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The map label for this gene is vanR [H]

Identifier: 118477956

GI number: 118477956

Start: 2471466

End: 2472212

Strand: Reverse

Name: vanR [H]

Synonym: BALH_2302

Alternate gene names: 118477956

Gene position: 2472212-2471466 (Counterclockwise)

Preceding gene: 118477972

Following gene: 118477955

Centisome position: 47.03

GC content: 30.25

Gene sequence:

>747_bases
ATGTTTGATATTATAGTAATGTTAATGATTTGTAAGGAAAGGAACTACATAATGAATAAAAATATATTAATTATTGATGA
TGATAAAGAAATTGTCGAATTACTTGCTGTTTATTTGCGAAATGAAGGCTATAACATTTATAAAGCATATGATGGTGATG
ATGCATTACAAATGATTTCTACATATGAAGTTGACCTTATGATTTTGGATATTATGATGCCAAAACGAAATGGATTAGAA
GTTTGCCAAGAAGTTCGTGAAAATAATACTGTACCTATTCTTATGCTGAGTGCAAAAGCAGAAGATATGGATAAAATATT
AGGACTTATGACAGGCGCCGATGATTATATGATTAAACCATTTAATCCATTAGAATTAGTAGCTAGAGTGAAAGCTTTGC
TTCGACGATCATCTTTCCAAAATGCTTCTTCTCCCAAAAATGAAGATGGTATGATTCGCATTCGTTCTGCTGAAATACAC
AAACATAATCATACTGTGAAAGTAAATGGAGAATATATTAAGCTTACATCTATTGAATTTGATATTTTATATTTACTTGC
GAGTAATACAGGAAGAGTATTTAGTTCTGAAGAAATATTTGAGCGTGTTTGGAATGAAGATGGTTATGGTTCAAATAAAA
CTGTAATGGTCCACATTAGTAATTTACGAGATAAGCTTGAAACAGGAATGAATGGAGAAAAATTTATTCATACTGTTTGG
GGAGTAGGCTATAAAATTGAGAAATGA

Upstream 100 bases:

>100_bases
TTTAAATATCCTTTTTATTTGTATTCGTTATAAATGTTGTAATCCCTTTTTTAATACGTTACATGAAATTTTATACAGAA
TCATCGCTACAAGTACATAA

Downstream 100 bases:

>100_bases
AGCATTTGATATATTAAAAGATATCCCGAAATGGAAACTTATTTTTTGGCTCTTATTAGCTATCACACTCACTCCTATTA
CTGAATTAATTATATATCGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MFDIIVMLMICKERNYIMNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDDALQMISTYEVDLMILDIMMPKRNGLE
VCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIH
KHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVW
GVGYKIEK

Sequences:

>Translated_248_residues
MFDIIVMLMICKERNYIMNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDDALQMISTYEVDLMILDIMMPKRNGLE
VCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIH
KHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVW
GVGYKIEK
>Mature_248_residues
MFDIIVMLMICKERNYIMNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDDALQMISTYEVDLMILDIMMPKRNGLE
VCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIH
KHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVW
GVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=35.8078602620087, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.117903930131, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.4827586206897, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.4561403508772, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790863, Length=239, Percent_Identity=31.7991631799163, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=32.034632034632, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.6206896551724, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=33.6322869955157, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=33.9285714285714, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=34.1880341880342, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.7180616740088, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=29.5154185022026, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=31.25, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=105, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28589; Mature: 28589

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIIVMLMICKERNYIMNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDDALQMIS
CHHHHHHHHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
TYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKP
HHCEEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEECC
FNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEF
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEE
DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVW
EEEEEEECCCCCEECHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHH
GVGYKIEK
CCCEEECC
>Mature Secondary Structure
MFDIIVMLMICKERNYIMNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDDALQMIS
CHHHHHHHHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
TYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKP
HHCEEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEECC
FNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEF
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEE
DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVW
EEEEEEECCCCCEECHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHH
GVGYKIEK
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]