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The map label for this gene is proC [H]

Identifier: 118478443

GI number: 118478443

Start: 2977201

End: 2978019

Strand: Reverse

Name: proC [H]

Synonym: BALH_2813

Alternate gene names: 118478443

Gene position: 2978019-2977201 (Counterclockwise)

Preceding gene: 118478444

Following gene: 118478442

Centisome position: 56.65

GC content: 34.07

Gene sequence:

>819_bases
ATGAATAAACAAATAGGATTCATCGGATGTGGAAATATGGGTATTGCTATGATAGGTGGGATGATTAACAAAAATATAGT
GTCTCCAGATCAAATAATTTGTTCAGATTTAAACGTTAGTAATTTGAAAAATGCTAGTGATAAATATGGCATAACTATAA
CTACTAACAACAATGAAGTCGCTAACAGTGCTGACATTTTAATTTTATCAATCAAACCAGATTTATACTCATCGGTAATT
AACCAAATAAAAGATCAAATAAAAAATGATGTAATCGTTGTAACTATTGCTGCAGGAAAAAGTATTAAGAGCACTGAGAA
TGAATTTGATAGAAAGTTAAAGGTTATTAGGGTAATGCCTAATACACCGGTACTTGTTGGAGAAGGAATGTCTGCGTTAT
GTTTTAATGAAATGGTTACAGAAAAAGATATAAAAGAGGTACTGAACATATTTAATATTTTCGGCCAGACGGAGGTCGTA
AATGAAAAACTAATGGATGTTGTTACATCTATTAGTGGTTCTTCTCCAGCATATGTGTATATGTTTATAGAAGCCATGGC
AGACGCTGCTGTACTTGGCGGTATGGCGAGAAAACAAGCTTATAAATTTGCGGCTCAGGCTGTATTAGGTTCTGCAAAAA
TGGTATTGGAAACAGGAATACATCCAGGTGAATTGAAGGATATGGTTTGTTCTCCAGGTGGAACGACAATAGAAGCCGTA
GCAATACTAGAAGCAAAAGGTTTAAGAACAGCTATCATTTCAGCTATGAAACGTTGTACGCAAAAATCTATGGAAATGTC
TAGTTTAACTAGTAAGTGA

Upstream 100 bases:

>100_bases
AAATTCTATTGATAAACCTAGTAATTGTAATAGCCCTTATTTAGAATAATATTTTCAAAATCAATAAAATTTAGAGTAGA
AGGAGCAAGAGCAAATTATT

Downstream 100 bases:

>100_bases
GAAGTGAATTTATATAATATTTCAAATCTATTTAATGTAAAAGAAATATTATGAGGCTAGTTAATAACTAAGTAAATTTA
TATACAACAATAATGAGAAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPDQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMARKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
AILEAKGLRTAIISAMKRCTQKSMEMSSLTSK

Sequences:

>Translated_272_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPDQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMARKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
AILEAKGLRTAIISAMKRCTQKSMEMSSLTSK
>Mature_272_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPDQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMARKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
AILEAKGLRTAIISAMKRCTQKSMEMSSLTSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=36.6300366300366, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=35.1648351648352, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=35.1648351648352, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=35.0943396226415, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=53.5580524344569, Blast_Score=293, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=37.5478927203065, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=33.6842105263158, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=26.3157894736842, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=37.8181818181818, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=35.8208955223881, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=41.2790697674419, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29215; Mature: 29215

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQIGFIGCGNMGIAMIGGMINKNIVSPDQIICSDLNVSNLKNASDKYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHCCCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMP
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHEEEEEECC
NTPVLVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVVNEKLMDVVTSISGSSPAYVY
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLGGMARKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEE
AILEAKGLRTAIISAMKRCTQKSMEMSSLTSK
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKQIGFIGCGNMGIAMIGGMINKNIVSPDQIICSDLNVSNLKNASDKYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHCCCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMP
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHEEEEEECC
NTPVLVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVVNEKLMDVVTSISGSSPAYVY
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLGGMARKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEE
AILEAKGLRTAIISAMKRCTQKSMEMSSLTSK
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]