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The map label for this gene is murC

Identifier: 118479825

GI number: 118479825

Start: 4484132

End: 4485442

Strand: Reverse

Name: murC

Synonym: BALH_4262

Alternate gene names: 118479825

Gene position: 4485442-4484132 (Counterclockwise)

Preceding gene: 118479826

Following gene: 118479824

Centisome position: 85.32

GC content: 37.99

Gene sequence:

>1311_bases
ATGACAGTTTACCATTTTGTAGGAATTAAAGGAACAGGAATGAGTTCATTAGCGCAAATTCTTCATGACATGAAGCATAC
TGTTCAAGGGTCTGATTATGAAAAGCGTTTCTTTACACAAACAGCGTTGGAAAAGCGCAATATCTCGATTCTTCCTTTTG
ATAAAAGTAATGTAAAAGAAGGACAAGTGATTATTGCAGGAAATGCATTTCCTGATACGCATGAAGAAATCGTAGCAGCA
AAAGAATTAAACATCCCAGTACATCGTTACCATCACTTCTTAGGTGACCTTATGAATCAATACACAAGTGTTGCTGTAAC
TGGTGCACATGGAAAAACATCAACAACTGGTTTGTTAGCCCATGTAATGCAAGGTGCACACCCTACATCTTACCTTATTG
GAGATGGAACGGGGCATGGGGTAGAAAATAGTAAGTATTTTGTATTTGAAGCTTGTGAGTATCGTCGTCATTTCTTGTCT
TACAATCCGGACTATGCAATTATGACAAACATTGATTTTGATCATCCAGATTATTTCACAGATATCAATGATGTATTCAG
TGCATTCCAAGAGATGGCATTGCAAGTGAAAAAAGGCATTATTGCATGTGGAGATGATGAAGAACTTCAAAAAATTCAAG
CGAAAGTACCTGTTATTTTCTATGGATTTGGAGAGGATAATGATTTCCAAGCACGTAACATTCAAAAGAGAACTGACGGT
ACTATTTTCGATGTATTCGTTCGTAATACGTACTATGACACGTTCAAAATTACAGGCTACGGCAACCACAGCGTATTAAA
TGCATTAGCAGTAATCGCACTTTGCCATTATGAAAACGTTGATGTAGAAGCAGTTAAGCATCAGCTAACAACTTTTGAAG
GCGTAAAACGTCGCTTTAATGAAAAGCCAATGGGAGAGCAAGTTATTATTGATGACTATGCACACCATCCGACAGAAATT
AATGCAACGATTGAAGCAGCTCGTCAAAAACATCCAGAGCGTGAAATTGTCGCTGTATTCCAGCCACACACATTCTCACG
TACAGAAAAGTTCTTAGATGAATTCGCTGAAAGCCTAAGCAAAGCTGACCAAGTATACTTATGTGATATTTTCGGATCAG
CGCGCGAAAACAAAGGTGAATTAACAATCGAAGATCTGCAAAAGCGTATTGACGGTGCAGAATTAATTACAGATACAACA
ACGGATGTATTAAAGAAACATAAAAACGGCGTTCTCATTTTCATGGGCGCAGGAGACATCCAAAAATTCGAAGCAGCTTA
CGTAAAAGAAGTTCAAGTTGCAGAGAAGTAA

Upstream 100 bases:

>100_bases
ACATCAAAAATGTATGATGATTACCAAAATAAGAAAAGATTCATATACTGTCTTATAGATAGGCCGTTGTATTAGTTCGA
AATGTTGGAGGTTCTTTAAG

Downstream 100 bases:

>100_bases
TAGAAAAGACGCATAGCAGTGGCTGTGCGTCTTTTTTTGTTGTGTTGTAGGGTGTAGTAATGTTGTCGAATTTAGTCGGT
AAGTCGATATCCTTTGACGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAA
KELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLS
YNPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEI
NATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTT
TDVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK

Sequences:

>Translated_436_residues
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAA
KELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLS
YNPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEI
NATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTT
TDVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK
>Mature_435_residues
TVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAAK
ELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSY
NPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDGT
IFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEIN
ATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTT
DVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=29.3617021276596, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790680, Length=385, Percent_Identity=29.8701298701299, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BACAA (C3PBF0)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868966.1
- ProteinModelPortal:   C3PBF0
- SMR:   C3PBF0
- EnsemblBacteria:   EBBACT00000125716
- GeneID:   7849747
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4948
- GeneTree:   EBGT00050000000630
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49257; Mature: 49126

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKE
CEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
GQVIIAGNAFPDTHEEIVAAKELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSYNPDYAIMTNIDFDHPDYFT
HHHHCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHC
DINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
CHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHCCC
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFN
CEEEEEEECCEECEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
EKPMGEQVIIDDYAHHPTEINATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTTDVLKKHKNGVLIFMGAGDI
CCCEEEEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECCCH
QKFEAAYVKEVQVAEK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKE
EEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
GQVIIAGNAFPDTHEEIVAAKELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSYNPDYAIMTNIDFDHPDYFT
HHHHCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHC
DINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
CHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHCCC
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFN
CEEEEEEECCEECEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
EKPMGEQVIIDDYAHHPTEINATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTTDVLKKHKNGVLIFMGAGDI
CCCEEEEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECCCH
QKFEAAYVKEVQVAEK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA