Click here to switch to the map view.

The map label for this gene is thrS [H]

Identifier: 118477787

GI number: 118477787

Start: 2281269

End: 2283188

Strand: Direct

Name: thrS [H]

Synonym: BALH_2125

Alternate gene names: 118477787

Gene position: 2281269-2283188 (Clockwise)

Preceding gene: 118477786

Following gene: 118477788

Centisome position: 43.39

GC content: 34.64

Gene sequence:

>1920_bases
ATGAAAGAACAGATGATTGAAATTAAATTTCCAGATGGTAGCGTGAAAGAATTTGTAAAAGGAATTACTTTAGAAGAAAT
TGCTGGATCCATTAGCAGTAGCTTAAAAAAGAAAGCAGTTGCAGGGAAAGTAAATGATGAGTTATATGATTTACGCCGAA
ATATTGAAGAAAATGCGGAAGTAGAAATCATTACTATAGATTCAAATGAAGGTGTAGAAATTGCAAGGCACTCTGCGGCA
CATATTTTAGCGCAAGCTGTAAAAAGATTGTATGGTGATATAAATCTTGGAGTAGGGCCTGTTATTGAAAATGGATTTTA
TTATGATATGGATTTTCCGAGTAGTGTAAACGTAGAAGATTTACGAAAAATCGAAAAAGAAATGAAAAAGATTATAAATG
AAAATATAAAGATAGAACGAGTTGAGGTTTCTCGAGAAGAAGCAGCTAAACTGTTTCAAGAAATGAACGATCGATTGAAA
TTAGAACTTTTAGAAGCAATTCCTAGTGGGGAAAGTGTAACACTATATAAACAAGGTGAATTTGTAGATTTATGTAGAGG
TCCACATTTACCGTCAACAGGTTATTTGAAAGCATTTCAATTAACTCACGTTTCCGGTGCATATTGGCGAGGAGATAGTA
ATAATCAAGTGCTTCAGCGTATATATGGTGTTGCATTCTCTTCTCAGAAAGAATTAGAAGAGTATTTACATTTCGTTGAA
GAAGCAGCCAAAAGAAACCATCGTAAGTTAGGCAATGAACTGGAGCTATTTATGTTTTCTGAAGAGGCTCCGGGAATGCC
GTTTTATTTACCGAAAGGCCAAATTATTCGTAATGAATTAGAAGCTTTTTTAAGAGAAATTCAAAAAGAATATAATTATC
AAGAAGTACGCACTCCATTCATGATGAACCAAGAAGTATGGGAAAGATCAGGGCACTGGGGACATTATAAAGATAATATG
TATTTCTCAGAAGTGGATAATAAAAGTTTTGCATTAAAACCGATGAACTGCCCAGGGCATATGCTAATGTTCAAAAATAA
ATTGCATTCTTATCGCGAATTACCGATTCGTATGTGTGAGTTTGGTCAAGTACATCGCCATGAATTTAGTGGGGCGTTAA
ACGGATTATTAAGAGTACGTACTTTCTGCCAAGATGATGCTCATTTATTTGTAACACCAGAACAAATTGAAGATGAAATC
AAATCTGTAATGGCGCAAATCGATTATGTATATAAAACTTTTGGATTCGAATATGAAGTAGAACTTTCTACTCGTCCAGA
AGATTCAATGGGTGATGATAAGTTATGGGAGCAAGCAGAAGCGTCATTAGAAAATGTATTACAATCGCTAAATTATAAAT
ATAGACTAAATGAAGGTGATGGTGCATTTTACGGACCGAAAATTGACTTCCATATTAAAGATGCTTTAAATAGAAGTCAT
CAGTGCGGAACAATCCAGCTAGATTTCCAAATGCCAGAGAAGTTTGATTTAAATTATATAGATGAGAAGAATGAAAAGAA
AAGACCGGTTGTCATTCACAGAGCAGTATTAGGATCTTTAGATCGTTTCTTAGCAATATTAATTGAGCACTTTGGAGGTG
CATTCCCAGCATGGGTGGCACCAGTTCAAGTGAAAGTCATTCCAGTTTCAAATGCAGTCCATGTACAATACGCAGATGAG
GTTGCAGATAAATTAGCACAAGCTGGTGTTCGTGTCGAACGAGATATGCGAGATGAAAAATTAGGATATAAAATAAGAGA
AGCACAAATGCAAAAAGTTCCTTATGTTCTTGTTATTGGTGATAAGGAAATGGAAAACGGAGCTGTAAATGTGCGTAAAT
ATGGGGAAGAAAAATCAGGTGTAATTGAACTAGATATGTTTGTGGAAAGTATGAAAGAGGAAATTAAAAATAGAAAATAG

Upstream 100 bases:

>100_bases
ATGTTTGTGATGGGAATCTGGGTGGAACCACGGGTAAAAGCACGCTCGTCCCTATTGTAGGGATGAGTGTGCTTTTTATT
ATGAAATGGAGAGATGAAAA

Downstream 100 bases:

>100_bases
AGTTGATAAGAAAATATGTCATTAATATGTATTGCTGAATTTAAGATAATTAAATAAATATAATAATTATTGCACAACGA
CGTATGTTGTTTTAAGGCGT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MKEQMIEIKFPDGSVKEFVKGITLEEIAGSISSSLKKKAVAGKVNDELYDLRRNIEENAEVEIITIDSNEGVEIARHSAA
HILAQAVKRLYGDINLGVGPVIENGFYYDMDFPSSVNVEDLRKIEKEMKKIINENIKIERVEVSREEAAKLFQEMNDRLK
LELLEAIPSGESVTLYKQGEFVDLCRGPHLPSTGYLKAFQLTHVSGAYWRGDSNNQVLQRIYGVAFSSQKELEEYLHFVE
EAAKRNHRKLGNELELFMFSEEAPGMPFYLPKGQIIRNELEAFLREIQKEYNYQEVRTPFMMNQEVWERSGHWGHYKDNM
YFSEVDNKSFALKPMNCPGHMLMFKNKLHSYRELPIRMCEFGQVHRHEFSGALNGLLRVRTFCQDDAHLFVTPEQIEDEI
KSVMAQIDYVYKTFGFEYEVELSTRPEDSMGDDKLWEQAEASLENVLQSLNYKYRLNEGDGAFYGPKIDFHIKDALNRSH
QCGTIQLDFQMPEKFDLNYIDEKNEKKRPVVIHRAVLGSLDRFLAILIEHFGGAFPAWVAPVQVKVIPVSNAVHVQYADE
VADKLAQAGVRVERDMRDEKLGYKIREAQMQKVPYVLVIGDKEMENGAVNVRKYGEEKSGVIELDMFVESMKEEIKNRK

Sequences:

>Translated_639_residues
MKEQMIEIKFPDGSVKEFVKGITLEEIAGSISSSLKKKAVAGKVNDELYDLRRNIEENAEVEIITIDSNEGVEIARHSAA
HILAQAVKRLYGDINLGVGPVIENGFYYDMDFPSSVNVEDLRKIEKEMKKIINENIKIERVEVSREEAAKLFQEMNDRLK
LELLEAIPSGESVTLYKQGEFVDLCRGPHLPSTGYLKAFQLTHVSGAYWRGDSNNQVLQRIYGVAFSSQKELEEYLHFVE
EAAKRNHRKLGNELELFMFSEEAPGMPFYLPKGQIIRNELEAFLREIQKEYNYQEVRTPFMMNQEVWERSGHWGHYKDNM
YFSEVDNKSFALKPMNCPGHMLMFKNKLHSYRELPIRMCEFGQVHRHEFSGALNGLLRVRTFCQDDAHLFVTPEQIEDEI
KSVMAQIDYVYKTFGFEYEVELSTRPEDSMGDDKLWEQAEASLENVLQSLNYKYRLNEGDGAFYGPKIDFHIKDALNRSH
QCGTIQLDFQMPEKFDLNYIDEKNEKKRPVVIHRAVLGSLDRFLAILIEHFGGAFPAWVAPVQVKVIPVSNAVHVQYADE
VADKLAQAGVRVERDMRDEKLGYKIREAQMQKVPYVLVIGDKEMENGAVNVRKYGEEKSGVIELDMFVESMKEEIKNRK
>Mature_639_residues
MKEQMIEIKFPDGSVKEFVKGITLEEIAGSISSSLKKKAVAGKVNDELYDLRRNIEENAEVEIITIDSNEGVEIARHSAA
HILAQAVKRLYGDINLGVGPVIENGFYYDMDFPSSVNVEDLRKIEKEMKKIINENIKIERVEVSREEAAKLFQEMNDRLK
LELLEAIPSGESVTLYKQGEFVDLCRGPHLPSTGYLKAFQLTHVSGAYWRGDSNNQVLQRIYGVAFSSQKELEEYLHFVE
EAAKRNHRKLGNELELFMFSEEAPGMPFYLPKGQIIRNELEAFLREIQKEYNYQEVRTPFMMNQEVWERSGHWGHYKDNM
YFSEVDNKSFALKPMNCPGHMLMFKNKLHSYRELPIRMCEFGQVHRHEFSGALNGLLRVRTFCQDDAHLFVTPEQIEDEI
KSVMAQIDYVYKTFGFEYEVELSTRPEDSMGDDKLWEQAEASLENVLQSLNYKYRLNEGDGAFYGPKIDFHIKDALNRSH
QCGTIQLDFQMPEKFDLNYIDEKNEKKRPVVIHRAVLGSLDRFLAILIEHFGGAFPAWVAPVQVKVIPVSNAVHVQYADE
VADKLAQAGVRVERDMRDEKLGYKIREAQMQKVPYVLVIGDKEMENGAVNVRKYGEEKSGVIELDMFVESMKEEIKNRK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=638, Percent_Identity=43.730407523511, Blast_Score=556, Evalue=1e-158,
Organism=Homo sapiens, GI38202255, Length=611, Percent_Identity=45.4991816693944, Blast_Score=554, Evalue=1e-157,
Organism=Homo sapiens, GI20070344, Length=656, Percent_Identity=39.6341463414634, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=46.5408805031447, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=44.5324881141046, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=44.5324881141046, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322112, Length=627, Percent_Identity=43.859649122807, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=41.4141414141414, Blast_Score=320, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24583839, Length=635, Percent_Identity=43.6220472440945, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24583842, Length=635, Percent_Identity=43.6220472440945, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI28574141, Length=635, Percent_Identity=43.6220472440945, Blast_Score=560, Evalue=1e-159,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73754; Mature: 73754

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQMIEIKFPDGSVKEFVKGITLEEIAGSISSSLKKKAVAGKVNDELYDLRRNIEENAE
CCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
VEIITIDSNEGVEIARHSAAHILAQAVKRLYGDINLGVGPVIENGFYYDMDFPSSVNVED
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCHHH
LRKIEKEMKKIINENIKIERVEVSREEAAKLFQEMNDRLKLELLEAIPSGESVTLYKQGE
HHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
FVDLCRGPHLPSTGYLKAFQLTHVSGAYWRGDSNNQVLQRIYGVAFSSQKELEEYLHFVE
CHHHHCCCCCCCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
EAAKRNHRKLGNELELFMFSEEAPGMPFYLPKGQIIRNELEAFLREIQKEYNYQEVRTPF
HHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCCH
MMNQEVWERSGHWGHYKDNMYFSEVDNKSFALKPMNCPGHMLMFKNKLHSYRELPIRMCE
HCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHH
FGQVHRHEFSGALNGLLRVRTFCQDDAHLFVTPEQIEDEIKSVMAQIDYVYKTFGFEYEV
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ELSTRPEDSMGDDKLWEQAEASLENVLQSLNYKYRLNEGDGAFYGPKIDFHIKDALNRSH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEEHHHCCCCC
QCGTIQLDFQMPEKFDLNYIDEKNEKKRPVVIHRAVLGSLDRFLAILIEHFGGAFPAWVA
CCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCC
PVQVKVIPVSNAVHVQYADEVADKLAQAGVRVERDMRDEKLGYKIREAQMQKVPYVLVIG
CEEEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHCCHHHHHHHHHCCEEEEEC
DKEMENGAVNVRKYGEEKSGVIELDMFVESMKEEIKNRK
CCCCCCCCEEHHHCCCCCCCEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEQMIEIKFPDGSVKEFVKGITLEEIAGSISSSLKKKAVAGKVNDELYDLRRNIEENAE
CCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
VEIITIDSNEGVEIARHSAAHILAQAVKRLYGDINLGVGPVIENGFYYDMDFPSSVNVED
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCHHH
LRKIEKEMKKIINENIKIERVEVSREEAAKLFQEMNDRLKLELLEAIPSGESVTLYKQGE
HHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
FVDLCRGPHLPSTGYLKAFQLTHVSGAYWRGDSNNQVLQRIYGVAFSSQKELEEYLHFVE
CHHHHCCCCCCCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
EAAKRNHRKLGNELELFMFSEEAPGMPFYLPKGQIIRNELEAFLREIQKEYNYQEVRTPF
HHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCCH
MMNQEVWERSGHWGHYKDNMYFSEVDNKSFALKPMNCPGHMLMFKNKLHSYRELPIRMCE
HCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHH
FGQVHRHEFSGALNGLLRVRTFCQDDAHLFVTPEQIEDEIKSVMAQIDYVYKTFGFEYEV
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ELSTRPEDSMGDDKLWEQAEASLENVLQSLNYKYRLNEGDGAFYGPKIDFHIKDALNRSH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEEHHHCCCCC
QCGTIQLDFQMPEKFDLNYIDEKNEKKRPVVIHRAVLGSLDRFLAILIEHFGGAFPAWVA
CCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCC
PVQVKVIPVSNAVHVQYADEVADKLAQAGVRVERDMRDEKLGYKIREAQMQKVPYVLVIG
CEEEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHCCHHHHHHHHHCCEEEEEC
DKEMENGAVNVRKYGEEKSGVIELDMFVESMKEEIKNRK
CCCCCCCCEEHHHCCCCCCCEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2115870; 9384377; 9353933; 1379177 [H]