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The map label for this gene is atoC [H]

Identifier: 118578820

GI number: 118578820

Start: 391229

End: 392647

Strand: Direct

Name: atoC [H]

Synonym: Ppro_0378

Alternate gene names: 118578820

Gene position: 391229-392647 (Clockwise)

Preceding gene: 118578819

Following gene: 118578821

Centisome position: 9.76

GC content: 63.28

Gene sequence:

>1419_bases
ATGAACGGCCCCTGCGGAAAGATCCTGCTGGTGGATGACGAGCAGAGCATCCTGCTCACCTCGGGCACCCTGCTGCGCAG
TGCCGGCATACGTGACGTGCTGACTCTTGACGATGCCAGAAAGGTGCTTCCTCTGCTTGAACGGGAACGGGTGGACGTGA
TCGTCCTGGACCTGTTCATGCCCTTTGTTTCCGGGAAGGAGTTGCTGGCGGAGATCGCCCAGGAGTATCCCCAGATCCCC
CTGCTGGTCATGACCGCAGCCGATGAGCTGGAAACTGCGGTGGAGTGCATGAAGGCCGGTGCCTTCGACTATCTGGTCAA
GCCGGTGGAACGCTCGCGCTTCATCTCCAGCGTCACCAAGGCCTTGGAGATCTGCAGCCTCAGGAAACAGATGGACGATC
TCCGGGATCACCTGCTGCATGGCAGGTTGGAGCAGCCCTCGGTGTTTTCAGCCATCATCACCGCCAGCGAAAAGATGACC
ACTATCTTCCAGTACGCGGAGGTGGTGGCCCGTTCCAGCGAGCCGATGCTGATCACCGGCGAGACCGGCGTGGGCAAGGA
GTTGGTTGCCAGGGCGGTGCATGATGCCAGCGGACTAAAGGGGAGTTTCGTGCCGGTGAACGTGGCAGCCCTGGATGACG
CACTGTTCTCCGATACACTGTTCGGGCACCGCAAGGGCGCCTTCACCGGCGCAAGCACACCGCGGGAGGGGATGATCGCC
CAGGCCTCCGGCGGTACGCTGCTCCTGGATGAGATCGGGGACCTGAGGCAGCCGTCCCAGGTCAAGCTCCTCAGGCTCTT
GCAGGAGCGGGAGTATTACCCCGTGGGTTCCGATGTCCCCCGCAAGAACAACGCCCGCATCATCGCCGTCACCAACCGCT
CCCTGCGGGACATGGTGGCGGCCGGCGCGTTCCGCAAGGACCTCTACTATCGCCTCTGCGCTCACCATGTGGAGATTCCC
CCCCTGCGCGAGCGGCGGGAAGATCTCCCGCTGCTTCTGGATCACTTCCTGGAGAAGGGCTCCCTGGCCTTGGGCGTAAA
GAAGCCGGCGATTCCCCCCCAGTCGCTTCCGCTGCTGGCCTCCTATTCCTTCCCTGGCAATGTGCGGGAACTGGAGGCCA
TGGTGTGCGATGCAATTGCCCGCCACCGTTCGGGCATGCTCTCCCTGGACAGCTTCAGGCGCTGCATGCGCGAGGGGCAG
GCCATGGGGACACAACCGGGCGCCGAAGCGGCGGCATCCCGGCGGGCGTTGTGGGATCAGTTTTCCGCGCTTCCTTCCCT
CAGGGAGGCGGAGAGCTTTTTGATCAGGGAAGCCCTGAAGCGGTCGGAGGGAAACCAGGGTATCGCCGCGGCGCTTCTGG
GAATCTCCCGCACCGCCCTGAATAAACGGCTGAAACGGGAACCTGGCCTGGTCCCCTGA

Upstream 100 bases:

>100_bases
GCTCCATCGTCAAGAAACATCGCGGCACGCTGGACTGCCAGCCGTCCGCCGAAGGGGGCACGGTTTTCAGCGTCAGGCTG
CCCGCCTCGGGAGCCGTGTG

Downstream 100 bases:

>100_bases
CCCCTGTGCTTTTTTTCACAGCAGGGACAATCGCCACAGCCCCGTCGGTTCCCCTGCCGCCGGCATCGGCGCGGCTCCGT
TCGCCGGCGATGTGCTCTTT

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNGPCGKILLVDDEQSILLTSGTLLRSAGIRDVLTLDDARKVLPLLERERVDVIVLDLFMPFVSGKELLAEIAQEYPQIP
LLVMTAADELETAVECMKAGAFDYLVKPVERSRFISSVTKALEICSLRKQMDDLRDHLLHGRLEQPSVFSAIITASEKMT
TIFQYAEVVARSSEPMLITGETGVGKELVARAVHDASGLKGSFVPVNVAALDDALFSDTLFGHRKGAFTGASTPREGMIA
QASGGTLLLDEIGDLRQPSQVKLLRLLQEREYYPVGSDVPRKNNARIIAVTNRSLRDMVAAGAFRKDLYYRLCAHHVEIP
PLRERREDLPLLLDHFLEKGSLALGVKKPAIPPQSLPLLASYSFPGNVRELEAMVCDAIARHRSGMLSLDSFRRCMREGQ
AMGTQPGAEAAASRRALWDQFSALPSLREAESFLIREALKRSEGNQGIAAALLGISRTALNKRLKREPGLVP

Sequences:

>Translated_472_residues
MNGPCGKILLVDDEQSILLTSGTLLRSAGIRDVLTLDDARKVLPLLERERVDVIVLDLFMPFVSGKELLAEIAQEYPQIP
LLVMTAADELETAVECMKAGAFDYLVKPVERSRFISSVTKALEICSLRKQMDDLRDHLLHGRLEQPSVFSAIITASEKMT
TIFQYAEVVARSSEPMLITGETGVGKELVARAVHDASGLKGSFVPVNVAALDDALFSDTLFGHRKGAFTGASTPREGMIA
QASGGTLLLDEIGDLRQPSQVKLLRLLQEREYYPVGSDVPRKNNARIIAVTNRSLRDMVAAGAFRKDLYYRLCAHHVEIP
PLRERREDLPLLLDHFLEKGSLALGVKKPAIPPQSLPLLASYSFPGNVRELEAMVCDAIARHRSGMLSLDSFRRCMREGQ
AMGTQPGAEAAASRRALWDQFSALPSLREAESFLIREALKRSEGNQGIAAALLGISRTALNKRLKREPGLVP
>Mature_472_residues
MNGPCGKILLVDDEQSILLTSGTLLRSAGIRDVLTLDDARKVLPLLERERVDVIVLDLFMPFVSGKELLAEIAQEYPQIP
LLVMTAADELETAVECMKAGAFDYLVKPVERSRFISSVTKALEICSLRKQMDDLRDHLLHGRLEQPSVFSAIITASEKMT
TIFQYAEVVARSSEPMLITGETGVGKELVARAVHDASGLKGSFVPVNVAALDDALFSDTLFGHRKGAFTGASTPREGMIA
QASGGTLLLDEIGDLRQPSQVKLLRLLQEREYYPVGSDVPRKNNARIIAVTNRSLRDMVAAGAFRKDLYYRLCAHHVEIP
PLRERREDLPLLLDHFLEKGSLALGVKKPAIPPQSLPLLASYSFPGNVRELEAMVCDAIARHRSGMLSLDSFRRCMREGQ
AMGTQPGAEAAASRRALWDQFSALPSLREAESFLIREALKRSEGNQGIAAALLGISRTALNKRLKREPGLVP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=468, Percent_Identity=38.2478632478632, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=37.2093023255814, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=38.0129589632829, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788905, Length=475, Percent_Identity=36.4210526315789, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789087, Length=324, Percent_Identity=41.358024691358, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=41.1214953271028, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87082152, Length=326, Percent_Identity=39.5705521472393, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789233, Length=303, Percent_Identity=37.953795379538, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1786524, Length=398, Percent_Identity=34.6733668341709, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081872, Length=310, Percent_Identity=34.8387096774194, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1787583, Length=236, Percent_Identity=36.4406779661017, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789828, Length=251, Percent_Identity=38.2470119521912, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI87081858, Length=315, Percent_Identity=28.2539682539683, Blast_Score=99, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51863; Mature: 51863

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGPCGKILLVDDEQSILLTSGTLLRSAGIRDVLTLDDARKVLPLLERERVDVIVLDLFM
CCCCCCEEEEEECCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
PFVSGKELLAEIAQEYPQIPLLVMTAADELETAVECMKAGAFDYLVKPVERSRFISSVTK
HHHCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALEICSLRKQMDDLRDHLLHGRLEQPSVFSAIITASEKMTTIFQYAEVVARSSEPMLITG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
ETGVGKELVARAVHDASGLKGSFVPVNVAALDDALFSDTLFGHRKGAFTGASTPREGMIA
CCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
QASGGTLLLDEIGDLRQPSQVKLLRLLQEREYYPVGSDVPRKNNARIIAVTNRSLRDMVA
ECCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
AGAFRKDLYYRLCAHHVEIPPLRERREDLPLLLDHFLEKGSLALGVKKPAIPPQSLPLLA
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEE
SYSFPGNVRELEAMVCDAIARHRSGMLSLDSFRRCMREGQAMGTQPGAEAAASRRALWDQ
ECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FSALPSLREAESFLIREALKRSEGNQGIAAALLGISRTALNKRLKREPGLVP
HHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNGPCGKILLVDDEQSILLTSGTLLRSAGIRDVLTLDDARKVLPLLERERVDVIVLDLFM
CCCCCCEEEEEECCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
PFVSGKELLAEIAQEYPQIPLLVMTAADELETAVECMKAGAFDYLVKPVERSRFISSVTK
HHHCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALEICSLRKQMDDLRDHLLHGRLEQPSVFSAIITASEKMTTIFQYAEVVARSSEPMLITG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
ETGVGKELVARAVHDASGLKGSFVPVNVAALDDALFSDTLFGHRKGAFTGASTPREGMIA
CCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
QASGGTLLLDEIGDLRQPSQVKLLRLLQEREYYPVGSDVPRKNNARIIAVTNRSLRDMVA
ECCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
AGAFRKDLYYRLCAHHVEIPPLRERREDLPLLLDHFLEKGSLALGVKKPAIPPQSLPLLA
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEE
SYSFPGNVRELEAMVCDAIARHRSGMLSLDSFRRCMREGQAMGTQPGAEAAASRRALWDQ
ECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FSALPSLREAESFLIREALKRSEGNQGIAAALLGISRTALNKRLKREPGLVP
HHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]