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The map label for this gene is xseA [H]

Identifier: 118578622

GI number: 118578622

Start: 181105

End: 182685

Strand: Direct

Name: xseA [H]

Synonym: Ppro_0178

Alternate gene names: 118578622

Gene position: 181105-182685 (Clockwise)

Preceding gene: 118578621

Following gene: 118578623

Centisome position: 4.52

GC content: 55.66

Gene sequence:

>1581_bases
ATGGAGAAACGTTTCTTCCCCCTCTCCGCTATCACAAAGCGGATCAATGAACTGCTGGAACCTGCCATCAGCAAGCAGTT
CTGGGTCAAGGCCGAGATATCCACTGGCCGGGAACGAGGAGGAGCTTTTTACTGTGATCTGGTTGAAACGAATGCCGGCG
GGAAAATCGTCGCAAAGATAGCCTGCACCATATGGCAAAGCGAGCTTGCCACCATCAGGAGGGCATTCAAGGCCAAGAAC
ATGGATCTTGTACTCTCCAACGGGACTGTGGTCGGCTTCCTCTGTTCCCTCCAGTTCAGCCCACAGTACGGCCTGTCACT
TCGGGTCATCGATGCTGACCCGTCCATCGCCCTGGGTGAGATGGAGTTAAAAAAACGGGACATCATCGAACGTCTCCAGA
AGGAGGGGATGTTCGAGACGAACAAGGAACTCTCCGTGCCGCTCCTGCCACTGCGTCTCGGCCTGATCACCAGTGCCGGC
AGTGCGGCGTACAATGACTTCATCCAGACCCTCACGGCATCGGGTTACGGCTTCAAGGTCTTCGTGGCCGACGCCATGAT
GCAAGGAGATCAGACGGAGAAGTCGGTCATGCGGGCACTGGACGCCCTCGCCAGACTCGAAGTTGATCTCGTCTCCATCG
TCCGGGGCGGAGGAAGCAAAACCGACCTCTACTTCCTTGACAACGAAGCCATCGCCCGCAGGATCGCCGGATTTGGCAAG
CCGGTCTGGACTGGCATCGGGCATGAGATCGACACCAGCGTCCTCGACTATGTCGCCAACCGCTCTTTCAAAACCCCTAC
CGCTGCGGCAGAGGAATTGGTGGCCCGCTTCATACAAATGCGCCGCCAACTGGACGAAGCAACGAACACCTTGCAAACCG
TGTGGACCTACCGACTAAAACTCGACCGTGATTATCTGACGAGGGCGATGACCGGCATCCGGCAGGGGTCGAGGAAGCTC
CTGGATGTCACCGCATCATTTCTGCGGGAGCAGGCCAAGGAATTACGACTGAAGGTTCAAGAGCGGCTTTCGACCGAGCA
GGTCGTTATTGGGAGGCGCACGGAGAGATTGCGCTCTCTACCTATGGCCATGATCCAAAACCTTGCGGAGCGACTGGCAG
CAAAACGACAGGAACTCAGATCACGGACATATTCCCGGATTTCCCGGTCAGGAGACACCCTGTCCGTGTTGAAGCAACGC
TTTGTGAAGGAACGCTTTCTGCGCCGACTGCTCGTTGAGCGGGACAGCATCATGAAAGTCCGGCAGCAACTGAAGACCCG
GTTCCTCTCCACATTCAGGATTAAGTCGATGACACTCGCTAACCTGAAGGGTCGACTCAAGGAAGAGAGAATTCTCCTGC
GGTTCGGGACGGCCCGCAACAGCCTGAACGACAAGATGGCAATCCTGAAAGCCATTGATCCGCAGACTGTCCTGCAACGC
GGTTTTGCCCTAGTGTATGGTCGAAACGGCGCGCTGATCAGGTCAATCAACGATGTCACAGAGAAAGAAATAATGACTAC
CCGCTTGACTGATGGTTCGCTCATCAGCGAGGTTATCGCAAAGGAGAAACATCATGAGTGA

Upstream 100 bases:

>100_bases
TTGATCAAGTCCAGAAGCAACTGCGCACCGGACAGGCGAAAATAGTCTTCGACCTGGTATCCAAGACCTGTAACATCATT
CCGAGCAGGTGACCGCATCA

Downstream 100 bases:

>100_bases
CACAACAGAGCTTACTTATGAGCAGAAAGTTGAAAAACTGGACGAGATCCTGACTAGGCTCGACAACTCAGAGACCCCCA
TCGACAAACTTGCTGAAGAC

Product: exodeoxyribonuclease VII

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MEKRFFPLSAITKRINELLEPAISKQFWVKAEISTGRERGGAFYCDLVETNAGGKIVAKIACTIWQSELATIRRAFKAKN
MDLVLSNGTVVGFLCSLQFSPQYGLSLRVIDADPSIALGEMELKKRDIIERLQKEGMFETNKELSVPLLPLRLGLITSAG
SAAYNDFIQTLTASGYGFKVFVADAMMQGDQTEKSVMRALDALARLEVDLVSIVRGGGSKTDLYFLDNEAIARRIAGFGK
PVWTGIGHEIDTSVLDYVANRSFKTPTAAAEELVARFIQMRRQLDEATNTLQTVWTYRLKLDRDYLTRAMTGIRQGSRKL
LDVTASFLREQAKELRLKVQERLSTEQVVIGRRTERLRSLPMAMIQNLAERLAAKRQELRSRTYSRISRSGDTLSVLKQR
FVKERFLRRLLVERDSIMKVRQQLKTRFLSTFRIKSMTLANLKGRLKEERILLRFGTARNSLNDKMAILKAIDPQTVLQR
GFALVYGRNGALIRSINDVTEKEIMTTRLTDGSLISEVIAKEKHHE

Sequences:

>Translated_526_residues
MEKRFFPLSAITKRINELLEPAISKQFWVKAEISTGRERGGAFYCDLVETNAGGKIVAKIACTIWQSELATIRRAFKAKN
MDLVLSNGTVVGFLCSLQFSPQYGLSLRVIDADPSIALGEMELKKRDIIERLQKEGMFETNKELSVPLLPLRLGLITSAG
SAAYNDFIQTLTASGYGFKVFVADAMMQGDQTEKSVMRALDALARLEVDLVSIVRGGGSKTDLYFLDNEAIARRIAGFGK
PVWTGIGHEIDTSVLDYVANRSFKTPTAAAEELVARFIQMRRQLDEATNTLQTVWTYRLKLDRDYLTRAMTGIRQGSRKL
LDVTASFLREQAKELRLKVQERLSTEQVVIGRRTERLRSLPMAMIQNLAERLAAKRQELRSRTYSRISRSGDTLSVLKQR
FVKERFLRRLLVERDSIMKVRQQLKTRFLSTFRIKSMTLANLKGRLKEERILLRFGTARNSLNDKMAILKAIDPQTVLQR
GFALVYGRNGALIRSINDVTEKEIMTTRLTDGSLISEVIAKEKHHE
>Mature_526_residues
MEKRFFPLSAITKRINELLEPAISKQFWVKAEISTGRERGGAFYCDLVETNAGGKIVAKIACTIWQSELATIRRAFKAKN
MDLVLSNGTVVGFLCSLQFSPQYGLSLRVIDADPSIALGEMELKKRDIIERLQKEGMFETNKELSVPLLPLRLGLITSAG
SAAYNDFIQTLTASGYGFKVFVADAMMQGDQTEKSVMRALDALARLEVDLVSIVRGGGSKTDLYFLDNEAIARRIAGFGK
PVWTGIGHEIDTSVLDYVANRSFKTPTAAAEELVARFIQMRRQLDEATNTLQTVWTYRLKLDRDYLTRAMTGIRQGSRKL
LDVTASFLREQAKELRLKVQERLSTEQVVIGRRTERLRSLPMAMIQNLAERLAAKRQELRSRTYSRISRSGDTLSVLKQR
FVKERFLRRLLVERDSIMKVRQQLKTRFLSTFRIKSMTLANLKGRLKEERILLRFGTARNSLNDKMAILKAIDPQTVLQR
GFALVYGRNGALIRSINDVTEKEIMTTRLTDGSLISEVIAKEKHHE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=516, Percent_Identity=25.1937984496124, Blast_Score=118, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 59586; Mature: 59586

Theoretical pI: Translated: 10.67; Mature: 10.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRFFPLSAITKRINELLEPAISKQFWVKAEISTGRERGGAFYCDLVETNAGGKIVAKI
CCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHH
ACTIWQSELATIRRAFKAKNMDLVLSNGTVVGFLCSLQFSPQYGLSLRVIDADPSIALGE
HHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEEECCCCEEECH
MELKKRDIIERLQKEGMFETNKELSVPLLPLRLGLITSAGSAAYNDFIQTLTASGYGFKV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
FVADAMMQGDQTEKSVMRALDALARLEVDLVSIVRGGGSKTDLYFLDNEAIARRIAGFGK
EEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCC
PVWTGIGHEIDTSVLDYVANRSFKTPTAAAEELVARFIQMRRQLDEATNTLQTVWTYRLK
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LDRDYLTRAMTGIRQGSRKLLDVTASFLREQAKELRLKVQERLSTEQVVIGRRTERLRSL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
PMAMIQNLAERLAAKRQELRSRTYSRISRSGDTLSVLKQRFVKERFLRRLLVERDSIMKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQLKTRFLSTFRIKSMTLANLKGRLKEERILLRFGTARNSLNDKMAILKAIDPQTVLQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCHHHHHHC
GFALVYGRNGALIRSINDVTEKEIMTTRLTDGSLISEVIAKEKHHE
CCEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKRFFPLSAITKRINELLEPAISKQFWVKAEISTGRERGGAFYCDLVETNAGGKIVAKI
CCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHH
ACTIWQSELATIRRAFKAKNMDLVLSNGTVVGFLCSLQFSPQYGLSLRVIDADPSIALGE
HHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEEECCCCEEECH
MELKKRDIIERLQKEGMFETNKELSVPLLPLRLGLITSAGSAAYNDFIQTLTASGYGFKV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
FVADAMMQGDQTEKSVMRALDALARLEVDLVSIVRGGGSKTDLYFLDNEAIARRIAGFGK
EEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCC
PVWTGIGHEIDTSVLDYVANRSFKTPTAAAEELVARFIQMRRQLDEATNTLQTVWTYRLK
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LDRDYLTRAMTGIRQGSRKLLDVTASFLREQAKELRLKVQERLSTEQVVIGRRTERLRSL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
PMAMIQNLAERLAAKRQELRSRTYSRISRSGDTLSVLKQRFVKERFLRRLLVERDSIMKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQLKTRFLSTFRIKSMTLANLKGRLKEERILLRFGTARNSLNDKMAILKAIDPQTVLQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCHHHHHHC
GFALVYGRNGALIRSINDVTEKEIMTTRLTDGSLISEVIAKEKHHE
CCEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA