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The map label for this gene is mtnA

Identifier: 118578949

GI number: 118578949

Start: 534511

End: 535551

Strand: Direct

Name: mtnA

Synonym: Ppro_0510

Alternate gene names: 118578949

Gene position: 534511-535551 (Clockwise)

Preceding gene: 118578941

Following gene: 118578950

Centisome position: 13.34

GC content: 66.47

Gene sequence:

>1041_bases
ATGTCCTTCCGCACCATCGAGTGGCGCGACGACAGCGTCATCATGATCGACCAGACCCGCCTGCCGGGTGAAGAGGTCTA
CAACACCTATACCGATTTCAAGGCGGTTGCCGAAGCCATTCGCGGCATGGTCATCCGCGGGGCTCCCGCCATCGGCGTGG
CCGCCGCCATGGGGATCGCCCTGGGGGCCCGGGACATCATCGCCGATACCCATGAATCCTTCTTCCGCCAGCTGGAGAAC
GTGTGCGACGTCATGGCCCGCACCCGTCCCACGGCGGTCAACCTGTTCTGGGCCATCGAGCGCATGAAGCGTGTGGCCGA
GGCGGGTCGTGACAAGCCGCTGGACGGGATCCGCCAACTGCTCAAAGAGGAGGCCATCCGGGTGGAAGAGGAGGACCTGA
CCATCTGCCGCAACATCGGCAAGTGGGGGGCTACCCTGATCCCCGAGGGGGCAACGGTCCTGACCCACTGCAATGCCGGC
GGCCTGGCCACGGCCGGCTACGGCACCGCCCTGGGGGTGATCCGGGCCGCCCACGAGGCGGGGAAGAAGATCCAGGTCTT
TGCCGACGAGACCCGCCCCTGGCTGCAGGGCGCCCGCCTGACCGCCTGGGAACTGGTCAAGGAGGGGATCCCCGCCACAT
TGATCTCCGACAACATGGCCGGCTTCTTCATGAGTAGGGGGGAGATCACCTGCTGCGTGGTGGGGGCCGACCGTATCGCC
GCCAACGGCGATACGGCCAACAAGATCGGCACCTATTCGGTGGCGGTGCTGGCCAAGGAGAACAACATCCCCTTCTATGT
GGCCGCCCCGATCTCAACCCTGGACTTAAGCCTCTGCGACGGCGGCAAGATTCCCATCGAGGAGCGCCCGGCCGAGGAGG
TGACCTGCATCAGGGGGGTCGACATCGCCCCCGCCGGGGTCAGGGTACGCAACCCGGCCTTCGACGTCACCCCGGCCCGC
TACATCAGCGCCATCATCACCGAGAACGGCATCGTCAGGGGCGACTACCGCGCAGGCCTGCGCAGGATCGCGGGGAACTG
A

Upstream 100 bases:

>100_bases
CCGGGTGCCTTTGTCGTTGCCTGAATCTGCGGCACCATGATACAAGAAACGACGATTGACAGCTTCTTTTTCACCACCAG
CAACCAAAGGAGCACGAGCC

Downstream 100 bases:

>100_bases
CATGCGTCTCTTGCGCTTCCTGCACGAGTTCAGCCGGATCGTCTCCCTGGACGATCCGGCCCGGCGCACGGAGCGGTTGG
CCGCCTTCCTGGAGCGGCAC

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSFRTIEWRDDSVIMIDQTRLPGEEVYNTYTDFKAVAEAIRGMVIRGAPAIGVAAAMGIALGARDIIADTHESFFRQLEN
VCDVMARTRPTAVNLFWAIERMKRVAEAGRDKPLDGIRQLLKEEAIRVEEEDLTICRNIGKWGATLIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHEAGKKIQVFADETRPWLQGARLTAWELVKEGIPATLISDNMAGFFMSRGEITCCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPISTLDLSLCDGGKIPIEERPAEEVTCIRGVDIAPAGVRVRNPAFDVTPAR
YISAIITENGIVRGDYRAGLRRIAGN

Sequences:

>Translated_346_residues
MSFRTIEWRDDSVIMIDQTRLPGEEVYNTYTDFKAVAEAIRGMVIRGAPAIGVAAAMGIALGARDIIADTHESFFRQLEN
VCDVMARTRPTAVNLFWAIERMKRVAEAGRDKPLDGIRQLLKEEAIRVEEEDLTICRNIGKWGATLIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHEAGKKIQVFADETRPWLQGARLTAWELVKEGIPATLISDNMAGFFMSRGEITCCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPISTLDLSLCDGGKIPIEERPAEEVTCIRGVDIAPAGVRVRNPAFDVTPAR
YISAIITENGIVRGDYRAGLRRIAGN
>Mature_345_residues
SFRTIEWRDDSVIMIDQTRLPGEEVYNTYTDFKAVAEAIRGMVIRGAPAIGVAAAMGIALGARDIIADTHESFFRQLENV
CDVMARTRPTAVNLFWAIERMKRVAEAGRDKPLDGIRQLLKEEAIRVEEEDLTICRNIGKWGATLIPEGATVLTHCNAGG
LATAGYGTALGVIRAAHEAGKKIQVFADETRPWLQGARLTAWELVKEGIPATLISDNMAGFFMSRGEITCCVVGADRIAA
NGDTANKIGTYSVAVLAKENNIPFYVAAPISTLDLSLCDGGKIPIEERPAEEVTCIRGVDIAPAGVRVRNPAFDVTPARY
ISAIITENGIVRGDYRAGLRRIAGN

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=352, Percent_Identity=44.6022727272727, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI23943880, Length=338, Percent_Identity=38.7573964497041, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI78000156, Length=345, Percent_Identity=23.1884057971014, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI78000158, Length=345, Percent_Identity=23.1884057971014, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI187607323, Length=345, Percent_Identity=23.1884057971014, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4503503, Length=138, Percent_Identity=36.231884057971, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557462, Length=321, Percent_Identity=37.6947040498442, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17557123, Length=196, Percent_Identity=27.0408163265306, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=392, Percent_Identity=34.9489795918367, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322878, Length=209, Percent_Identity=30.622009569378, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357667, Length=350, Percent_Identity=41.4285714285714, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24651647, Length=350, Percent_Identity=41.4285714285714, Blast_Score=254, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_PELPD (A1ALC1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900199.1
- ProteinModelPortal:   A1ALC1
- SMR:   A1ALC1
- STRING:   A1ALC1
- GeneID:   4572881
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0510
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   A1ALC1
- ProtClustDB:   CLSK829258
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37448; Mature: 37317

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 89-89 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRTIEWRDDSVIMIDQTRLPGEEVYNTYTDFKAVAEAIRGMVIRGAPAIGVAAAMGIA
CCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
LGARDIIADTHESFFRQLENVCDVMARTRPTAVNLFWAIERMKRVAEAGRDKPLDGIRQL
HCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKEEAIRVEEEDLTICRNIGKWGATLIPEGATVLTHCNAGGLATAGYGTALGVIRAAHEA
HHHHHHCCCHHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHC
GKKIQVFADETRPWLQGARLTAWELVKEGIPATLISDNMAGFFMSRGEITCCVVGADRIA
CCEEEEEECCCCHHHCCCCHHHHHHHHCCCCEEEECCCCHHEEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPISTLDLSLCDGGKIPIEERPAEEVTCIRGV
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHEECCC
DIAPAGVRVRNPAFDVTPARYISAIITENGIVRGDYRAGLRRIAGN
CCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHCCC
>Mature Secondary Structure 
SFRTIEWRDDSVIMIDQTRLPGEEVYNTYTDFKAVAEAIRGMVIRGAPAIGVAAAMGIA
CCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
LGARDIIADTHESFFRQLENVCDVMARTRPTAVNLFWAIERMKRVAEAGRDKPLDGIRQL
HCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKEEAIRVEEEDLTICRNIGKWGATLIPEGATVLTHCNAGGLATAGYGTALGVIRAAHEA
HHHHHHCCCHHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHC
GKKIQVFADETRPWLQGARLTAWELVKEGIPATLISDNMAGFFMSRGEITCCVVGADRIA
CCEEEEEECCCCHHHCCCCHHHHHHHHCCCCEEEECCCCHHEEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPISTLDLSLCDGGKIPIEERPAEEVTCIRGV
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHEECCC
DIAPAGVRVRNPAFDVTPARYISAIITENGIVRGDYRAGLRRIAGN
CCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA