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The map label for this gene is phoP [H]

Identifier: 118479736

GI number: 118479736

Start: 4394409

End: 4395128

Strand: Reverse

Name: phoP [H]

Synonym: BALH_4173

Alternate gene names: 118479736

Gene position: 4395128-4394409 (Counterclockwise)

Preceding gene: 118479737

Following gene: 118479735

Centisome position: 83.6

GC content: 35.97

Gene sequence:

>720_bases
ATGAACAATCGTATTTTAGTAGTTGATGATGAGGAGTTTATCTTAACTTTAATCGAATTTAATTTACAACAAGCTGGTTT
TGAAGTGATAACAGCGATGGATGGTGAGATGGCGCTGCAAAAAGCGACAACAGAACGTCCAGATTTAATTATATTAGATT
TAATGCTTCCAAAAATGGATGGTATGGAAGTATGTAAAGAATTACGATTGCAGCGCGTTATGACGCCAATTTTAATGTTA
ACAGCAAAAGATGATGAGTTTGATAAGGTGTTAGGTCTTGAACTTGGGGCGGATGATTATATGACGAAGCCATTTAGCCC
AAGGGAAGTTGTTGCACGTGTGAAGGCAATTTTACGCCGTACGAAATTACAACAAGAAGAGCAAGTTACAGAAACGTCAG
ATGAAGAGAGCATCACAATTGCTGAACTTAAAATTTTACCAGAGTTTTATGAGGCTTATTTCCAAGGAAGAAAGCTTGAA
TTAACACCAAAAGAATTTGAATTACTTGTTTATCTTGCGAAAAATAAGAGCCGTGTGTTGACGCGTGATCAATTATTAAG
TGCTGTATGGAATTATGATTTTGCTGGTGATACACGAATTGTTGACGTTCATATTAGCCATTTGCGCGATAAAATTGAAC
AAAATACGAAAAAACCGACGTACATTAAAACGATACGTGGTTTAGGATATAAATTAGAGGAGCCAAAAGGGGATGAATAA

Upstream 100 bases:

>100_bases
ACAATTATATTGAGAGGGACCTTGTTTTCTAGTATGATGAGAATAACGGGGAAAATACTAGGATGAAGAAGGTTTCAAGT
CTATAACTTGGAGGAAAAGA

Downstream 100 bases:

>100_bases
ATTTCGTTCCAGGCTTCTTTTTACATTTGTTTCTCTTATTGTGTTTATTTTAGTGGGACTCGGTTTATTGCTAGAAACCG
TGTTTGAAAACTACTATATA

Product: alkaline phosphatase synthesis response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MNNRILVVDDEEFILTLIEFNLQQAGFEVITAMDGEMALQKATTERPDLIILDLMLPKMDGMEVCKELRLQRVMTPILML
TAKDDEFDKVLGLELGADDYMTKPFSPREVVARVKAILRRTKLQQEEQVTETSDEESITIAELKILPEFYEAYFQGRKLE
LTPKEFELLVYLAKNKSRVLTRDQLLSAVWNYDFAGDTRIVDVHISHLRDKIEQNTKKPTYIKTIRGLGYKLEEPKGDE

Sequences:

>Translated_239_residues
MNNRILVVDDEEFILTLIEFNLQQAGFEVITAMDGEMALQKATTERPDLIILDLMLPKMDGMEVCKELRLQRVMTPILML
TAKDDEFDKVLGLELGADDYMTKPFSPREVVARVKAILRRTKLQQEEQVTETSDEESITIAELKILPEFYEAYFQGRKLE
LTPKEFELLVYLAKNKSRVLTRDQLLSAVWNYDFAGDTRIVDVHISHLRDKIEQNTKKPTYIKTIRGLGYKLEEPKGDE
>Mature_239_residues
MNNRILVVDDEEFILTLIEFNLQQAGFEVITAMDGEMALQKATTERPDLIILDLMLPKMDGMEVCKELRLQRVMTPILML
TAKDDEFDKVLGLELGADDYMTKPFSPREVVARVKAILRRTKLQQEEQVTETSDEESITIAELKILPEFYEAYFQGRKLE
LTPKEFELLVYLAKNKSRVLTRDQLLSAVWNYDFAGDTRIVDVHISHLRDKIEQNTKKPTYIKTIRGLGYKLEEPKGDE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=39.7435897435897, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=41.991341991342, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=39.5652173913043, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=42.5438596491228, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=40, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=38.034188034188, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=34.4827586206897, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=35.4978354978355, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=33.1877729257642, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=34.7639484978541, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=32.0675105485232, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=34.7457627118644, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=32.1739130434783, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.9012875536481, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=33.8709677419355, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=28.0821917808219, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=104, Percent_Identity=33.6538461538462, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27661; Mature: 27661

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRILVVDDEEFILTLIEFNLQQAGFEVITAMDGEMALQKATTERPDLIILDLMLPKMD
CCCCEEEEECHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCC
GMEVCKELRLQRVMTPILMLTAKDDEFDKVLGLELGADDYMTKPFSPREVVARVKAILRR
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHH
TKLQQEEQVTETSDEESITIAELKILPEFYEAYFQGRKLELTPKEFELLVYLAKNKSRVL
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEECHHHEEEEEEEECCCCCHH
TRDQLLSAVWNYDFAGDTRIVDVHISHLRDKIEQNTKKPTYIKTIRGLGYKLEEPKGDE
HHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNNRILVVDDEEFILTLIEFNLQQAGFEVITAMDGEMALQKATTERPDLIILDLMLPKMD
CCCCEEEEECHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCC
GMEVCKELRLQRVMTPILMLTAKDDEFDKVLGLELGADDYMTKPFSPREVVARVKAILRR
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHH
TKLQQEEQVTETSDEESITIAELKILPEFYEAYFQGRKLELTPKEFELLVYLAKNKSRVL
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEECHHHEEEEEEEECCCCCHH
TRDQLLSAVWNYDFAGDTRIVDVHISHLRDKIEQNTKKPTYIKTIRGLGYKLEEPKGDE
HHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]