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The map label for this gene is menA [H]

Identifier: 118479977

GI number: 118479977

Start: 4646394

End: 4647413

Strand: Direct

Name: menA [H]

Synonym: BALH_4423

Alternate gene names: 118479977

Gene position: 4646394-4647413 (Clockwise)

Preceding gene: 118479961

Following gene: 118479978

Centisome position: 88.38

GC content: 40.69

Gene sequence:

>1020_bases
TTGACACTAAATGATGCTTTTTCTACACTTAGTTGTGTACAATATGTGACCAAAGGAGGATTCAACATGGAAATGAACGT
CGAAACGAATTCCTCTCCTACGGCGCCAAAGCCAAGTAAGCAAACAGGCTGGCGCATTTGGTGGAGTTTACTACGTCCCC
ATACATTAACAGCAGCTTTCGTTCCTGTTTTCATCGGAACAGCCTATGCAATGCAGGTCGGAGGTATAAATCAAATACAT
CTCCCTCTTTTCCTTATAATGCTTCTTGCTTGTCTTCTCATTCAGGCAGCAACAAACATGTTTAATGAATACTTTGATTA
TAAAAGAGGACTCGATCACGAAGGTTCAGTTGGCATCGGCGGCGCTATCGTTCGCGATGGCATTCAGCCAAAAACAGTGC
TTAACTTAGCATTTGGATTTTTCGGTATCGCAATACTATTAGGTGTTTATATTTGTATGAATTCTAGCTGGTGGCTGGCT
GCAATCGGTCTTGTTTGCATGGCCGTTGCTTACCTTTATACAGGCGGTCCACTTCCAATTGCCTATACACCATTTGGAGA
GTTAACAGCCGGATTATTTATGGGTGTCATTATTATCGGGATTTCATTCTTTATTCAAACTGGAACTGTAACATCAGAAG
TCGTTTTACTATCTATTCCAAGCTCCATTTTAATTGGTGCCATTTTACTAGCTAATAACATCCGTGACTTAGATGGCGAT
AAAGAAAATGGTCGTAAAACGTTAGCCATTCTCGTTGGACGTGAGCGAGCAGTTGGTGTACTTGCTTCTATGTTCATCGT
TTCCTACATTTGGACAATTGCTTTAATTATCGTGGGCATCGTATCACCATGGATGCTTATCGTATTTTTAAGTGCACCGA
AAGCATTTAAAGCGACGAAAGGCTTTATCGGCAAAAGCATTCCAATGGAAATGGTACCTGCGATGATAGCAACAGCAAAA
ACAAATACAATCTTCGGTCTCCTTATGGGAATCGGATTATTACTTGGATATTTCCTTTAA

Upstream 100 bases:

>100_bases
AGTCATAATTACGCTTGATTTTAAGATACACCTCAAACGAAAGGCCTGTCAACGTTTAGCATTTCTGAGAAATTCACCTT
CTCTTCCTAGAAAATAAACG

Downstream 100 bases:

>100_bases
AAGGAGCCGCTAATGCGGCTCCTTTTTCATATACCAATTTCAGCTCATAATTCCTACTCGCAACGCTCATACTATGTAAA
GAAACTGAATTGTAGGAAGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTLNDAFSTLSCVQYVTKGGFNMEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIH
LPLFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLA
AIGLVCMAVAYLYTGGPLPIAYTPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGD
KENGRKTLAILVGRERAVGVLASMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAK
TNTIFGLLMGIGLLLGYFL

Sequences:

>Translated_339_residues
MTLNDAFSTLSCVQYVTKGGFNMEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIH
LPLFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLA
AIGLVCMAVAYLYTGGPLPIAYTPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGD
KENGRKTLAILVGRERAVGVLASMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAK
TNTIFGLLMGIGLLLGYFL
>Mature_338_residues
TLNDAFSTLSCVQYVTKGGFNMEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHL
PLFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAA
IGLVCMAVAYLYTGGPLPIAYTPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDK
ENGRKTLAILVGRERAVGVLASMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKT
NTIFGLLMGIGLLLGYFL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=320, Percent_Identity=26.875, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1790365, Length=309, Percent_Identity=25.5663430420712, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737429, Length=281, Percent_Identity=30.2491103202847, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 36596; Mature: 36465

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNDAFSTLSCVQYVTKGGFNMEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAF
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
VPVFIGTAYAMQVGGINQIHLPLFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCE
AYTPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGD
EECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEEEECCHHHHHHHHHHHCCCCCCCCC
KENGRKTLAILVGRERAVGVLASMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATK
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GFIGKSIPMEMVPAMIATAKTNTIFGLLMGIGLLLGYFL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TLNDAFSTLSCVQYVTKGGFNMEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAF
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
VPVFIGTAYAMQVGGINQIHLPLFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCE
AYTPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGD
EECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEEEECCHHHHHHHHHHHCCCCCCCCC
KENGRKTLAILVGRERAVGVLASMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATK
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GFIGKSIPMEMVPAMIATAKTNTIFGLLMGIGLLLGYFL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]