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The map label for this gene is glmU

Identifier: 118578940

GI number: 118578940

Start: 523720

End: 525102

Strand: Direct

Name: glmU

Synonym: Ppro_0501

Alternate gene names: 118578940

Gene position: 523720-525102 (Clockwise)

Preceding gene: 118578937

Following gene: 118578941

Centisome position: 13.07

GC content: 64.71

Gene sequence:

>1383_bases
ATGGAGAATGTCGCAGCCATCATCCTTGCTGCGGGCAAGGGAACCCGCATGAAATCCGGGCTGGTCAAGGTGCTTCACCC
CATAGCGGGACGACCGATGATTGACTGGCCGCTGGAGGCTGCCCGTGGAGCGGGGGCCGCGCCGGTGGTGCTGGTGGTGG
GGCATCAGGCCGAGGCGGTACGGGAGAGATTTCAGGGGGCAGGGGATATCGCCTGTGCCCTGCAGGCCGAGCAGTTGGGC
ACCGGCCATGCCGTTGCTTGCGCGGCTCCGGCCCTGGCCGGCTTTTCCGGTACGGTGCTGATCCTCTGCGGCGACACGCC
GCTTTTACGCGGCGGAACTCTGACTGACCTGCTCGCCTTCCACCGCTCGCAGGGAGCGGCGGTCACGGTGCTGACCGCCC
GCATGGAAAACCCCCACGGCTACGGCCGGGTGCTGCGGGACGAGGCGGGACGGGTGCTGCGCATCGTGGAGCAGAAGGAC
GCCAGCCCGCAAGAGTGCTCCGTCCGCGAGATCAACAGCGGCATCTACTGCATGGAAGCCGGTTTCCTGTTCGACAACAT
CGGTTCCTTAGGCAACGATAACGCCCAGAACGAATTTTACCTGACCGACCTGGTGGCCATGGCTGCCCAGAAGGGGGCGA
CCTGCCTGGCCATGGCCATCGAAGACAGTGACGAGATCATGGGGGTCAATGACCGCGCCCAACTGGCCCAGGCGGCCCGC
ATCCTGCGCCGGCGCATCAACCGCGACCTGATGCTCTCCGGCGTGTCGCTGGTCGATCCGGAGCAGACCTACATCGACCA
GGGGGTCGTTATCGGCCCGGATACGCTGATCCACCCCAACTGCTCCATCAGCGGCCCTACGCAGATCGGCAACGGATGCC
AGATCGAAAGCGGCGTCTCCATATCCTCCTGCCGCATCGGTGACCGCTGCCGCATCAAGGCCGGCTCGGTGCTGGAGGAT
TCGGAGCTCCGCGCGGATGTGGCCGTGGGGCCCATGGCCCATCTGCGCCCCGGAACGGTGCTGAACGACCACGTCAAAAT
CGGCAATTTCGTGGAAACCAAGAAGACGGTCATGGGCGAGGGATCCAAGGCTTCCCACCTGACCTATCTGGGGGACGCCG
AGATCGGACGCGACGTGAACATCGGCTGCGGCACGATCACCTGCAATTACGATGGCGTTAAAAAGCACCGCACCCTGATC
GGCGACAACGTGTTCGTCGGCAGTGACGTGCAACTGGTGGCGCCGGTCAGGGTGGGGGCCGACTCACTGATCGCCGCCGG
CACGACCGTGACGCGTGATGTCCCTGCCGGTTCCCTGGCCATCAGCCGCACCCCCCAGGTGAACAGGGAAGGGTGGCGCA
TCAGGATGAAAAAGAAAACATGA

Upstream 100 bases:

>100_bases
GTCCTAATCGGCGCATATTGACTTGACGCTGGTTCGGGCATCGCATAAACTGATTCGCGCTTATACATTAATACTCTTTA
TGATAGGAATGGACGATACC

Downstream 100 bases:

>100_bases
ATTCCCTGCTTCGGAAGGGGAACAGCGGAATGTGGCGCGGAGAACGACCGTGACGAGACTTGAGCGGCAGAGCAGCGCAC
GCACCAGAATCCTGATCGTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MENVAAIILAAGKGTRMKSGLVKVLHPIAGRPMIDWPLEAARGAGAAPVVLVVGHQAEAVRERFQGAGDIACALQAEQLG
TGHAVACAAPALAGFSGTVLILCGDTPLLRGGTLTDLLAFHRSQGAAVTVLTARMENPHGYGRVLRDEAGRVLRIVEQKD
ASPQECSVREINSGIYCMEAGFLFDNIGSLGNDNAQNEFYLTDLVAMAAQKGATCLAMAIEDSDEIMGVNDRAQLAQAAR
ILRRRINRDLMLSGVSLVDPEQTYIDQGVVIGPDTLIHPNCSISGPTQIGNGCQIESGVSISSCRIGDRCRIKAGSVLED
SELRADVAVGPMAHLRPGTVLNDHVKIGNFVETKKTVMGEGSKASHLTYLGDAEIGRDVNIGCGTITCNYDGVKKHRTLI
GDNVFVGSDVQLVAPVRVGADSLIAAGTTVTRDVPAGSLAISRTPQVNREGWRIRMKKKT

Sequences:

>Translated_460_residues
MENVAAIILAAGKGTRMKSGLVKVLHPIAGRPMIDWPLEAARGAGAAPVVLVVGHQAEAVRERFQGAGDIACALQAEQLG
TGHAVACAAPALAGFSGTVLILCGDTPLLRGGTLTDLLAFHRSQGAAVTVLTARMENPHGYGRVLRDEAGRVLRIVEQKD
ASPQECSVREINSGIYCMEAGFLFDNIGSLGNDNAQNEFYLTDLVAMAAQKGATCLAMAIEDSDEIMGVNDRAQLAQAAR
ILRRRINRDLMLSGVSLVDPEQTYIDQGVVIGPDTLIHPNCSISGPTQIGNGCQIESGVSISSCRIGDRCRIKAGSVLED
SELRADVAVGPMAHLRPGTVLNDHVKIGNFVETKKTVMGEGSKASHLTYLGDAEIGRDVNIGCGTITCNYDGVKKHRTLI
GDNVFVGSDVQLVAPVRVGADSLIAAGTTVTRDVPAGSLAISRTPQVNREGWRIRMKKKT
>Mature_460_residues
MENVAAIILAAGKGTRMKSGLVKVLHPIAGRPMIDWPLEAARGAGAAPVVLVVGHQAEAVRERFQGAGDIACALQAEQLG
TGHAVACAAPALAGFSGTVLILCGDTPLLRGGTLTDLLAFHRSQGAAVTVLTARMENPHGYGRVLRDEAGRVLRIVEQKD
ASPQECSVREINSGIYCMEAGFLFDNIGSLGNDNAQNEFYLTDLVAMAAQKGATCLAMAIEDSDEIMGVNDRAQLAQAAR
ILRRRINRDLMLSGVSLVDPEQTYIDQGVVIGPDTLIHPNCSISGPTQIGNGCQIESGVSISSCRIGDRCRIKAGSVLED
SELRADVAVGPMAHLRPGTVLNDHVKIGNFVETKKTVMGEGSKASHLTYLGDAEIGRDVNIGCGTITCNYDGVKKHRTLI
GDNVFVGSDVQLVAPVRVGADSLIAAGTTVTRDVPAGSLAISRTPQVNREGWRIRMKKKT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=46.7105263157895, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI21355443, Length=380, Percent_Identity=27.1052631578947, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24644084, Length=380, Percent_Identity=27.1052631578947, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PELPD (A1ALB2)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900190.1
- ProteinModelPortal:   A1ALB2
- STRING:   A1ALB2
- GeneID:   4572872
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0501
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A1ALB2
- ProtClustDB:   PRK14355
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48577; Mature: 48577

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 366-366 BINDING 75-75 BINDING 142-142 BINDING 157-157 BINDING 172-172 BINDING 390-390 BINDING 408-408 BINDING 426-426 BINDING 443-443

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVAAIILAAGKGTRMKSGLVKVLHPIAGRPMIDWPLEAARGAGAAPVVLVVGHQAEAV
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHH
RERFQGAGDIACALQAEQLGTGHAVACAAPALAGFSGTVLILCGDTPLLRGGTLTDLLAF
HHHHCCCCCEEEEEEHHHCCCCCEEHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
HRSQGAAVTVLTARMENPHGYGRVLRDEAGRVLRIVEQKDASPQECSVREINSGIYCMEA
HCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCCCEEEEEC
GFLFDNIGSLGNDNAQNEFYLTDLVAMAAQKGATCLAMAIEDSDEIMGVNDRAQLAQAAR
CCHHHHHCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHHHHHHHHH
ILRRRINRDLMLSGVSLVDPEQTYIDQGVVIGPDTLIHPNCSISGPTQIGNGCQIESGVS
HHHHHCCCCEEECCCEEECCCHHHHCCCEEECCCCEECCCCCCCCCCCCCCCCEECCCCC
ISSCRIGDRCRIKAGSVLEDSELRADVAVGPMAHLRPGTVLNDHVKIGNFVETKKTVMGE
EEEECCCCEEEEECCCEECCCCCCCEEEECCHHHCCCCCEECCCEECCCHHHHHHHHHCC
GSKASHLTYLGDAEIGRDVNIGCGTITCNYDGVKKHRTLIGDNVFVGSDVQLVAPVRVGA
CCCCCEEEEECCCCCCCEEECCCEEEEECCCCCHHHHHEECCCEEECCCCEEEEEEEECC
DSLIAAGTTVTRDVPAGSLAISRTPQVNREGWRIRMKKKT
CHHEECCCEEECCCCCCCEEEECCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MENVAAIILAAGKGTRMKSGLVKVLHPIAGRPMIDWPLEAARGAGAAPVVLVVGHQAEAV
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHH
RERFQGAGDIACALQAEQLGTGHAVACAAPALAGFSGTVLILCGDTPLLRGGTLTDLLAF
HHHHCCCCCEEEEEEHHHCCCCCEEHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
HRSQGAAVTVLTARMENPHGYGRVLRDEAGRVLRIVEQKDASPQECSVREINSGIYCMEA
HCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCCCEEEEEC
GFLFDNIGSLGNDNAQNEFYLTDLVAMAAQKGATCLAMAIEDSDEIMGVNDRAQLAQAAR
CCHHHHHCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHHHHHHHHH
ILRRRINRDLMLSGVSLVDPEQTYIDQGVVIGPDTLIHPNCSISGPTQIGNGCQIESGVS
HHHHHCCCCEEECCCEEECCCHHHHCCCEEECCCCEECCCCCCCCCCCCCCCCEECCCCC
ISSCRIGDRCRIKAGSVLEDSELRADVAVGPMAHLRPGTVLNDHVKIGNFVETKKTVMGE
EEEECCCCEEEEECCCEECCCCCCCEEEECCHHHCCCCCEECCCEECCCHHHHHHHHHCC
GSKASHLTYLGDAEIGRDVNIGCGTITCNYDGVKKHRTLIGDNVFVGSDVQLVAPVRVGA
CCCCCEEEEECCCCCCCEEECCCEEEEECCCCCHHHHHEECCCEEECCCCEEEEEEEECC
DSLIAAGTTVTRDVPAGSLAISRTPQVNREGWRIRMKKKT
CHHEECCCEEECCCCCCCEEEECCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA