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The map label for this gene is clpP [H]

Identifier: 118478148

GI number: 118478148

Start: 2668090

End: 2668686

Strand: Reverse

Name: clpP [H]

Synonym: BALH_2505

Alternate gene names: 118478148

Gene position: 2668686-2668090 (Counterclockwise)

Preceding gene: 118478149

Following gene: 118478146

Centisome position: 50.76

GC content: 35.01

Gene sequence:

>597_bases
TTGGAGGGATTTAAAATGAATGTAATTCCATATGTTGTAGAACAAACGAAATTAGGAGAACGTTCCTATGATATATATTC
AAGGTTATTGAAAGACCGTATTGTTATTATCGGTTCAGAAATAAATGATCAAGTAGCGAGTAGTGTCGTAGCTCAATTAT
TATTTTTAGAAGCAGAAGATGCAGAGAAAGATATATTTTTATACATTAATAGCCCAGGCGGATCAACGACAGCAGGTTTT
GCTATATTAGATACGATGAATTTAATTAAACCAGACGTGCAAACGCTATGCATGGGCTTTGCAGCATCATTTGGTGCATT
GTTATTATTATCAGGTGCAAAAGGAAAACGATTTGCACTCCCAAATAGTGAAATTATGATTCATCAGCCACTTGGTGGTG
CGCAAGGGCAAGCGACGGAAATCGAAATCACAGCAAAAAGAATTTTAAAGTTAAAACATGATATTAATAAAATGATTGCA
GAAAAAACAGGGCAACCGATTGAAAGAGTAGCACATGATACAGAAAGAGATTATTTTATGACTGCAGAAGAAGCGAAGGC
ATATGGGATTGTAGATGATGTTGTTACGAAAAAATAG

Upstream 100 bases:

>100_bases
AATAGATTTTACTAAGTTACCATCTAAACAGCCAGTCTTATTATTTAATGTGAAACAACCTTCTTCCTACAGTTGTATGC
TTTGCGTTGCATAACAATTA

Downstream 100 bases:

>100_bases
CAGAAAGCAGGCTAGAGAGTAAAGTATAATCTCTAGCCTGTTTTATTAATCTTTTATCCATTCATCGACTAACGCTTGAT
TCTTTTTAATCCATTTTCGC

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MEGFKMNVIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGF
AILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIA
EKTGQPIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Sequences:

>Translated_198_residues
MEGFKMNVIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGF
AILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIA
EKTGQPIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK
>Mature_198_residues
MEGFKMNVIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGF
AILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIA
EKTGQPIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=53.6842105263158, Blast_Score=206, Evalue=1e-53,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=60.6217616580311, Blast_Score=256, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=49.4736842105263, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=54.4502617801047, Blast_Score=219, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21799; Mature: 21799

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGFKMNVIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAED
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCC
AEKDIFLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFAL
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCEEEC
PNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFM
CCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEE
TAEEAKAYGIVDDVVTKK
EHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MEGFKMNVIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAED
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCC
AEKDIFLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFAL
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCEEEC
PNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFM
CCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEE
TAEEAKAYGIVDDVVTKK
EHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]