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The map label for this gene is nuoN [H]

Identifier: 119356799

GI number: 119356799

Start: 1112383

End: 1113918

Strand: Direct

Name: nuoN [H]

Synonym: Cpha266_0971

Alternate gene names: 119356799

Gene position: 1112383-1113918 (Clockwise)

Preceding gene: 119356798

Following gene: 119356800

Centisome position: 35.5

GC content: 44.73

Gene sequence:

>1536_bases
ATGTTCGAGCTGCCATCGGGTGCTGAGATCCAGAGTGTCATTGCAGGTATAAAAGCAAGTGTCGGTTATTTTATTCCTGA
AATATATCTCTCTGTGCTTTTTATGGTTCTGATCATTGTCGATCTGATCGTAAAGGGGAAAAAAAATACACTGTTACCAG
TCATCACCATAACTGGTCTTGCCGGAAGCTTCTTCTTCATCTATCAGCAGCACGCTATGACTGCCGGCGAGATGTTTTTC
GGCATGTACGTCCTTGATGAATTTGCTCTGTTCTTTAAGTACTTTTTTGTGCTTTCCGGTATACTTGCTGCGTTGATCTC
AATGGATGATGAGTATCTGAACAGGGAGAGTTCCGGCATGGGGGAGTATTACTCTCTTGTTGTTGCGATGGTTATCGGTA
TGATCATGATGGCTGCAGCAACAGACCTGCTCATGATTTTCCTCTCGATGGAACTTGTCGGTCTGACCGCTTATGTGCTG
ACCGGCTATCTGAAACGCGATCCCCGCTCTTCGGAAGCCGCGCTTAAATATCTGATTTACGGTGCAGTCTCTACCGGTTT
GATGATCTACGGGTTTTCACTGATTTATGGTATAACCGGTGAAACAAATATTTTCAGAATAAGCGAGGAGTTGCGGCTTC
ACAGCAGCGATCCACTCGTCATGATGATAGCAACCCTGTTCATACTTGCCGGATTCGGTTACAAGATTGGCGCAGTTCCT
TTTCATTTCTGGACTCCCGATGTCTATGAAGGCTCACCAACCCCCATTACAGCCTATCTCTCCATTGCATCCAAGGCCGC
AGGATTTGCCGTACTCATGAGATTTTTTCTGACAGCCCTTCCTCATGGAGGAGCTGCATACGATAACATAATCAGTAATA
ACTGGGTGCTTCTTCTGATCATCCTTTCGATTTCTTCAATGATATACGGTAACGTCGTGGCTCTCTGGCAGCAGAATGTC
AAAAGGATGCTGGCCTATTCATCCATAGCGCATGCCGGTTATCTTCTGCTCGGCGTTATCATGATGGATGAACTCGGTAC
ACAGGCAACACTGTTTTATCTGCTTTCATACCTCTTGATGAACATCGGAGCTTTTTATGTCGTTATCCTTATTTCAAATA
AAACCGGCAGCGAAAATCTCGACGATTATCGCGGGCTTGGTAAAAAAATGCCTCTTGCAGGCGCGGCACTGACGGTTTTT
CTCATCTCTCTTGTCGGCCTGCCTCCAACAGTTGGCTTTATTGGAAAGCTTATGATTTTCACCGCTATGCTTGCCAAAGG
ATCAATCTATATCTGGCTTGCTCTTATCGGCGTTCTTACAAGCGTTATTTCTCTTTACTACTACATGCTCATTCCTCTGA
ACATGTATCTCAGGGAGTCTTTGGAACCACATAAAGAGAGTCTGAACGTTGGTCTTCTTTCCCGGATCATCATGGCCATA
TTCATGATTCTTACTCTTTATTTCGGTCTCTTTTTCACGCCGCTCTCTGATTTTGCAAAGTATTCATCAGCGCTGTTCGG
CAATACTGTTTATTAA

Upstream 100 bases:

>100_bases
GACAAGTATTAACAAACTGGTTGAAGTGTTGTCTCCTGTCGTGATGACGGCCCTGAATTAACCAGACGAAAAGAGCTAAA
AAGAATAAACGAAGAGAATT

Downstream 100 bases:

>100_bases
CAGTTTTCGACTCCTTATCCGCCTGTCGAATTTATCTTGCTCTTCAAGATTCATATCTGCTTTAAACATGTCCCGATCAA
TCGGGACATGTCCGTTTACG

Product: proton-translocating NADH-quinone oxidoreductase, chain N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MFELPSGAEIQSVIAGIKASVGYFIPEIYLSVLFMVLIIVDLIVKGKKNTLLPVITITGLAGSFFFIYQQHAMTAGEMFF
GMYVLDEFALFFKYFFVLSGILAALISMDDEYLNRESSGMGEYYSLVVAMVIGMIMMAAATDLLMIFLSMELVGLTAYVL
TGYLKRDPRSSEAALKYLIYGAVSTGLMIYGFSLIYGITGETNIFRISEELRLHSSDPLVMMIATLFILAGFGYKIGAVP
FHFWTPDVYEGSPTPITAYLSIASKAAGFAVLMRFFLTALPHGGAAYDNIISNNWVLLLIILSISSMIYGNVVALWQQNV
KRMLAYSSIAHAGYLLLGVIMMDELGTQATLFYLLSYLLMNIGAFYVVILISNKTGSENLDDYRGLGKKMPLAGAALTVF
LISLVGLPPTVGFIGKLMIFTAMLAKGSIYIWLALIGVLTSVISLYYYMLIPLNMYLRESLEPHKESLNVGLLSRIIMAI
FMILTLYFGLFFTPLSDFAKYSSALFGNTVY

Sequences:

>Translated_511_residues
MFELPSGAEIQSVIAGIKASVGYFIPEIYLSVLFMVLIIVDLIVKGKKNTLLPVITITGLAGSFFFIYQQHAMTAGEMFF
GMYVLDEFALFFKYFFVLSGILAALISMDDEYLNRESSGMGEYYSLVVAMVIGMIMMAAATDLLMIFLSMELVGLTAYVL
TGYLKRDPRSSEAALKYLIYGAVSTGLMIYGFSLIYGITGETNIFRISEELRLHSSDPLVMMIATLFILAGFGYKIGAVP
FHFWTPDVYEGSPTPITAYLSIASKAAGFAVLMRFFLTALPHGGAAYDNIISNNWVLLLIILSISSMIYGNVVALWQQNV
KRMLAYSSIAHAGYLLLGVIMMDELGTQATLFYLLSYLLMNIGAFYVVILISNKTGSENLDDYRGLGKKMPLAGAALTVF
LISLVGLPPTVGFIGKLMIFTAMLAKGSIYIWLALIGVLTSVISLYYYMLIPLNMYLRESLEPHKESLNVGLLSRIIMAI
FMILTLYFGLFFTPLSDFAKYSSALFGNTVY
>Mature_511_residues
MFELPSGAEIQSVIAGIKASVGYFIPEIYLSVLFMVLIIVDLIVKGKKNTLLPVITITGLAGSFFFIYQQHAMTAGEMFF
GMYVLDEFALFFKYFFVLSGILAALISMDDEYLNRESSGMGEYYSLVVAMVIGMIMMAAATDLLMIFLSMELVGLTAYVL
TGYLKRDPRSSEAALKYLIYGAVSTGLMIYGFSLIYGITGETNIFRISEELRLHSSDPLVMMIATLFILAGFGYKIGAVP
FHFWTPDVYEGSPTPITAYLSIASKAAGFAVLMRFFLTALPHGGAAYDNIISNNWVLLLIILSISSMIYGNVVALWQQNV
KRMLAYSSIAHAGYLLLGVIMMDELGTQATLFYLLSYLLMNIGAFYVVILISNKTGSENLDDYRGLGKKMPLAGAALTVF
LISLVGLPPTVGFIGKLMIFTAMLAKGSIYIWLALIGVLTSVISLYYYMLIPLNMYLRESLEPHKESLNVGLLSRIIMAI
FMILTLYFGLFFTPLSDFAKYSSALFGNTVY

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=349, Percent_Identity=24.3553008595989, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=477, Percent_Identity=32.2851153039832, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1788831, Length=372, Percent_Identity=29.0322580645161, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1788614, Length=503, Percent_Identity=26.2425447316103, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788829, Length=368, Percent_Identity=26.6304347826087, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788613, Length=332, Percent_Identity=25.3012048192771, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788827, Length=319, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI2367154, Length=310, Percent_Identity=26.4516129032258, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56440; Mature: 56440

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELPSGAEIQSVIAGIKASVGYFIPEIYLSVLFMVLIIVDLIVKGKKNTLLPVITITGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHC
AGSFFFIYQQHAMTAGEMFFGMYVLDEFALFFKYFFVLSGILAALISMDDEYLNRESSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
GEYYSLVVAMVIGMIMMAAATDLLMIFLSMELVGLTAYVLTGYLKRDPRSSEAALKYLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GAVSTGLMIYGFSLIYGITGETNIFRISEELRLHSSDPLVMMIATLFILAGFGYKIGAVP
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCE
FHFWTPDVYEGSPTPITAYLSIASKAAGFAVLMRFFLTALPHGGAAYDNIISNNWVLLLI
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHH
ILSISSMIYGNVVALWQQNVKRMLAYSSIAHAGYLLLGVIMMDELGTQATLFYLLSYLLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NIGAFYVVILISNKTGSENLDDYRGLGKKMPLAGAALTVFLISLVGLPPTVGFIGKLMIF
HHHHHEEEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAMLAKGSIYIWLALIGVLTSVISLYYYMLIPLNMYLRESLEPHKESLNVGLLSRIIMAI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHH
FMILTLYFGLFFTPLSDFAKYSSALFGNTVY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFELPSGAEIQSVIAGIKASVGYFIPEIYLSVLFMVLIIVDLIVKGKKNTLLPVITITGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHC
AGSFFFIYQQHAMTAGEMFFGMYVLDEFALFFKYFFVLSGILAALISMDDEYLNRESSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
GEYYSLVVAMVIGMIMMAAATDLLMIFLSMELVGLTAYVLTGYLKRDPRSSEAALKYLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GAVSTGLMIYGFSLIYGITGETNIFRISEELRLHSSDPLVMMIATLFILAGFGYKIGAVP
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCE
FHFWTPDVYEGSPTPITAYLSIASKAAGFAVLMRFFLTALPHGGAAYDNIISNNWVLLLI
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHH
ILSISSMIYGNVVALWQQNVKRMLAYSSIAHAGYLLLGVIMMDELGTQATLFYLLSYLLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NIGAFYVVILISNKTGSENLDDYRGLGKKMPLAGAALTVFLISLVGLPPTVGFIGKLMIF
HHHHHEEEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAMLAKGSIYIWLALIGVLTSVISLYYYMLIPLNMYLRESLEPHKESLNVGLLSRIIMAI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHH
FMILTLYFGLFFTPLSDFAKYSSALFGNTVY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA