSAVKKLEADILAFPFCSGELKKQDAGVLSDFDISAHALKDFKAESGEIVLFYS
CEEEEEHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEE
SSEGHLIARVALLGLGDGKDPDDFRKAAASLAAKAMTMNLQRIAVDCSRFGTIAEDSKKR
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGKLAETFVEGCFSGSYKFDRLKSGKLDKKKDDKKVKGISELILRFDASVFADAEEGAAQ
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCC
GEIVGSCQLMARDLVNLPGNYLQAEDIAKAAQDSGSRNGFAVKVLRKKEMEDLAMGGLLA
CCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCEEE
VNQGSTHPPTFSILDYKPEGKAKAVVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAAC
ECCCCCCCCEEEEEEECCCCCCEEEEEEEECCEEECCCCEEECCCCCCCHHHHCCCCHHH
VIAAVEAAARLGLSLRVIGLIPATDNMPDGSAQKPGDVITTYSGITVEVGNTDAEGRLIL
HHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCEEEEECCCCCCCCEEE
ADALTYAKQEYNPDIIIDLATLTGACIVALGYSVAGLFSNNDKLAEEIYAAGISSGEKVW
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCEEE
RMPLWDDYDELIKSEVADVNNTGGRGAGSVTAAKFLEKFIDGHKKWAHLDIAGPAFLSKS
ECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHCCCC
GGKVTGGTGFGVRLLIDLLKKWA
CCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA