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The map label for this gene is hisS [H]

Identifier: 118479561

GI number: 118479561

Start: 4197896

End: 4199326

Strand: Reverse

Name: hisS [H]

Synonym: BALH_3985

Alternate gene names: 118479561

Gene position: 4199326-4197896 (Counterclockwise)

Preceding gene: 118479562

Following gene: 118479560

Centisome position: 79.88

GC content: 39.48

Gene sequence:

>1431_bases
ATGAACGCACATTTAAGCGTTATTAAAAAAGTGGAAGCATACGTGCTTCAATTAGGGTGGCACCACGGGTATAATACTCT
CGTCCCTACTGTTCAAACAGTAGAGGCGGGAGTTTTTTTATTTTTATTAAGATTAAAACAATTTGAGGAGGAACTGAATA
TGTCTATTCAAATCCCACGCGGAACGCAAGATATTCTTCCAGGCACTGTTGAGTTATGGCAGTATATCGAAGGGCAAGCA
CGCGAAATTTGCCGTCGTTACAATTATAAAGAAATTCGTACACCGATTTTTGAACACACTGAGTTATTTTTACGTGGTGT
TGGTGATACGACAGATATCGTGCAAAAAGAAATGTACTCATTCCAAGATCGTGGAGAGCGTAGTTTAACATTACGTCCAG
AAGGCACTGCACCTGTTGTACGTTCTTACGTTGAAAACAAAATGTTCGGTGACGCAACACAACCAACGAAATTATATTAT
ATCGGTCAAATGTTCCGTTACGAAAGACCACAAGCAGGTCGCTATCGTCAATTCGTACAATTCGGTATTGAAGCAATCGG
TAGTAACGATCCTGCAATTGATGCGGAAGTAATTGCACTTGCTGTAGAGTTTTACCGAGGCATGGGCTTAAAAAATATTA
AAGTTGTATTAAACAGCTTAGGTGATGCAGCAAGCCGTCAAGCACACCGTGATGCGTTAATTGCACACTTCGAGCCACGT
ATCGGTGAGTTCTGTTCTGACTGTCAATCTCGTTTAGAAAAGAACCCTCTTCGTATTTTAGATTGTAAGAAGGACCGTAA
CCATGAATTAATGGGAACGGCACCATCTATTACAGAATACTTAAACGAAGATTCAGCAGTATACTACGAAAAAGTTCAAG
AACTATTAACGATGATGGATGTTCCATTTGAAAAAGATCCGAACTTAGTACGTGGTTTAGACTACTACCAGCACACTGTT
TTTGAAATTATGAGTGAAGCAGAAGGTTTCGGTGCGATCACTACACTAAGCGGTGGTGGACGTTACAACGGACTTGTACA
AGAAATCGGTGGACCAGAAATGCCAGGTATCGGTTTTGCGATGAGTATTGAACGTTTAATTATGGCGCTAAAAGCTGAAA
ATATTGAATTACCAATTGAACATAGTATTGATTGTTACGTTGTAGCGCTTGGTGAAAAAGCGAAAGACCATGCTGCAAAA
GTTGCGTTTGATCTTCGTAAAGCTGGATTAGCAGTTGAAAAAGATTATTTAGATCGCAAAATGAAAGCACAATTTAAATC
AGCAGATCGTCTAAAAGCGAAATTCGTAGCTGTACTAGGGGAAGATGAGCTAGATAAAGGCATCATTAACCTAAAAGATA
TGGCAACAGGCGAACAAGAAGAAGTAGCATTAGATGTGTTTGCTTCATACGTAGCAGAGAAATTAATATAG

Upstream 100 bases:

>100_bases
AAAGAGAAGAAATGTCTTAGGCTGAAAACATTTCTACATGATGACTGATTGAATGACACTCTAGAGGTTTCAACTTGAAC
GGCATATACGCTTAGTAGGG

Downstream 100 bases:

>100_bases
GGGGAACTTACAGTGGCTGAAAGAACACATGCATGTGGAAAAGTAACAGTAGAAGCAGTTGGACAAACAGTTCAATTAAA
AGGTTGGGTACAAAAACGCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase 2; HisRS 2 [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MNAHLSVIKKVEAYVLQLGWHHGYNTLVPTVQTVEAGVFLFLLRLKQFEEELNMSIQIPRGTQDILPGTVELWQYIEGQA
REICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYSFQDRGERSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYY
IGQMFRYERPQAGRYRQFVQFGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDAASRQAHRDALIAHFEPR
IGEFCSDCQSRLEKNPLRILDCKKDRNHELMGTAPSITEYLNEDSAVYYEKVQELLTMMDVPFEKDPNLVRGLDYYQHTV
FEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFAMSIERLIMALKAENIELPIEHSIDCYVVALGEKAKDHAAK
VAFDLRKAGLAVEKDYLDRKMKAQFKSADRLKAKFVAVLGEDELDKGIINLKDMATGEQEEVALDVFASYVAEKLI

Sequences:

>Translated_476_residues
MNAHLSVIKKVEAYVLQLGWHHGYNTLVPTVQTVEAGVFLFLLRLKQFEEELNMSIQIPRGTQDILPGTVELWQYIEGQA
REICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYSFQDRGERSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYY
IGQMFRYERPQAGRYRQFVQFGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDAASRQAHRDALIAHFEPR
IGEFCSDCQSRLEKNPLRILDCKKDRNHELMGTAPSITEYLNEDSAVYYEKVQELLTMMDVPFEKDPNLVRGLDYYQHTV
FEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFAMSIERLIMALKAENIELPIEHSIDCYVVALGEKAKDHAAK
VAFDLRKAGLAVEKDYLDRKMKAQFKSADRLKAKFVAVLGEDELDKGIINLKDMATGEQEEVALDVFASYVAEKLI
>Mature_476_residues
MNAHLSVIKKVEAYVLQLGWHHGYNTLVPTVQTVEAGVFLFLLRLKQFEEELNMSIQIPRGTQDILPGTVELWQYIEGQA
REICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYSFQDRGERSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYY
IGQMFRYERPQAGRYRQFVQFGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDAASRQAHRDALIAHFEPR
IGEFCSDCQSRLEKNPLRILDCKKDRNHELMGTAPSITEYLNEDSAVYYEKVQELLTMMDVPFEKDPNLVRGLDYYQHTV
FEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFAMSIERLIMALKAENIELPIEHSIDCYVVALGEKAKDHAAK
VAFDLRKAGLAVEKDYLDRKMKAQFKSADRLKAKFVAVLGEDELDKGIINLKDMATGEQEEVALDVFASYVAEKLI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=484, Percent_Identity=24.5867768595041, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI6996014, Length=461, Percent_Identity=24.9457700650759, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1788861, Length=420, Percent_Identity=41.6666666666667, Blast_Score=338, Evalue=7e-94,
Organism=Caenorhabditis elegans, GI71993693, Length=477, Percent_Identity=24.1090146750524, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993686, Length=477, Percent_Identity=24.1090146750524, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325290, Length=501, Percent_Identity=23.3532934131737, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643061, Length=476, Percent_Identity=24.7899159663866, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24643059, Length=495, Percent_Identity=23.8383838383838, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 53868; Mature: 53868

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHLSVIKKVEAYVLQLGWHHGYNTLVPTVQTVEAGVFLFLLRLKQFEEELNMSIQIPR
CCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GTQDILPGTVELWQYIEGQAREICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYS
CCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
FQDRGERSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYYIGQMFRYERPQAGRYRQFVQ
HHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCCCCCHHHHHHHH
FGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDAASRQAHRDALIAHFEPR
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHH
IGEFCSDCQSRLEKNPLRILDCKKDRNHELMGTAPSITEYLNEDSAVYYEKVQELLTMMD
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC
VPFEKDPNLVRGLDYYQHTVFEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCHHH
MSIERLIMALKAENIELPIEHSIDCYVVALGEKAKDHAAKVAFDLRKAGLAVEKDYLDRK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
MKAQFKSADRLKAKFVAVLGEDELDKGIINLKDMATGEQEEVALDVFASYVAEKLI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAHLSVIKKVEAYVLQLGWHHGYNTLVPTVQTVEAGVFLFLLRLKQFEEELNMSIQIPR
CCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GTQDILPGTVELWQYIEGQAREICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYS
CCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
FQDRGERSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYYIGQMFRYERPQAGRYRQFVQ
HHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCCCCCHHHHHHHH
FGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDAASRQAHRDALIAHFEPR
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHH
IGEFCSDCQSRLEKNPLRILDCKKDRNHELMGTAPSITEYLNEDSAVYYEKVQELLTMMD
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC
VPFEKDPNLVRGLDYYQHTVFEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCHHH
MSIERLIMALKAENIELPIEHSIDCYVVALGEKAKDHAAKVAFDLRKAGLAVEKDYLDRK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
MKAQFKSADRLKAKFVAVLGEDELDKGIINLKDMATGEQEEVALDVFASYVAEKLI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]