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The map label for this gene is macA [H]

Identifier: 118578589

GI number: 118578589

Start: 154372

End: 155523

Strand: Direct

Name: macA [H]

Synonym: Ppro_0145

Alternate gene names: 118578589

Gene position: 154372-155523 (Clockwise)

Preceding gene: 118578588

Following gene: 118578590

Centisome position: 3.85

GC content: 60.07

Gene sequence:

>1152_bases
ATGAAATCACTGCCAATGCCCGGTCGCACGCTTGCACTGGCTGCGGTCATCATTCCGCTGCTGGCGCTCTTCATCTACGT
CGGCTTTCGTTCCGGACCGCTTGCTCCGGTTTCGGTAACTACCGCAACAGTGACAAAGCGCACAATAACGCCGGCGCTGT
ACGGCATCGGTACCGTTGAGGCACGCTACAGCTTCAAAATCGGCCCAACCTTTGCCGGGCGGATCAAACAGATTAATGTG
AATGTCGGTGACCATGTCACCGCAGGGCAGCTCCTCGGTGAGATGGATCCGGTTGACCTTGATGACCGGGTACGTTCACT
GGAATCGACATTCAACCGGGCGACAGCGGCGCTGCGGGAAGCGGAGGCCCGTCATGCATATGCTCTGAAGCAGGCGAAGC
GCTATGAGGGGCTGCTGGCATCCGGCGCAGTCAGCGAAGAAATCGTCGCAACAAAACTTCAGGAACTGCAGGTGGCGGAT
GCAGCCCTGAGCGCTGCCAGAGAGGATACGGCACGGGTGCGTTCAGACCGGGAAGCGCTGGTGGCGCAGAGAAACAATGT
GCGACTCGTCTCCCCGAAGGGGGGGATTGTCGCCAGGCGCGATGCGGAACCAGGAAGCACCGTCGTTGCCGGACAGACCG
TAGTGGAGATCGTTGACCCGGATACGCTCTGGGTCAACGCCCGTTTTGATCAGACAAGCGCATCCGGGCTTTCCGGCGGC
CTGCCTGCCCGCATCGTGCTTCGTTCCCGTGAGGGTGTGGTGCTGAAGGGGCGCGTGCTGCGCATTGAACCGAAGGCGGA
TTCAGTAACCGAGGAGATGCTGGCGAAGATCAGCTTTGATTCATTTCCGAAACCGCTGCCGCCGCTTGGTGAACTGGCGG
AGGTGACCATCGATCTGCCGCCGGTTGCTCCGGCGCCTGTGGTGCCCAATGCCGCCATCAGGCGATTGGGCGATCAGACA
GGTGTGTGGCGCATTACCGGAAAAGCCATGAGCTTTGTGCCGATCAAACAGGGGCAATCCGATTTGAGCGGCGCTGTGCA
GGTGCGCGAAGGTCTAAACACCGATGATCTGGTGGTACTCTACAGCGAGAAAGCGCTGACGCCGCGCAGTCGCTTCCGTA
TCGTTGAGCGTATCCCGGGAGTGCCGAAATGA

Upstream 100 bases:

>100_bases
GACTGGTCATGCAATCTATGATCTCCGGGGACATGGAACAGATGCGCGGCGAAGCTCCGCACCTGTTTGCCCTGTACCGG
CGCGGAATCAGGAGCGCCGT

Downstream 100 bases:

>100_bases
TCAGCCTGGCCGGCCGTGACATCCTTCACGCCTGGGGGAAATTTGTTTTCACCGGCATCGGTCTCGGACTGCTGATCGGC
GTGACGCTCACCATGGCGGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKSLPMPGRTLALAAVIIPLLALFIYVGFRSGPLAPVSVTTATVTKRTITPALYGIGTVEARYSFKIGPTFAGRIKQINV
NVGDHVTAGQLLGEMDPVDLDDRVRSLESTFNRATAALREAEARHAYALKQAKRYEGLLASGAVSEEIVATKLQELQVAD
AALSAAREDTARVRSDREALVAQRNNVRLVSPKGGIVARRDAEPGSTVVAGQTVVEIVDPDTLWVNARFDQTSASGLSGG
LPARIVLRSREGVVLKGRVLRIEPKADSVTEEMLAKISFDSFPKPLPPLGELAEVTIDLPPVAPAPVVPNAAIRRLGDQT
GVWRITGKAMSFVPIKQGQSDLSGAVQVREGLNTDDLVVLYSEKALTPRSRFRIVERIPGVPK

Sequences:

>Translated_383_residues
MKSLPMPGRTLALAAVIIPLLALFIYVGFRSGPLAPVSVTTATVTKRTITPALYGIGTVEARYSFKIGPTFAGRIKQINV
NVGDHVTAGQLLGEMDPVDLDDRVRSLESTFNRATAALREAEARHAYALKQAKRYEGLLASGAVSEEIVATKLQELQVAD
AALSAAREDTARVRSDREALVAQRNNVRLVSPKGGIVARRDAEPGSTVVAGQTVVEIVDPDTLWVNARFDQTSASGLSGG
LPARIVLRSREGVVLKGRVLRIEPKADSVTEEMLAKISFDSFPKPLPPLGELAEVTIDLPPVAPAPVVPNAAIRRLGDQT
GVWRITGKAMSFVPIKQGQSDLSGAVQVREGLNTDDLVVLYSEKALTPRSRFRIVERIPGVPK
>Mature_383_residues
MKSLPMPGRTLALAAVIIPLLALFIYVGFRSGPLAPVSVTTATVTKRTITPALYGIGTVEARYSFKIGPTFAGRIKQINV
NVGDHVTAGQLLGEMDPVDLDDRVRSLESTFNRATAALREAEARHAYALKQAKRYEGLLASGAVSEEIVATKLQELQVAD
AALSAAREDTARVRSDREALVAQRNNVRLVSPKGGIVARRDAEPGSTVVAGQTVVEIVDPDTLWVNARFDQTSASGLSGG
LPARIVLRSREGVVLKGRVLRIEPKADSVTEEMLAKISFDSFPKPLPPLGELAEVTIDLPPVAPAPVVPNAAIRRLGDQT
GVWRITGKAMSFVPIKQGQSDLSGAVQVREGLNTDDLVVLYSEKALTPRSRFRIVERIPGVPK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=320, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082036, Length=362, Percent_Identity=25.1381215469613, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41076; Mature: 41076

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLPMPGRTLALAAVIIPLLALFIYVGFRSGPLAPVSVTTATVTKRTITPALYGIGTVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCHHHHCCCEEE
ARYSFKIGPTFAGRIKQINVNVGDHVTAGQLLGEMDPVDLDDRVRSLESTFNRATAALRE
EEEEEEECCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEARHAYALKQAKRYEGLLASGAVSEEIVATKLQELQVADAALSAAREDTARVRSDREAL
HHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQRNNVRLVSPKGGIVARRDAEPGSTVVAGQTVVEIVDPDTLWVNARFDQTSASGLSGG
HHCCCCEEEECCCCCEEEECCCCCCCEEEECCEEEEEECCCEEEEEEEECCCCCCCCCCC
LPARIVLRSREGVVLKGRVLRIEPKADSVTEEMLAKISFDSFPKPLPPLGELAEVTIDLP
CCEEEEEECCCCEEEECEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECC
PVAPAPVVPNAAIRRLGDQTGVWRITGKAMSFVPIKQGQSDLSGAVQVREGLNTDDLVVL
CCCCCCCCCHHHHHHCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEE
YSEKALTPRSRFRIVERIPGVPK
ECCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSLPMPGRTLALAAVIIPLLALFIYVGFRSGPLAPVSVTTATVTKRTITPALYGIGTVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCHHHHCCCEEE
ARYSFKIGPTFAGRIKQINVNVGDHVTAGQLLGEMDPVDLDDRVRSLESTFNRATAALRE
EEEEEEECCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEARHAYALKQAKRYEGLLASGAVSEEIVATKLQELQVADAALSAAREDTARVRSDREAL
HHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQRNNVRLVSPKGGIVARRDAEPGSTVVAGQTVVEIVDPDTLWVNARFDQTSASGLSGG
HHCCCCEEEECCCCCEEEECCCCCCCEEEECCEEEEEECCCEEEEEEEECCCCCCCCCCC
LPARIVLRSREGVVLKGRVLRIEPKADSVTEEMLAKISFDSFPKPLPPLGELAEVTIDLP
CCEEEEEECCCCEEEECEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECC
PVAPAPVVPNAAIRRLGDQTGVWRITGKAMSFVPIKQGQSDLSGAVQVREGLNTDDLVVL
CCCCCCCCCHHHHHHCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEE
YSEKALTPRSRFRIVERIPGVPK
ECCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]