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The map label for this gene is macA [H]

Identifier: 119356871

GI number: 119356871

Start: 1181072

End: 1182157

Strand: Direct

Name: macA [H]

Synonym: Cpha266_1044

Alternate gene names: 119356871

Gene position: 1181072-1182157 (Clockwise)

Preceding gene: 119356870

Following gene: 119356872

Centisome position: 37.69

GC content: 51.66

Gene sequence:

>1086_bases
ATGTTTGAGATTATGAAACGGAAAAGGATCCGGATTGCTCTGCTGCTTTTGGCAGTGGTTTCCCTGCTGTTCTGGTGGAT
GCAGTCCGGCCATAAGAGCGATAAGATGGAGAGTGGTTATAGCGGAAATTTTCCTGTGATGGCTGAAATCGTCAGAGTTG
CTTCAGTTCGTGACAGTTTCGGTGTGACGGGGAGTGTTCAGGCCTTGAGGGATGTGGAGGTATTCTCTGAAACGAGCGGC
ATTGTGCGAAAGGCATATGTGGAAGTTGGAGAAAAAAAGCAGGCTGGAGCGGTGCTGTTTCAGGTAGATGATGAATTGCA
GGCCTCGGCTGAACGTAAAGCGCGTCTCGCCTGTATTCAGGCAAAGAGAGATTACGAGCGTTATGCAAATCTCTATCAGG
AGGGAGCCGTGGCGCTTGGCAGTGTGGAACCTTTGAAGCTCAAGCTTGACGATGCAGAAGCCGATCTGATAACGGCAGGC
AGAAAATACCGGGATACAAAGATCAAGATGCCTGTTTCAGGGACGGTGACCGCAAGGTTTGTTGAAGAGGGAGAGATGGT
GCAGCCGGGCGTGAAAGTGGCCAATGTGGTCGATCTGTCGCAACTCAAAATCAGGTTTTATCTTTCCGAAAAACAGGTAC
TCATGGTTTCTTCCGGTTCTTTGATCAAGATAACGAGCGATCTCTATCCCGGCAGAATCTTTGCAGCAACGCTTTTTTCG
CTCAGCGGAAAAGCAGGCCGTGACCATACTTTTGAGGCTGAAGCGCGGATGGAGAACCCGCAGGCAACTCCTTTCAGGTC
AGGTATGTTTGTCAGGGTATCGGCTTCCGGGGCGGCGGAGCGGCAGTCGGTCGTTATTCCAAGAGCGGCTCTTGCAGGGA
GCATTCTCAATCCGCAGGTGTTTGTTGTTAACCTCGGTACGGCCAGGGTGCGAAATATCGTTGCAGGAAGCAGTTACGGT
ACATCAATCGAGGTGCTGTCAGGGCTGGTTCCCGGCGACAGCGTGGTCACGAGCGGTCAGAACGAGTTGCATGACGGCAT
GCAGGTTTCCGTTCTTCGTCAAACCGGTAAAGGGCCTGAAAAATGA

Upstream 100 bases:

>100_bases
TTTTTGTATCATGTATTCATGTGCTGTTTAGTATGAAAAAGGCGGGCCTTGTGCCCGCCTTTTTTTGTTTTTTAGCTGAT
AAAAGTCTGCAATAGAGACA

Downstream 100 bases:

>100_bases
CGCTTACCGAACTTTCCATCAAGCGCGCAAGTCTTGTTGTCGTTGTTTTTTCAGTGCTTGGTATCCTCGGCTTTTTCAGT
TATCAACAGTTGCAGTATGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MFEIMKRKRIRIALLLLAVVSLLFWWMQSGHKSDKMESGYSGNFPVMAEIVRVASVRDSFGVTGSVQALRDVEVFSETSG
IVRKAYVEVGEKKQAGAVLFQVDDELQASAERKARLACIQAKRDYERYANLYQEGAVALGSVEPLKLKLDDAEADLITAG
RKYRDTKIKMPVSGTVTARFVEEGEMVQPGVKVANVVDLSQLKIRFYLSEKQVLMVSSGSLIKITSDLYPGRIFAATLFS
LSGKAGRDHTFEAEARMENPQATPFRSGMFVRVSASGAAERQSVVIPRAALAGSILNPQVFVVNLGTARVRNIVAGSSYG
TSIEVLSGLVPGDSVVTSGQNELHDGMQVSVLRQTGKGPEK

Sequences:

>Translated_361_residues
MFEIMKRKRIRIALLLLAVVSLLFWWMQSGHKSDKMESGYSGNFPVMAEIVRVASVRDSFGVTGSVQALRDVEVFSETSG
IVRKAYVEVGEKKQAGAVLFQVDDELQASAERKARLACIQAKRDYERYANLYQEGAVALGSVEPLKLKLDDAEADLITAG
RKYRDTKIKMPVSGTVTARFVEEGEMVQPGVKVANVVDLSQLKIRFYLSEKQVLMVSSGSLIKITSDLYPGRIFAATLFS
LSGKAGRDHTFEAEARMENPQATPFRSGMFVRVSASGAAERQSVVIPRAALAGSILNPQVFVVNLGTARVRNIVAGSSYG
TSIEVLSGLVPGDSVVTSGQNELHDGMQVSVLRQTGKGPEK
>Mature_361_residues
MFEIMKRKRIRIALLLLAVVSLLFWWMQSGHKSDKMESGYSGNFPVMAEIVRVASVRDSFGVTGSVQALRDVEVFSETSG
IVRKAYVEVGEKKQAGAVLFQVDDELQASAERKARLACIQAKRDYERYANLYQEGAVALGSVEPLKLKLDDAEADLITAG
RKYRDTKIKMPVSGTVTARFVEEGEMVQPGVKVANVVDLSQLKIRFYLSEKQVLMVSSGSLIKITSDLYPGRIFAATLFS
LSGKAGRDHTFEAEARMENPQATPFRSGMFVRVSASGAAERQSVVIPRAALAGSILNPQVFVVNLGTARVRNIVAGSSYG
TSIEVLSGLVPGDSVVTSGQNELHDGMQVSVLRQTGKGPEK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39301; Mature: 39301

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEIMKRKRIRIALLLLAVVSLLFWWMQSGHKSDKMESGYSGNFPVMAEIVRVASVRDSF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GVTGSVQALRDVEVFSETSGIVRKAYVEVGEKKQAGAVLFQVDDELQASAERKARLACIQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
AKRDYERYANLYQEGAVALGSVEPLKLKLDDAEADLITAGRKYRDTKIKMPVSGTVTARF
HHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCHHHHCCCCCCCCEEEECCCCCEEEEE
VEEGEMVQPGVKVANVVDLSQLKIRFYLSEKQVLMVSSGSLIKITSDLYPGRIFAATLFS
ECCCCCCCCCCHHHHEEEHHHEEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHH
LSGKAGRDHTFEAEARMENPQATPFRSGMFVRVSASGAAERQSVVIPRAALAGSILNPQV
HCCCCCCCCCEEHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEECHHHHHCCCCCCEE
FVVNLGTARVRNIVAGSSYGTSIEVLSGLVPGDSVVTSGQNELHDGMQVSVLRQTGKGPE
EEEECCHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEECCCHHHHCCCEEEEEHHCCCCCC
K
C
>Mature Secondary Structure
MFEIMKRKRIRIALLLLAVVSLLFWWMQSGHKSDKMESGYSGNFPVMAEIVRVASVRDSF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GVTGSVQALRDVEVFSETSGIVRKAYVEVGEKKQAGAVLFQVDDELQASAERKARLACIQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
AKRDYERYANLYQEGAVALGSVEPLKLKLDDAEADLITAGRKYRDTKIKMPVSGTVTARF
HHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCHHHHCCCCCCCCEEEECCCCCEEEEE
VEEGEMVQPGVKVANVVDLSQLKIRFYLSEKQVLMVSSGSLIKITSDLYPGRIFAATLFS
ECCCCCCCCCCHHHHEEEHHHEEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHH
LSGKAGRDHTFEAEARMENPQATPFRSGMFVRVSASGAAERQSVVIPRAALAGSILNPQV
HCCCCCCCCCEEHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEECHHHHHCCCCCCEE
FVVNLGTARVRNIVAGSSYGTSIEVLSGLVPGDSVVTSGQNELHDGMQVSVLRQTGKGPE
EEEECCHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEECCCHHHHCCCEEEEEHHCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]