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The map label for this gene is fumC [H]

Identifier: 119357001

GI number: 119357001

Start: 1337532

End: 1338920

Strand: Direct

Name: fumC [H]

Synonym: Cpha266_1185

Alternate gene names: 119357001

Gene position: 1337532-1338920 (Clockwise)

Preceding gene: 119357000

Following gene: 119357002

Centisome position: 42.68

GC content: 52.48

Gene sequence:

>1389_bases
ATGCACTACCGGATTGAAAAAGATACTATGGGAGAAGTTCGTGTGCCGAAGGAGAAGTACTGGGGCGCACAGACCCAGCG
ATCGGTGGAGAATTTCAGGATAGGGCCTCCCGGTTCCATGCCGAGTGAGGTGATCAGGGCTTTTGGCTGCGTAAAAAAAG
CGGCGGCTATCACCAATTGCGAGCTTGGCGAGCTTTCGGTCGAAAAAATGAACGCTATCGCCATGGTGTGCGATGAAATT
ATTGCCGGAGAACTTGCCGAACATTTTCCTCTTGTTATTTGGCAGACCGGTTCAGGAACCCAGACCAACATGAATGTCAA
TGAGGTTATTGCCAACCGGGCTCATGTTCTTCTCGGCAACAGTATCGGTCACGGTTCGCTTCTGCTTCATCCTCATGATG
ATGTCAACAAATCCCAGTCATCTAACGATACTTTTCCGACAGCGATGCATATTGCAGCCTGCACCTCGCTGGCTACCATA
ACGTTGCCCGGATTGCGGCAGCTTCACAGCGAGCTCTCCCTCAAAGCCGAAGCATTCGGTTCGCTGGTGAAAATCGGAAG
AACCCATTTTATGGATGCCGTGCCGCTGACGCTCGGTCAGGAGTTTTCCGGCTATGCGTCACAGCTTGAGAAGGGTATTA
CGGCTCTCGTCACCTCAGTTTCGCCACTTTCGGAACTTGCGCTTGGTGCCACTGCCGTTGGAACAGGCCTGAATGCCCCG
AACGGGTTCGCTGCAAAGGCGGCGGATGCGATAGCTATGTTAACGGGACTGCCGTTTATCACGGCAGGAAATAAATTTGC
TGCGCTTGCTGCGCATGATGCGATGGTGGTTGCGCACGCCTCTTTAAAGAGCATTGCCGTTGTGCTTATGAAAATCACAA
ACGATATCAGGTTTCTTGCTTCGGGACCGCGTTGCGCAATAGGGGAGATTGTTCTTCCTTCCAATGAGCCGGGGTCGTCA
ATCATGCCCGGCAAGGTCAATCCGACACAGGCTGAAGCGCTCGCGATGATCTGCGCACAGGTCATGGGCAACGATGTTGT
CATGACGGTGGCCGGTTCGGGCGGCGTGCTTGAACTGAACACGTTCAAGCCGGTCATGATCGCCGCTTTTCTGCAGTCAG
CTCAACTCATCGGAGAGGGGTGCCGTTCATTTGCCGAAAAGTGCGTTCGAGGCATTTATCCTGATCACGAAAGAATGCAG
CGGCATCTCGAAAATTCGTTGATGCTGGTGACCGCTCTCAACGCTCATATCGGATATGAAAAATCGGCAACCATAGCACA
AAAAGCCTTTCGCGAAAAGACAACGCTTCGCGACGCTGCCGTATCAACGGGGTATGTTACCCATCAGCAGTTTGATGAGT
GGGTGAATCCCCAAAACATGATCGGCTGA

Upstream 100 bases:

>100_bases
AAACCTGTCGAAAACTTCTTGTAAAGGAGCATGGTGATTAGTTGTTGAGTAACGATGTAACGGTTTGTTGTGTCAAACGT
CAACAGAACTTTTTTCGATT

Downstream 100 bases:

>100_bases
AAACGGATGATTGAGAGGGATACTGCGATATACAGTGTTTTTATGTTACGCGTTGACGTAACATGCGTGTTGATAAATAA
CTTCCTGTTATCGTTGCGTT

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MHYRIEKDTMGEVRVPKEKYWGAQTQRSVENFRIGPPGSMPSEVIRAFGCVKKAAAITNCELGELSVEKMNAIAMVCDEI
IAGELAEHFPLVIWQTGSGTQTNMNVNEVIANRAHVLLGNSIGHGSLLLHPHDDVNKSQSSNDTFPTAMHIAACTSLATI
TLPGLRQLHSELSLKAEAFGSLVKIGRTHFMDAVPLTLGQEFSGYASQLEKGITALVTSVSPLSELALGATAVGTGLNAP
NGFAAKAADAIAMLTGLPFITAGNKFAALAAHDAMVVAHASLKSIAVVLMKITNDIRFLASGPRCAIGEIVLPSNEPGSS
IMPGKVNPTQAEALAMICAQVMGNDVVMTVAGSGGVLELNTFKPVMIAAFLQSAQLIGEGCRSFAEKCVRGIYPDHERMQ
RHLENSLMLVTALNAHIGYEKSATIAQKAFREKTTLRDAAVSTGYVTHQQFDEWVNPQNMIG

Sequences:

>Translated_462_residues
MHYRIEKDTMGEVRVPKEKYWGAQTQRSVENFRIGPPGSMPSEVIRAFGCVKKAAAITNCELGELSVEKMNAIAMVCDEI
IAGELAEHFPLVIWQTGSGTQTNMNVNEVIANRAHVLLGNSIGHGSLLLHPHDDVNKSQSSNDTFPTAMHIAACTSLATI
TLPGLRQLHSELSLKAEAFGSLVKIGRTHFMDAVPLTLGQEFSGYASQLEKGITALVTSVSPLSELALGATAVGTGLNAP
NGFAAKAADAIAMLTGLPFITAGNKFAALAAHDAMVVAHASLKSIAVVLMKITNDIRFLASGPRCAIGEIVLPSNEPGSS
IMPGKVNPTQAEALAMICAQVMGNDVVMTVAGSGGVLELNTFKPVMIAAFLQSAQLIGEGCRSFAEKCVRGIYPDHERMQ
RHLENSLMLVTALNAHIGYEKSATIAQKAFREKTTLRDAAVSTGYVTHQQFDEWVNPQNMIG
>Mature_462_residues
MHYRIEKDTMGEVRVPKEKYWGAQTQRSVENFRIGPPGSMPSEVIRAFGCVKKAAAITNCELGELSVEKMNAIAMVCDEI
IAGELAEHFPLVIWQTGSGTQTNMNVNEVIANRAHVLLGNSIGHGSLLLHPHDDVNKSQSSNDTFPTAMHIAACTSLATI
TLPGLRQLHSELSLKAEAFGSLVKIGRTHFMDAVPLTLGQEFSGYASQLEKGITALVTSVSPLSELALGATAVGTGLNAP
NGFAAKAADAIAMLTGLPFITAGNKFAALAAHDAMVVAHASLKSIAVVLMKITNDIRFLASGPRCAIGEIVLPSNEPGSS
IMPGKVNPTQAEALAMICAQVMGNDVVMTVAGSGGVLELNTFKPVMIAAFLQSAQLIGEGCRSFAEKCVRGIYPDHERMQ
RHLENSLMLVTALNAHIGYEKSATIAQKAFREKTTLRDAAVSTGYVTHQQFDEWVNPQNMIG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=57.4837310195228, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI266458395, Length=91, Percent_Identity=45.0549450549451, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=55.9912854030501, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=37.9609544468547, Blast_Score=315, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=56.0869565217391, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=56, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=53.7960954446855, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=56.5874730021598, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=56.5874730021598, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=55.0755939524838, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=54.7619047619048, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=48.9177489177489, Blast_Score=428, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49233; Mature: 49233

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYRIEKDTMGEVRVPKEKYWGAQTQRSVENFRIGPPGSMPSEVIRAFGCVKKAAAITNC
CCEECCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ELGELSVEKMNAIAMVCDEIIAGELAEHFPLVIWQTGSGTQTNMNVNEVIANRAHVLLGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHCCCEEEEEC
SIGHGSLLLHPHDDVNKSQSSNDTFPTAMHIAACTSLATITLPGLRQLHSELSLKAEAFG
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHH
SLVKIGRTHFMDAVPLTLGQEFSGYASQLEKGITALVTSVSPLSELALGATAVGTGLNAP
HHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHCCCCCCC
NGFAAKAADAIAMLTGLPFITAGNKFAALAAHDAMVVAHASLKSIAVVLMKITNDIRFLA
CCCHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHEEE
SGPRCAIGEIVLPSNEPGSSIMPGKVNPTQAEALAMICAQVMGNDVVMTVAGSGGVLELN
CCCCCEECEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
TFKPVMIAAFLQSAQLIGEGCRSFAEKCVRGIYPDHERMQRHLENSLMLVTALNAHIGYE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEEHHHHCCCC
KSATIAQKAFREKTTLRDAAVSTGYVTHQQFDEWVNPQNMIG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MHYRIEKDTMGEVRVPKEKYWGAQTQRSVENFRIGPPGSMPSEVIRAFGCVKKAAAITNC
CCEECCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ELGELSVEKMNAIAMVCDEIIAGELAEHFPLVIWQTGSGTQTNMNVNEVIANRAHVLLGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHCCCEEEEEC
SIGHGSLLLHPHDDVNKSQSSNDTFPTAMHIAACTSLATITLPGLRQLHSELSLKAEAFG
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHH
SLVKIGRTHFMDAVPLTLGQEFSGYASQLEKGITALVTSVSPLSELALGATAVGTGLNAP
HHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHCCCCCCC
NGFAAKAADAIAMLTGLPFITAGNKFAALAAHDAMVVAHASLKSIAVVLMKITNDIRFLA
CCCHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHEEE
SGPRCAIGEIVLPSNEPGSSIMPGKVNPTQAEALAMICAQVMGNDVVMTVAGSGGVLELN
CCCCCEECEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
TFKPVMIAAFLQSAQLIGEGCRSFAEKCVRGIYPDHERMQRHLENSLMLVTALNAHIGYE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEEHHHHCCCC
KSATIAQKAFREKTTLRDAAVSTGYVTHQQFDEWVNPQNMIG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA