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The map label for this gene is phr [H]

Identifier: 118478461

GI number: 118478461

Start: 2998290

End: 2999720

Strand: Reverse

Name: phr [H]

Synonym: BALH_2833

Alternate gene names: 118478461

Gene position: 2999720-2998290 (Counterclockwise)

Preceding gene: 118478462

Following gene: 118478460

Centisome position: 57.06

GC content: 34.94

Gene sequence:

>1431_bases
ATGCAAAATAAAATTATCGTTATGTTTCAAAAAGATTTTCGCTTATATGATAACCCAGCTCTATTTGAAGCTGCTCAGTC
CGGTGAGGTTGTTCCGGTATATGTACATGACGAAACTTTTTCAATAGGAAGTGCGTCAAAGTGGTGGTTACACCATGCAA
TAATAGATGTAAAGAAGCAACTTGAGGCATTGGGCTCTACTTTAATCATTCGTAAAGGAAGTACGGAGGAAGAAATACTT
TCTCTCATAGAACAGTTAGGTATAACGGCTGTATATTGGAATATTTGTTATGATCCGGACAGATTGCAATTTAATCAAAA
AATGAAAATGATGTTAGAAGATAAAGGTATGATCTGTAAGGAATTTAATTCACATTTATTATTAGAGCCTTGGGTTATTA
AAAAGAAAGATAACACTGAATATAAGGTGTTTACGCCTTTTTACAATGCATTTCAAAAGCAGGTAATACATAAGCCTATT
AGTAAAGTGCAGAGTATAAAGGGAGGAAACTCTTTACCATCAAGCTTATCTGTTTCAGAATTACACTTGTTGCCGACTAT
ACCGTGGACATCTCATATGGAATCAATATGGGAGCCTACAGAAGAAGGGGCATACAAAACATGTAAGAAATTTTTCTCTA
GCAAACTGGCCTCTTATAGTGAAGGAAGAGATTTTCCAAATCAAAATGCTCATTCGATGTTGGCACCTTATCTTTCATTT
GGTCAAATATCAGTCAAGCTAATATATCATTACTTAATAAATAAAAGTACCGAAAGCCAATGTAGTCTTTTTGAAAAACA
AGTAAATAGTTTTATACGTCAATTAATTTGGCGAGAGTTTTCTTATTATATGCTATATCATTATCCATTTACAGCATATA
AACCTCTTAATAAGAGCTTTGAACATTTTCCGTGGAATAATGAAAAGGAGTTATTAAGAGTATGGCAGAAAGGTGAAACT
GGTTATCCGTTTATTGATGCCGGAATGAGGGAACTGTGGCAAACAGGTTTTATGCATAATCGCACAAGAATGGCTGTAGC
CTCTTTTCTTATAAAGCATTTGTTAATTCCGTGGCAAGAAGGAGCAAAATGGTTTATGGATACACTATTAGATGCTGATA
TTGCAAATAATACAATGGGGTGGCAATGGGTTGCTGGAAGTGGAGCAGATGCATCACCATACTTTCGTATTTTTAATCCG
ATCACACAAGGAGAAAAGTTTGATAAAAACGGAGAGTATATAAGAAAATGGGTACCAGAATTAAAAGATATGCCTAATAA
ATATATACATAAACCGTGGGAAGCACCTGAGCATATTTTACAAAAGGCCAATATACAGCTTGGTCATACATATCCTTTGC
CAGTCGTTGATCATAAGGCTGCACGAGAGAGAGCGCTTTGTGCATATAAAAGTATGAAAGAATTCGTATGA

Upstream 100 bases:

>100_bases
TACCCCCACCTCAAAAATCAACGGAAGCAAAGAAGTTAGGTGGGGATCGGGTTGATTAAAGTTTCACTTTATTATGTTTT
AAGAATGAGAAAGGATAGCC

Downstream 100 bases:

>100_bases
AATAGGTTAAACAATATGTATTTAAAATTTAAATATTAGAAATTTATCCATTACAAGGACATACTAATCATATAAAGTTT
CTAAAACCTTCTATTGAAAA

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MQNKIIVMFQKDFRLYDNPALFEAAQSGEVVPVYVHDETFSIGSASKWWLHHAIIDVKKQLEALGSTLIIRKGSTEEEIL
SLIEQLGITAVYWNICYDPDRLQFNQKMKMMLEDKGMICKEFNSHLLLEPWVIKKKDNTEYKVFTPFYNAFQKQVIHKPI
SKVQSIKGGNSLPSSLSVSELHLLPTIPWTSHMESIWEPTEEGAYKTCKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLIYHYLINKSTESQCSLFEKQVNSFIRQLIWREFSYYMLYHYPFTAYKPLNKSFEHFPWNNEKELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRTRMAVASFLIKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRKWVPELKDMPNKYIHKPWEAPEHILQKANIQLGHTYPLPVVDHKAARERALCAYKSMKEFV

Sequences:

>Translated_476_residues
MQNKIIVMFQKDFRLYDNPALFEAAQSGEVVPVYVHDETFSIGSASKWWLHHAIIDVKKQLEALGSTLIIRKGSTEEEIL
SLIEQLGITAVYWNICYDPDRLQFNQKMKMMLEDKGMICKEFNSHLLLEPWVIKKKDNTEYKVFTPFYNAFQKQVIHKPI
SKVQSIKGGNSLPSSLSVSELHLLPTIPWTSHMESIWEPTEEGAYKTCKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLIYHYLINKSTESQCSLFEKQVNSFIRQLIWREFSYYMLYHYPFTAYKPLNKSFEHFPWNNEKELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRTRMAVASFLIKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRKWVPELKDMPNKYIHKPWEAPEHILQKANIQLGHTYPLPVVDHKAARERALCAYKSMKEFV
>Mature_476_residues
MQNKIIVMFQKDFRLYDNPALFEAAQSGEVVPVYVHDETFSIGSASKWWLHHAIIDVKKQLEALGSTLIIRKGSTEEEIL
SLIEQLGITAVYWNICYDPDRLQFNQKMKMMLEDKGMICKEFNSHLLLEPWVIKKKDNTEYKVFTPFYNAFQKQVIHKPI
SKVQSIKGGNSLPSSLSVSELHLLPTIPWTSHMESIWEPTEEGAYKTCKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLIYHYLINKSTESQCSLFEKQVNSFIRQLIWREFSYYMLYHYPFTAYKPLNKSFEHFPWNNEKELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRTRMAVASFLIKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRKWVPELKDMPNKYIHKPWEAPEHILQKANIQLGHTYPLPVVDHKAARERALCAYKSMKEFV

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=515, Percent_Identity=29.3203883495146, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4758072, Length=481, Percent_Identity=30.1455301455301, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI188536103, Length=476, Percent_Identity=28.5714285714286, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1786926, Length=482, Percent_Identity=33.402489626556, Blast_Score=278, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6324962, Length=509, Percent_Identity=28.4872298624754, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17137248, Length=503, Percent_Identity=28.2306163021869, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585455, Length=503, Percent_Identity=28.2306163021869, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24648152, Length=511, Percent_Identity=25.2446183953033, Blast_Score=145, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55636; Mature: 55636

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKIIVMFQKDFRLYDNPALFEAAQSGEVVPVYVHDETFSIGSASKWWLHHAIIDVKKQ
CCCCEEEEEECCCEECCCCHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LEALGSTLIIRKGSTEEEILSLIEQLGITAVYWNICYDPDRLQFNQKMKMMLEDKGMICK
HHHCCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHH
EFNSHLLLEPWVIKKKDNTEYKVFTPFYNAFQKQVIHKPISKVQSIKGGNSLPSSLSVSE
HCCCCEEECCEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LHLLPTIPWTSHMESIWEPTEEGAYKTCKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
EEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
GQISVKLIYHYLINKSTESQCSLFEKQVNSFIRQLIWREFSYYMLYHYPFTAYKPLNKSF
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCC
EHFPWNNEKELLRVWQKGETGYPFIDAGMRELWQTGFMHNRTRMAVASFLIKHLLIPWQE
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
GAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNPITQGEKFDKNGEYIRKWVPE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHCCCCCCCCHHHHHHHHHH
LKDMPNKYIHKPWEAPEHILQKANIQLGHTYPLPVVDHKAARERALCAYKSMKEFV
HHCCCHHHHCCCCCCHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKIIVMFQKDFRLYDNPALFEAAQSGEVVPVYVHDETFSIGSASKWWLHHAIIDVKKQ
CCCCEEEEEECCCEECCCCHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LEALGSTLIIRKGSTEEEILSLIEQLGITAVYWNICYDPDRLQFNQKMKMMLEDKGMICK
HHHCCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHH
EFNSHLLLEPWVIKKKDNTEYKVFTPFYNAFQKQVIHKPISKVQSIKGGNSLPSSLSVSE
HCCCCEEECCEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LHLLPTIPWTSHMESIWEPTEEGAYKTCKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
EEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
GQISVKLIYHYLINKSTESQCSLFEKQVNSFIRQLIWREFSYYMLYHYPFTAYKPLNKSF
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCC
EHFPWNNEKELLRVWQKGETGYPFIDAGMRELWQTGFMHNRTRMAVASFLIKHLLIPWQE
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
GAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNPITQGEKFDKNGEYIRKWVPE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHCCCCCCCCHHHHHHHHHH
LKDMPNKYIHKPWEAPEHILQKANIQLGHTYPLPVVDHKAARERALCAYKSMKEFV
HHCCCHHHHCCCCCCHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]