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The map label for this gene is folD

Identifier: 118578919

GI number: 118578919

Start: 502354

End: 503205

Strand: Direct

Name: folD

Synonym: Ppro_0480

Alternate gene names: 118578919

Gene position: 502354-503205 (Clockwise)

Preceding gene: 118578918

Following gene: 118578920

Centisome position: 12.53

GC content: 60.45

Gene sequence:

>852_bases
ATGGCCCACATAATCGACGGCAAAGCGATTGCCGCCAAAATCAGATCGGAAATTGCGTCCGGTGTCCGCGAACTGCAGGG
TAAGGGGGTTACGCCGGGACTGGCGGTGGTGCTGGTGGGAGATGACCAGGCCAGTCGCGTGTATGTCAGCATGAAGGAGA
AGGCCTGCAACGATGCCGGTATTTTTTCCGTCGAGCACAAGCTGGCGGCAGAAACCAGCGAAGCGGAACTGCTGGCTTTG
GTGGAACTGCTCAACAACGATCCGAAAATACATGGAATACTGGTACAGTTGCCGCTGCCTTCCCAGATCGATACGGACAA
GGTTCTGGAGGCCATATCTCCTTTCAAGGATGTTGACGGCTTCCACCCCTACAACGTGGGACGCCTGTCCGTCGGCAAGC
CGGTCTTCCAGCCCTGCACACCCTACGGCGTCATGGTCATGCTTCGCGAAGCCGGGGTGGAGCTGAAGGGCAAGGAGGTG
GTCGTGGTGGGGCGTTCCAATATCGTTGGCAAACCGGTGGCCATGATGTGCCTGGCCGAGCACGCCACGGTGACCCTCTG
TCATTCCCGCACCCGCGACCTTCCCGATGTGGTGCGTCGGGCCGACGTGGTTATCGCGGCGGTCGGTCGGCCGGAGATGA
TCAAGGGGGACTGGATCAAGGAAGGGGCGGTGGTGATCGATGTGGGCATCAACCGCGTGGGAGAGAAGAAGCTGGTGGGC
GATGTGGAATTTGCCGGCGCCAGCCAGAGAGCCAGCGCCATTACGCCGGTTCCGGGAGGAGTCGGGCCCATGACTATCAC
CATGCTGCTCCAGAATACCCTGGAGTCGGCCAAGAGGGGCATGGCGGAATAG

Upstream 100 bases:

>100_bases
TATGGCCCGGCAGGTCTTCTTTTTTGTCGAACGGAACAGTCTTTACAAGACCGGCTTCATGCCGGTATTATTGATACATT
TTTACCCCCAAGGAGATAGT

Downstream 100 bases:

>100_bases
GGCGCGAAGCAGGGAAACAGTAGCTGCCTGTCGTTTGTGTGTCGTGCAATTGCCGAATATTTCATCTGGAGGTCTGCATC
CATGAAGGTCAGAAAAGCCG

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVEHKLAAETSEAELLAL
VELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEV
VVVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVG
DVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE

Sequences:

>Translated_283_residues
MAHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVEHKLAAETSEAELLAL
VELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEV
VVVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVG
DVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE
>Mature_282_residues
AHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVEHKLAAETSEAELLALV
ELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVV
VVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVGD
VEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=290, Percent_Identity=47.5862068965517, Blast_Score=261, Evalue=6e-70,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=44.8630136986301, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI94721354, Length=292, Percent_Identity=46.2328767123288, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI36796743, Length=273, Percent_Identity=26.7399267399267, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786741, Length=277, Percent_Identity=54.8736462093863, Blast_Score=293, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17568735, Length=258, Percent_Identity=45.7364341085271, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319558, Length=291, Percent_Identity=49.1408934707904, Blast_Score=275, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6321643, Length=299, Percent_Identity=46.1538461538462, Blast_Score=261, Evalue=8e-71,
Organism=Drosophila melanogaster, GI62472483, Length=289, Percent_Identity=47.4048442906574, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI45551871, Length=289, Percent_Identity=47.4048442906574, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24645718, Length=289, Percent_Identity=47.4048442906574, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137370, Length=289, Percent_Identity=47.4048442906574, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17136816, Length=295, Percent_Identity=45.0847457627119, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17136818, Length=295, Percent_Identity=45.0847457627119, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PELPD (A1AL91)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900169.1
- ProteinModelPortal:   A1AL91
- SMR:   A1AL91
- STRING:   A1AL91
- GeneID:   4572904
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0480
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- PhylomeDB:   A1AL91
- ProtClustDB:   CLSK828063
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30072; Mature: 29940

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAG
CCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEHHHCCCCCC
IFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDG
EEEEHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCHHHCCC
FHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMCLAE
CCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCEECCCEEEEECCCCCCCCHHHHHHHHC
HATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVG
CCEEEEECCCCCCHHHHHHHHCEEEEECCCCCEECCCEECCCCEEEEECCCCCCCCHHCC
DVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAG
CEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEHHHCCCCCC
IFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDG
EEEEHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCHHHCCC
FHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMCLAE
CCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCEECCCEEEEECCCCCCCCHHHHHHHHC
HATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVG
CCEEEEECCCCCCHHHHHHHHCEEEEECCCCCEECCCEECCCCEEEEECCCCCCCCHHCC
DVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA