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The map label for this gene is lonA

Identifier: 118479636

GI number: 118479636

Start: 4283157

End: 4285541

Strand: Reverse

Name: lonA

Synonym: BALH_4063

Alternate gene names: 118479636

Gene position: 4285541-4283157 (Counterclockwise)

Preceding gene: 118479637

Following gene: 118479635

Centisome position: 81.52

GC content: 38.78

Gene sequence:

>2385_bases
ATGTATTGTAATATAAAATGGTTGAACAGGAGTTTAATTTATTATGGAGGTGCTATGTCTAGTATGAATACGAATGAAAG
AATCGTACCCCTCCTACCATTAAGAGGCGTTCTCGTATATCCAACGATGGTTCTGCATCTTGATGTAGGACGTGATAAAT
CGATACAAGCACTAGAGCAGGCGGCAATGGATGAAAATATCATCTTTTTAGCAATGCAAAAAGAAATGAATATCGATGAT
CCGAAAGAAGATGACATATATAGTGTAGGTACAGTGGCGAAAGTGAAGCAAATGTTAAAATTGCCGAACGGTACGCTTCG
TGTCCTTGTAGAAGGTTTACATAGAGCAGAAGTAGTAGAGTTTATCGAAGAAGAAAATGTAGTGCAAGTTTCTATTAAAA
CGGTAACTGAAGAAGTGGAAGCTGATTTAGAAGAGAAAGCTCTTATGCGTACATTACTGGAGCATTTCGAACAATATATT
AAAGTTTCGAAAAAAGTTTCAAATGAAACATTTGCAACGGTAGCTGATGTAGAAGAGCCAGGAAGATTAGCAGATTTAAT
TGCTTCTCACTTGCCAATTAAAACGAAGCAGAAACAAGAGATTTTAGAAATCATATCTGTGAAAGAACGATTACATACAC
TTATTTCAATTATTCAAGATGAACAAGAATTACTTAGTTTAGAAAAGAAAATTGGACAAAAAGTGAAACGTTCAATGGAG
CGCACGCAAAAAGAATATTTCTTACGTGAGCAAATGAAGGCGATTCAAACTGAACTTGGCGATAAAGAAGGCAAGGGAGG
GGAAGTTGAAGAACTTCGTGAGAAAATTGAACAGTCAGGAATGCCTGAAGAAACAATGAAGGCTGCGCTGAAAGAATTAG
ATCGTTATGAAAAGTTACCAGCAAGTTCTGCGGAGAGCGGTGTTATTCGCAATTATATGGATTGGTTATTAGCACTTCCG
TGGACAGACGCAACGGAAGATATGATTGATCTTGCTCATTCGGAAGAGATTTTAAACAAAGATCATTACGGTCTTGAGAA
AGTGAAAGAGCGCGTACTGGAATATTTAGCGGTACAGAAGTTAACGAATTCATTAAAAGGGCCTATCCTTTGTTTAGTAG
GGCCACCTGGGGTCGGAAAAACTTCGTTAGCGCGTTCTATTGCGACATCATTAAATCGTAATTTTGTCCGTGTATCCCTT
GGTGGTGTGCGTGATGAATCTGAAATTCGTGGTCACCGTCGTACGTACGTTGGAGCAATGCCAGGACGCATTATTCAAGG
TATGAAAAAGGCAAAATCAGTTAATCCAGTCTTCTTATTAGATGAGATTGATAAAATGTCTAACGATTTCCGTGGAGATC
CTTCAGCAGCATTACTTGAAGTGTTAGATCCAGAACAAAACCATAACTTCAGTGATCATTATATTGAAGAACCATATGAT
CTATCGAAAGTTATGTTTGTAGCAACTGCGAATACACTTTCAAGTATTCCAGGCCCATTACTTGACCGTATGGAAATTAT
TTCGATTGCTGGCTATACAGAACTTGAAAAAGTTCATATTGCTCGTGAACATTTATTACCGAAACAATTACAAGAGCATG
GCTTACGAAAAGGTAATTTACAAGTACGTGATGAAGCGCTTCTTGAAATTATTCGCTATTATACACGTGAGGCTGGTGTT
CGTACACTAGAGCGCCAAATTGCAAAGGTTTGTCGTAAAGCAGCAAAAATTATCGTTACAGCAGAACGTAAGCGTATTGT
AGTAACAGAGAAAAACGTTGTTGATTTACTTGGTAAGCACATATTCCGTTATGGGCAAGCTGAAAAAACAGACCAAGTTG
GTATGGCGACAGGTTTAGCGTATACGGCAGCAGGCGGCGATACACTGGCGATTGAAGTGTCCGTAGCGCCAGGTAAAGGG
AAATTAATTTTAACAGGGAAACTTGGGGATGTTATGAAAGAATCCGCACAAGCGGCGTTTAGTTATATTCGTTCTCGTGC
AGAAGAGCTTCAGATTGATCCTGATTTCCATGAAAAAAATGATATTCATATTCATGTTCCAGAAGGAGCAGTTCCAAAAG
ATGGACCGTCAGCAGGTATTACGATGGCAACGGCACTTATTTCTGCGCTAACAGGTATTCCTGTAAGTAAAGAAGTGGGG
ATGACAGGTGAAATTACACTTCGTGGTCGTGTATTACCGATTGGTGGTTTAAAAGAAAAAACATTAAGTGCTCACCGCGC
AGGTTTAACAAAAATTATTTTACCGGCGGAAAATGAGAAAGATTTAGATGATATTCCAGAGAGCGTAAAAGAAAACCTTA
CGTTTGTGCTTGCATCTCATTTAGATGAAGTATTGGAGCACGCATTAGTAGGAGTGAAACAATGA

Upstream 100 bases:

>100_bases
TCGTTTAAGTTTGTATGCTTAAGCGGAGTCTTTTTTCTTTTCGTAAGAGAGAAAAAAAGCGGGATTTACAGTTGCGGAGA
ATCTCGGCAATTGCATCTAG

Downstream 100 bases:

>100_bases
AAGTAACAAAAGCAGACATTGTAATTAGTGCTGTTAAACCAGAACAATATCCAGACGGTGACTTACCAGAAATCGCATTA
GCAGGTCGTTCAAATGTCGG

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MYCNIKWLNRSLIYYGGAMSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDD
PKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYI
KVSKKVSNETFATVADVEEPGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSME
RTQKEYFLREQMKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALP
WTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSL
GGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYD
LSKVMFVATANTLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGV
RTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKG
KLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVG
MTGEITLRGRVLPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Sequences:

>Translated_794_residues
MYCNIKWLNRSLIYYGGAMSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDD
PKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYI
KVSKKVSNETFATVADVEEPGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSME
RTQKEYFLREQMKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALP
WTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSL
GGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYD
LSKVMFVATANTLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGV
RTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKG
KLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVG
MTGEITLRGRVLPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
>Mature_794_residues
MYCNIKWLNRSLIYYGGAMSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDD
PKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYI
KVSKKVSNETFATVADVEEPGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSME
RTQKEYFLREQMKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALP
WTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSL
GGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYD
LSKVMFVATANTLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGV
RTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKG
KLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVG
MTGEITLRGRVLPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=41.6666666666667, Blast_Score=584, Evalue=1e-166,
Organism=Homo sapiens, GI21396489, Length=684, Percent_Identity=43.2748538011696, Blast_Score=560, Evalue=1e-159,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=54.1069100391134, Blast_Score=841, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=40.02849002849, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=36.4331210191083, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=721, Percent_Identity=38.1414701803051, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=698, Percent_Identity=43.4097421203438, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221513036, Length=698, Percent_Identity=43.4097421203438, Blast_Score=560, Evalue=1e-159,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_BACAH (A0RJ87)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_896787.1
- ProteinModelPortal:   A0RJ87
- STRING:   A0RJ87
- MEROPS:   S16.001
- EnsemblBacteria:   EBBACT00000070330
- GeneID:   4542302
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_4063
- NMPDR:   fig|412694.5.peg.3913
- eggNOG:   COG0466
- GeneTree:   EBGT00050000000357
- HOGENOM:   HBG566281
- OMA:   IDPDFHE
- ProtClustDB:   CLSK873491
- BioCyc:   BTHU412694:BALH_4063-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 88612; Mature: 88612

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 697-697 ACT_SITE 740-740

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYCNIKWLNRSLIYYGGAMSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQ
CEEEEEECCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHH
AAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVE
HHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEP
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCC
GRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSME
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTQKEYFLREQMKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
ASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQK
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAM
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHEECCC
PGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYD
CHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
LSKVMFVATANTLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNL
HHHEEHEEEHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCC
QVRDEALLEIIRYYTREAGVRTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKH
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECHHHHHHHHHH
IFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAF
HHHCCCCCCCCHHHHHHCCEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHH
SYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVG
HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
MTGEITLRGRVLPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASH
CCEEEEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDEVLEHALVGVKQ
HHHHHHHHHCCCCC
>Mature Secondary Structure
MYCNIKWLNRSLIYYGGAMSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQ
CEEEEEECCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHH
AAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVE
HHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEP
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCC
GRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSME
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTQKEYFLREQMKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
ASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQK
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAM
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHEECCC
PGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYD
CHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
LSKVMFVATANTLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNL
HHHEEHEEEHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCC
QVRDEALLEIIRYYTREAGVRTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKH
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECHHHHHHHHHH
IFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAF
HHHCCCCCCCCHHHHHHCCEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHH
SYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVG
HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
MTGEITLRGRVLPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASH
CCEEEEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDEVLEHALVGVKQ
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA