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The map label for this gene is trx2 [H]

Identifier: 119357012

GI number: 119357012

Start: 1357272

End: 1357601

Strand: Direct

Name: trx2 [H]

Synonym: Cpha266_1196

Alternate gene names: 119357012

Gene position: 1357272-1357601 (Clockwise)

Preceding gene: 119357011

Following gene: 119357013

Centisome position: 43.31

GC content: 43.94

Gene sequence:

>330_bases
ATGAGCGGAAAATATCTTGTCGCTACAGATCAGAATTTCAAAACCGAAATACTTGATTCAGATAAAGTTGCACTTGTGGA
TTTCTGGGCAGCCTGGTGCGGACCTTGCATGATGCTTGGCCCTGTTATCGAAGAACTTGCCGGCGATTATGAAGGCAAAG
CGATTGTTGCGAAACTCAATGTTGATGATAATCCGAATACAGCTTCGCAGTATGGCATAAGAAGCATTCCTACCATGCTG
CTTATCAAGAACGGCAAGGTTGTTGATCAGATGGTAGGCGCTATGCCGAAAAACATGATTGCAAAAAAAATCGACGAACA
CCTTGCCTGA

Upstream 100 bases:

>100_bases
AGCGCTCAGGATAGTAAAATGTTTTTTTTTTATTAGCTTCATTACTTATTTCTCAATGCATTACCTGAAAGAAAACTTCT
AATTTTAAACAAAAAGAACT

Downstream 100 bases:

>100_bases
ATCTGAAAAGATCGCTTTTTTTTCAGCACAGCACTTCTTACGGCGGTCATGACGTGAGCGGCAGCACCTCTCCGTTATTG
AAACATCTGCATGATCGACT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2 [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSGKYLVATDQNFKTEILDSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIVAKLNVDDNPNTASQYGIRSIPTML
LIKNGKVVDQMVGAMPKNMIAKKIDEHLA

Sequences:

>Translated_109_residues
MSGKYLVATDQNFKTEILDSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIVAKLNVDDNPNTASQYGIRSIPTML
LIKNGKVVDQMVGAMPKNMIAKKIDEHLA
>Mature_108_residues
SGKYLVATDQNFKTEILDSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIVAKLNVDDNPNTASQYGIRSIPTMLL
IKNGKVVDQMVGAMPKNMIAKKIDEHLA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=41.4634146341463, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=52.2935779816514, Blast_Score=127, Evalue=2e-31,
Organism=Escherichia coli, GI1788936, Length=108, Percent_Identity=37.962962962963, Blast_Score=90, Evalue=4e-20,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=39.2857142857143, Blast_Score=73, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=99, Percent_Identity=35.3535353535354, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=91, Percent_Identity=36.2637362637363, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510299, Length=107, Percent_Identity=37.3831775700935, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=32.5842696629214, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=89, Percent_Identity=32.5842696629214, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=89, Percent_Identity=37.0786516853933, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=101, Percent_Identity=33.6633663366337, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=38.5416666666667, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=45.4545454545455, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=104, Percent_Identity=38.4615384615385, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=35.4166666666667, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=39.5604395604396, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=38.75, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=38.75, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17530795, Length=85, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658597, Length=104, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=32.2916666666667, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=32.0388349514563, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11917; Mature: 11786

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKYLVATDQNFKTEILDSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIVAKLN
CCCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
VDDNPNTASQYGIRSIPTMLLIKNGKVVDQMVGAMPKNMIAKKIDEHLA
CCCCCCCHHHCCHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SGKYLVATDQNFKTEILDSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIVAKLN
CCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
VDDNPNTASQYGIRSIPTMLLIKNGKVVDQMVGAMPKNMIAKKIDEHLA
CCCCCCCHHHCCHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]