Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 118478797

GI number: 118478797

Start: 3379788

End: 3381314

Strand: Reverse

Name: argH [H]

Synonym: BALH_3189

Alternate gene names: 118478797

Gene position: 3381314-3379788 (Counterclockwise)

Preceding gene: 118478798

Following gene: 118478796

Centisome position: 64.32

GC content: 34.64

Gene sequence:

>1527_bases
GTGAAAGGGGAAAAGGTGATGAAACAAAGTAAAGAAGAGTTTATAAAGAGTGAAGGCGCTGATTTCCCTGGTAAAACATA
CGTGGATTGCGTATTACAACATGTATTTGAGTTTCAACGAAATTACTTATTGAAAGATATGTTTCAAGTGCATAAAGCGC
ATATTGTGATGTTGACGGAAGAAAATTTAATGAAAAAGGAAGAAGCTAAATTTATATTACACGCACTAAAAAAGGTTGAG
GAAATTCCAGAAGAGCAATTGCTCTATACAGAGCAGCATGAAGATCTCTTTTTTTTAGTGGAACATTTAATTTCTCAAGA
AGCAAAAAGCGATTTTGTAAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGGTGTAACGATGTATCGCATGAGTT
TAAGACGGTATGTATTACGATTAATGGAACATCATTTGTTATTGCAAGAAAGTATATTGCAACTTGCTACTGATCATAAG
GGAACGATTATGCCAGCTTATACACATACACAACCAGCTCAGCCAACAACATTTGGTCATTATACGTTAGCGATTTATGA
TACAATGCAGAGAGATTTAGAACGTATGAAAAAAACGTACAAACTTTTAAATCAATCGCCAATGGGAGCTGCTGCGCTTT
CTACAACAAGTTTCCCAATTAAACGAGAGCGAGTTGCCGATTTACTTGGATTTACTAATGTAATTGAGAACTCATATGAT
GCTGTCGCTGGAGCGGATTATTTATTAGAGGTTAGCTCGTTACTTATGGTAATGATGACGAATACGAGTAGATGGATTCA
TGATTTCTTACTATTAGCGACGAAAGAATATGATGGTATTACTGTTGCAAGGCCGTATGTACAAATTAGTAGTATTATGC
CACAAAAGCGAAATCCAGTTTCAATTGAACACGCCCGTGCAATTACGAGTAGTGCTCTAGGGGAAGCATTTACAGTATTT
CAAATGATTCATAATACACCGTTTGGTGATATTGTCGATACGGAAGATGACTTGCAGCCGTATTTATATAAAGGAATTGA
AAAGGCTATTCGTGTATTTTGCATTTTGAATGCAGTCATTCGGACGATGAAAGTAGAAGAGGATACTTTAAAAAGACGTT
CATATAAACATGCAATTACGATTACAGATTTCGCAGATGTTTTAACGAAAAACTATGGCATCCCATTTCGGCATGCCCAT
CATGCGGCAAGTGTTATTGCGAATATGTCGTTGGAACAGAAAAAGGAGCTACATGAATTATGTTTCAAAGGTGTAAATAT
ATACTTACAAGAAAAATTTAAAATACAATTATTAGAAAAAGAGTGGGAAGAAATTATATCGCCAGAAGCTTTTATACAAA
AAAGAAATGTATATGGTGGACCGAGTAAAAAAGAAATGGAGCGCATGATTAACAATCGAAAAGAGTTATTTCGAAAAGAA
GAAGAGGTATTTGAAAAGGAAAAACAGAGGGTTTTACAAGCTGAAAATGATTTGAATATGTTAGCTTCGAATATTATTGA
ATCGTAA

Upstream 100 bases:

>100_bases
CGACTTTTATTAAGTAAACTCGGTGCAGAGAGCACCGAGTTTATTTTTGTGTACAAGCACTTTTTTCCTATCTCTGGGTA
TGATGGGTAGTAATACTTAG

Downstream 100 bases:

>100_bases
AAGAGGGATTTAATGAATTAATCGCCAATACTTAATAAAACTATAAATGGAGAGAAGAGATTGTCGATGATTCAATTACA
TGTATATGAAGAGGTTGTTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKGEKVMKQSKEEFIKSEGADFPGKTYVDCVLQHVFEFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVE
EIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHK
GTIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYD
AVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVF
QMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAH
HAASVIANMSLEQKKELHELCFKGVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKE
EEVFEKEKQRVLQAENDLNMLASNIIES

Sequences:

>Translated_508_residues
MKGEKVMKQSKEEFIKSEGADFPGKTYVDCVLQHVFEFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVE
EIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHK
GTIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYD
AVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVF
QMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAH
HAASVIANMSLEQKKELHELCFKGVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKE
EEVFEKEKQRVLQAENDLNMLASNIIES
>Mature_508_residues
MKGEKVMKQSKEEFIKSEGADFPGKTYVDCVLQHVFEFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVE
EIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHK
GTIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYD
AVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVF
QMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAH
HAASVIANMSLEQKKELHELCFKGVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKE
EEVFEKEKQRVLQAENDLNMLASNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=376, Percent_Identity=27.9255319148936, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI68303542, Length=376, Percent_Identity=27.9255319148936, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI68303547, Length=376, Percent_Identity=28.1914893617021, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI68303549, Length=376, Percent_Identity=25.7978723404255, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1790398, Length=417, Percent_Identity=28.7769784172662, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321806, Length=421, Percent_Identity=28.7410926365796, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221473854, Length=386, Percent_Identity=28.4974093264249, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI78706858, Length=386, Percent_Identity=28.4974093264249, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 59049; Mature: 59049

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGEKVMKQSKEEFIKSEGADFPGKTYVDCVLQHVFEFQRNYLLKDMFQVHKAHIVMLTE
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
ENLMKKEEAKFILHALKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHKGTIMPAYTHTQPAQPTTFGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
YTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
AVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCC
SIEHARAITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHEL
HHHHCCHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
CFKGVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKE
HHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EEVFEKEKQRVLQAENDLNMLASNIIES
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGEKVMKQSKEEFIKSEGADFPGKTYVDCVLQHVFEFQRNYLLKDMFQVHKAHIVMLTE
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
ENLMKKEEAKFILHALKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHKGTIMPAYTHTQPAQPTTFGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
YTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
AVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCC
SIEHARAITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHEL
HHHHCCHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
CFKGVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKE
HHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EEVFEKEKQRVLQAENDLNMLASNIIES
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]