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The map label for this gene is vanSB [H]

Identifier: 118479939

GI number: 118479939

Start: 4601976

End: 4603829

Strand: Reverse

Name: vanSB [H]

Synonym: BALH_4384

Alternate gene names: 118479939

Gene position: 4603829-4601976 (Counterclockwise)

Preceding gene: 118479940

Following gene: 118479937

Centisome position: 87.57

GC content: 31.93

Gene sequence:

>1854_bases
ATGAAAAAAGGGATTGTACTAAAATTATTTACCCTCACAACAGCGCTATGTATGTTAATTTTAGCGACGATTTTTATTGG
ACAAACGATATTTTTTAAACAATATTATGCGAATCGAAAAGTGGAAGACATTAAAGTGAATTTAAATTCCTTTGAGAAGA
ATTATTTAAACTATGCAGGAAATACAGAAGAAATTAAGCGACTGGAGCAAGACTTTTTAAGAGAAAATAATACGTGGATT
ACGACATTAGATCAGAACGGGAATTTAAAGCATGCGGATGATTTTTATTTTGAGGTTACGATAGATCGTAAGCAACAGAA
GAGTTTTGGACAACAAATATTCAACATTCCTTTATACAATCTCATCAATATAGAAGAGATTGATAATAAATCATCCAATC
CGTTTTTAGGGCAAGAAATTTATTTTTCTGGAGTGAAAAAAGAAGAAAGTTTTATTCCATTCTCTTTTTCGTTAGGTAAG
CAAAATTTGAATGGATCTAATAAACCGTTAGAAAAAGCATTTAATGAGAAAATGAGTAAATTAGATCAGGAGAAAAAGAA
AGCAGCTGAGGAACAATTTGGTAAGGAAAAGAAGCCGGTAGTTCAGGAGCAAGCTGCCCAAGAACCAGATGTTCACATAA
GAGGGCGTGTTACGAAAGTTCAGCTTCCGGATGTAACAGGTCCTATAAATCAAATTTATAAAAATAGCATCTTTTTAGAT
AACATAAAAGAATTTCAAACGGATTTATTATTAAAAGAGAGCAAGCACATACAGTATGCAACACAAACAATGGACTATGA
AAAAAATGATATTAAATATAAATTATTAATCAAGCCAATAAAAGAAAAAGATGGATCAGTAACTTATATTTATGCGATGG
CTTCTTTACAGCCTGTAGATGAAGCTGTACAAATGGTGCAAGATTACTACATTTACATCATTGCATTTGTAGTCGTTCTT
ATTTTTCTCGCTGCATTTTATTATTCAAAACAAATTGCAAAACCGTTATTAAAAATAAATGATACGACGAAGAAAATAGC
GCATTTAGATTTCACAGAACAAATACCGATTACTTCAAAAGATGAAATTGGTGATTTATCGAAAAATATTAATACACTCT
CTAACAAATTAAATTCCCATATTGGACAGCTAGAACAAGATATTGAAAAGGAAAGAAAGTTAGAAAAGACGCGGAAAGAA
TTCATTTCTGGTGTTTCGCATGAACTAAAAACACCGCTGAGTATTATGAAAAGCTGTATTTCTATTTTAAAAGATGGAGT
AGCTGAGCATAAAAAAGATTACTATTTTCAAGCGATGGAACGGGAAGTAGACAAAATGGATACGTTAATTTTGGATATGC
TGGAGTTAGCTAAATTTGAGTCAGGCACATATAAAATGAAAAAGGACCCATTTTATATTGATACAGTAATAGAAGATATA
TGTGAACATCTTTCTGTAGAAATAGAGAAAAAAGAACTTCGTGTTCATAAACATTTAGGTCCATTTGAAGTAGTCGCAAA
TCAAGGCCGGATTGAACAAGTCATCGTGAACTTCATTACGAATGCGATACGTTATACACCAAATAAAGAAGATATTATTA
TTTCTACAATAGATGAGAAGGATCGTATAAAAGTATGTATTGAAAATAAAGGTACTCACATTGAAGAAGAGCAATTAGAT
AAAATTTGGGATCGTTTTTATCGCGTAGATGCAGCTCGCCAGCGTTCGCAAGGAGGAACAGGTCTTGGGCTTGCCATTTC
AAAGAATATTTTAGAACTACATGATGCTGAATATGGAGCAGAAAATACAGAAGATGGTGTGTTATTTTATTTCTATTTAC
CGAAAAAAGCGTAG

Upstream 100 bases:

>100_bases
CAGTTAATAGTCATATTCGTAATTTAAGAAATAAATTAGGAGAGAAAGCAAAGTACATTACAACTGTAGTACGAACGGGT
TATAAATTTGAGGGGAATGT

Downstream 100 bases:

>100_bases
ACAATGTGATCTACGCTTTTTTTTTATTTATTTTCATATTATCTTTACCTAATCTTTATTTTTAATCAGTATAATTTGTT
TAGAAAATGAGGTTATGTAA

Product: sensory histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFNIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHLGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Sequences:

>Translated_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFNIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHLGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA
>Mature_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFNIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHLGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=27.1777003484321, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.3898305084746, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=327, Percent_Identity=24.4648318042813, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=23.8235294117647, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=27.8225806451613, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1787894, Length=335, Percent_Identity=22.3880597014925, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=25.9911894273128, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=202, Percent_Identity=25.2475247524752, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=25.5506607929515, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=232, Percent_Identity=24.1379310344828, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788279, Length=327, Percent_Identity=25.3822629969419, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=26.271186440678, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=23.9864864864865, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=20.3174603174603, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=25.1101321585903, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=313, Percent_Identity=21.405750798722, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71488; Mature: 71488

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFNIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
EECHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCHHHH
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDGSVTYIYAMASLQPVD
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHLGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFNIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
EECHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCHHHH
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDGSVTYIYAMASLQPVD
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHLGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]