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The map label for this gene is mdh [H]

Identifier: 118479749

GI number: 118479749

Start: 4409349

End: 4410653

Strand: Reverse

Name: mdh [H]

Synonym: BALH_4186

Alternate gene names: 118479749

Gene position: 4410653-4409349 (Counterclockwise)

Preceding gene: 118479750

Following gene: 118479748

Centisome position: 83.9

GC content: 40.46

Gene sequence:

>1305_bases
GTGTTCGTGGTCAGACCACTTGGAGAAATTGATATCAGCAAGAATAATTTGAGGAGAGTGGATAGTTTGTCAACACTTCG
TGAAGAAGCACTTCACATGCATAAAGTGCATCAAGGAAAATTAGAAACTGTATCAAAAGTAAAAGTAGAAAATGCAAAAG
ATTTAAGTCTTGCATATTCTCCAGGGGTTGCAGAACCTTGTAAGGAAATTTATGACGATAAAAGTAAGGTATATGAATAT
ACAATGAAGGGAAATATGGTAGCAGTTGTGACAGATGGAACGGCTGTACTTGGTCTTGGTAACATTGGACCAGAAGCATC
TCTTCCAGTAATGGAAGGTAAAGCTGTATTATTTAAGAGCTTTGCTGGTGTAGATGCATTCCCAATTGCCTTAAATACAA
ACGATGTAGATAAAATTGTTGAAACTGTAAAATTAATGGAGCCAACTTTTGGCGGCGTTAACTTAGAGGATATCGCAGCA
CCAAACTGCTTCATTATTGAAGAACGTTTGAAAAAAGAAACAAATATTCCTATCTTCCATGATGATCAACACGGAACAGC
TATCGTAACAGTAGCAGGTCTTGTGAACGCGCTAAAACTAGTTGGAAAGAAAATGTCTGACATTAAAGTTGTCGCAAATG
GCGCAGGTGCAGCAGGTATTGCAATTATTAAACTTTTATATCGCTATGGCGTACGCGACATTATTATGTGTGACCGTAAA
GGCGCGATCTATGAAGGTCGTCCTACAGGTATGAATCCGGTGAAGGATGAAGTTGCAAAATATACAAATAAGAATCGTAT
CGAAGGTTCTTTAGCTGATGTTGTACAAGGTGCGGACGTATTCATTGGTGTATCTGCAGAAGGTGCATTAACAGAAGAGA
TGGTTCGTACAATGAATGACAATGCAATTATTTTTGCAATGGCGAATCCAGTTCCAGAAATTATGCCAGAATTGGCAAAA
GCAGCGGGCGCAGCTGTTGTTGGAACAGGTCGTTCTGACTTTGCAAACCAAGTAAATAATGTACTGGCGTTCCCTGGTAT
TTTCCGCGGTGCACTTGACGTACATGCGACACAAATTAACGAAGAAATGAAGATGGCAGCTGTACAAGCCATTGCTGAGC
TTGTAGCAGAAGATGAGTTAAATGCAGACTATATCATTCCAGCACCGTTTGATGCGCGTGTAGCGCCTCAAGTAGCAGCT
TACGTTGCGAAAGCTGCAATGGAGACAGGAGTAGCTCGCCGTCAAGTGGATCCAAATGAAGTTGCTGAGAAAACAAAACA
ATTAGCGCTGATTGGTAAAGAATAA

Upstream 100 bases:

>100_bases
GAAGAATGTTTAGGAGCACTTCGTGAAATTGTCGGGGAAGAAAATGTGGTTTTGAAAATATAATGGACAATTTCCCTACA
CTTCGATTATTATAGTAGTA

Downstream 100 bases:

>100_bases
GCGAGGAATTTCCATTGACATCATCAAATACAAAAGTATATCTCGAAATTGTAAAAAAAATCCGTTCCATTATGGAAGAG
GATGGATTGGTAGCAGGGGA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 4 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MFVVRPLGEIDISKNNLRRVDSLSTLREEALHMHKVHQGKLETVSKVKVENAKDLSLAYSPGVAEPCKEIYDDKSKVYEY
TMKGNMVAVVTDGTAVLGLGNIGPEASLPVMEGKAVLFKSFAGVDAFPIALNTNDVDKIVETVKLMEPTFGGVNLEDIAA
PNCFIIEERLKKETNIPIFHDDQHGTAIVTVAGLVNALKLVGKKMSDIKVVANGAGAAGIAIIKLLYRYGVRDIIMCDRK
GAIYEGRPTGMNPVKDEVAKYTNKNRIEGSLADVVQGADVFIGVSAEGALTEEMVRTMNDNAIIFAMANPVPEIMPELAK
AAGAAVVGTGRSDFANQVNNVLAFPGIFRGALDVHATQINEEMKMAAVQAIAELVAEDELNADYIIPAPFDARVAPQVAA
YVAKAAMETGVARRQVDPNEVAEKTKQLALIGKE

Sequences:

>Translated_434_residues
MFVVRPLGEIDISKNNLRRVDSLSTLREEALHMHKVHQGKLETVSKVKVENAKDLSLAYSPGVAEPCKEIYDDKSKVYEY
TMKGNMVAVVTDGTAVLGLGNIGPEASLPVMEGKAVLFKSFAGVDAFPIALNTNDVDKIVETVKLMEPTFGGVNLEDIAA
PNCFIIEERLKKETNIPIFHDDQHGTAIVTVAGLVNALKLVGKKMSDIKVVANGAGAAGIAIIKLLYRYGVRDIIMCDRK
GAIYEGRPTGMNPVKDEVAKYTNKNRIEGSLADVVQGADVFIGVSAEGALTEEMVRTMNDNAIIFAMANPVPEIMPELAK
AAGAAVVGTGRSDFANQVNNVLAFPGIFRGALDVHATQINEEMKMAAVQAIAELVAEDELNADYIIPAPFDARVAPQVAA
YVAKAAMETGVARRQVDPNEVAEKTKQLALIGKE
>Mature_434_residues
MFVVRPLGEIDISKNNLRRVDSLSTLREEALHMHKVHQGKLETVSKVKVENAKDLSLAYSPGVAEPCKEIYDDKSKVYEY
TMKGNMVAVVTDGTAVLGLGNIGPEASLPVMEGKAVLFKSFAGVDAFPIALNTNDVDKIVETVKLMEPTFGGVNLEDIAA
PNCFIIEERLKKETNIPIFHDDQHGTAIVTVAGLVNALKLVGKKMSDIKVVANGAGAAGIAIIKLLYRYGVRDIIMCDRK
GAIYEGRPTGMNPVKDEVAKYTNKNRIEGSLADVVQGADVFIGVSAEGALTEEMVRTMNDNAIIFAMANPVPEIMPELAK
AAGAAVVGTGRSDFANQVNNVLAFPGIFRGALDVHATQINEEMKMAAVQAIAELVAEDELNADYIIPAPFDARVAPQVAA
YVAKAAMETGVARRQVDPNEVAEKTKQLALIGKE

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=394, Percent_Identity=25.3807106598985, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI62420882, Length=395, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI62420880, Length=395, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI239049447, Length=395, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4505145, Length=405, Percent_Identity=25.1851851851852, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI270265879, Length=323, Percent_Identity=27.2445820433437, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788806, Length=409, Percent_Identity=51.5892420537897, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI87081919, Length=458, Percent_Identity=28.82096069869, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537199, Length=452, Percent_Identity=27.4336283185841, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322823, Length=311, Percent_Identity=30.5466237942122, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI78707242, Length=407, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI78707238, Length=407, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356279, Length=471, Percent_Identity=26.7515923566879, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI281362672, Length=471, Percent_Identity=26.7515923566879, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI281362674, Length=471, Percent_Identity=26.7515923566879, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646386, Length=448, Percent_Identity=26.3392857142857, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646388, Length=448, Percent_Identity=26.3392857142857, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI78707240, Length=400, Percent_Identity=26.75, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 46606; Mature: 46606

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVRPLGEIDISKNNLRRVDSLSTLREEALHMHKVHQGKLETVSKVKVENAKDLSLAYS
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEC
PGVAEPCKEIYDDKSKVYEYTMKGNMVAVVTDGTAVLGLGNIGPEASLPVMEGKAVLFKS
CCCHHHHHHHHCCHHHHEEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHH
FAGVDAFPIALNTNDVDKIVETVKLMEPTFGGVNLEDIAAPNCFIIEERLKKETNIPIFH
HCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEHHHHHHHCCCCEEE
DDQHGTAIVTVAGLVNALKLVGKKMSDIKVVANGAGAAGIAIIKLLYRYGVRDIIMCDRK
CCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCC
GAIYEGRPTGMNPVKDEVAKYTNKNRIEGSLADVVQGADVFIGVSAEGALTEEMVRTMND
CCEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHCCC
NAIIFAMANPVPEIMPELAKAAGAAVVGTGRSDFANQVNNVLAFPGIFRGALDVHATQIN
CEEEEEECCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHECCCHHHHHHHHHHHHHHH
EEMKMAAVQAIAELVAEDELNADYIIPAPFDARVAPQVAAYVAKAAMETGVARRQVDPNE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VAEKTKQLALIGKE
HHHHHHHHEEECCC
>Mature Secondary Structure
MFVVRPLGEIDISKNNLRRVDSLSTLREEALHMHKVHQGKLETVSKVKVENAKDLSLAYS
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEC
PGVAEPCKEIYDDKSKVYEYTMKGNMVAVVTDGTAVLGLGNIGPEASLPVMEGKAVLFKS
CCCHHHHHHHHCCHHHHEEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHH
FAGVDAFPIALNTNDVDKIVETVKLMEPTFGGVNLEDIAAPNCFIIEERLKKETNIPIFH
HCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEHHHHHHHCCCCEEE
DDQHGTAIVTVAGLVNALKLVGKKMSDIKVVANGAGAAGIAIIKLLYRYGVRDIIMCDRK
CCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCC
GAIYEGRPTGMNPVKDEVAKYTNKNRIEGSLADVVQGADVFIGVSAEGALTEEMVRTMND
CCEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHCCC
NAIIFAMANPVPEIMPELAKAAGAAVVGTGRSDFANQVNNVLAFPGIFRGALDVHATQIN
CEEEEEECCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHECCCHHHHHHHHHHHHHHH
EEMKMAAVQAIAELVAEDELNADYIIPAPFDARVAPQVAAYVAKAAMETGVARRQVDPNE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VAEKTKQLALIGKE
HHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]