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The map label for this gene is megL [H]

Identifier: 118479795

GI number: 118479795

Start: 4456813

End: 4457991

Strand: Reverse

Name: megL [H]

Synonym: BALH_4232

Alternate gene names: 118479795

Gene position: 4457991-4456813 (Counterclockwise)

Preceding gene: 118479798

Following gene: 118479793

Centisome position: 84.8

GC content: 39.27

Gene sequence:

>1179_bases
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACATCAGAGGAACATAAAGGAAGTTTAACACCGCC
TTTATTTCAAACGTCTACATTTACATTTGAGACTGCGCAGCAAGGAGAGGCGAGTTTTGCGGGAGTGGATCCATCTTATA
TTTACTCAAGACTTGGAAATCCGACTGTGAAACTATTTGAAGAACGTATGGAAGTGTTAGAAGGTGGAGAAGAAGCTCTT
GCTTTCGGATCCGGAATGGCAGCTATTTCAGCAACTTTAATTGGTTTTCTAAAAGCTGGAGATCATATTATTTGTTCAAA
TGGATTATACGGATGCACGTACGGTTTTTTAGAGGTGTTAGAAGAAAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGGGTGATATTGAAAATAAAATTCGCCCAAATACAAAGCTTATTTTCGTTGAAACACCAATTAATCCGACAATG
AAACTAATTGATTTAAAACAAGTGATTCGGGTTGCGAAGCGAAATGGGTTACTTGTCATTGTTGATAATACGTTTTGTTC
ACCTTATTTACAAAGACCGCTTGAACTTGGCTGTGACGCCGTTGTTCATAGTGCGACAAAATATATTGGTGGTCACGGTG
ATGTTGTGGCGGGTGTAACAATTTGTAAAACGAGAGCGTTAGCTGAAAAAATCCGCCCGATGCGAAAAGATATCGGCGGT
ATTATGGCGCCGTTTGATGCGTGGTTATTGTTACGCGGATTAAAGACACTAGCGGTAAGGATGGACCGCCATTGTGATAA
TGCAGAAAAAATTGTATCGTTTCTAAAAAATCATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGGGAGTTAGCATCTC
GCCAAATGAAACGGGGCGGTGGCGTTATATCTTTTTCAATTAAAGGCGGGAAAGAAGAGACGCAGGCGTTTATTAATGAC
CTTCACTTTATTACAATTGCAGTAAGTTTAGGAGATACAGAAACGTTAATTCAGCACCCGGCAACGATGACGCACGCTGC
GATTCCAGCTGAGTTAAGACAAGAAATGGGTATTTATGATAATTTAATACGTTTATCTGTCGGTTTAGAATCGTGGGAGG
ATATCGTTTCTGATTTAGAGCAAGCATTAAAGAAAATATCTACTGTTAGTAATCAATAA

Upstream 100 bases:

>100_bases
TAGAAACACAAATAAAACGCTTACATAAAATGAAGTAAAACGTTCATCAAATTTTTAATGATGAATATGCGGCAATAAAA
ACATAAAAGGGGATGTTTTT

Downstream 100 bases:

>100_bases
AAAAAGAGCTAGCTATCGGTTTTGTACGCAATGTACTCAATCGATAACTAGCTCTTTTTTGTTACATATGTTTTAGGAGT
GTTTCCACAAACTTTTCTAA

Product: methionine gamma-lyase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMEVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEGDIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

Sequences:

>Translated_392_residues
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMEVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEGDIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ
>Mature_392_residues
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMEVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEGDIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=389, Percent_Identity=40.3598971722365, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI299473759, Length=389, Percent_Identity=35.9897172236504, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI25453487, Length=388, Percent_Identity=35.3092783505155, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1790375, Length=390, Percent_Identity=36.1538461538462, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789383, Length=397, Percent_Identity=27.455919395466, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=390, Percent_Identity=40, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538055, Length=390, Percent_Identity=41.025641025641, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=39.4594594594595, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI193202265, Length=88, Percent_Identity=37.5, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319307, Length=391, Percent_Identity=38.8746803069054, Blast_Score=265, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6323333, Length=446, Percent_Identity=30.0448430493274, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6321254, Length=413, Percent_Identity=30.2663438256659, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=400, Percent_Identity=30.5, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=320, Percent_Identity=30.3125, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19922554, Length=385, Percent_Identity=37.9220779220779, Blast_Score=260, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 43296; Mature: 43296

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGN
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCC
PTVKLFEERMEVLEGGEEALAFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVL
HHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
EEKFMITHSFCDMETEGDIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVI
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEE
VDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
ECCCCCCHHHHCHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCC
GVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYD
CEEEEEECCCHHHHHHHHHCCEEEEEEEECCCHHHHHHCCCHHHHHHCCHHHHHHCCHHH
NLIRLSVGLESWEDIVSDLEQALKKISTVSNQ
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGN
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCC
PTVKLFEERMEVLEGGEEALAFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVL
HHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
EEKFMITHSFCDMETEGDIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVI
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEE
VDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
ECCCCCCHHHHCHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCC
GVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYD
CEEEEEECCCHHHHHHHHHCCEEEEEEEECCCHHHHHHCCCHHHHHHCCHHHHHHCCHHH
NLIRLSVGLESWEDIVSDLEQALKKISTVSNQ
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]