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The map label for this gene is pip [H]

Identifier: 118477648

GI number: 118477648

Start: 2130946

End: 2131857

Strand: Direct

Name: pip [H]

Synonym: BALH_1978

Alternate gene names: 118477648

Gene position: 2130946-2131857 (Clockwise)

Preceding gene: 118477647

Following gene: 118477651

Centisome position: 40.53

GC content: 33.0

Gene sequence:

>912_bases
ATGTTTATGGCCGATTTGATAGAAACAGGGAAATACATGAATATTAGAGGGAAAAAGCTATACGTTGAAACGCATGGAGA
TCCTAAAAATAAACCAGTTCTATACTTGCATGGTGGACCGGGAGAAAGTTGCTATGATTTTTCATTTCATCAAGCGGAAC
GTTTAAAAGATTCTTTATATGTAATTATGATAGATCAAAGAGGTGTTTGTCGCTCAGAAGAAATTACTGAAGACGAAGCT
TTTGGATTAAATGATTTGATTGAAGACTGTGAGGAATTAAAAAAAGTATTACAAATTAAGAAGTGGTCTATAATTGGACA
CTCTTTCGGTGGATATTTAGCATTGCTATATGCGTCGATATATCCAGGTTCAATAAAGAAAATAATATTTGAAGGACCAA
CTTTTGATTTTGCATTAACAAGCAGGGCTTTGTTGCAAAAGACAGGGCATTTATTAAAAAAGTATGGAAAAGAAGAAGTA
GCAGAAGAATCTCTTGCTTATTCATCTAGCAATGCGAGTTCAGAAGAGTTGCTAGAAGCTTATATAAGACTAAGTGATGA
ACTAGAAGAAAAAAGAATGGAGATTTACAATTATAAGGAAGATGGGACAGATGAGAGTTTATATAGTGATGAAGAGTGGG
AAGTATTTTCAAATCGCTCCAAGATCCATTTTGATAGATTAAAATTAGAGGGAGCATGTCATACGTCATTATTATCTAAA
ATAAAAGATGTACAGAATCCAATGTTATTAATAGTAGGAAAACATGATGTAGTAACGTGTGAAAAACAAATTGAAATATT
TAATAAAGATGCTCGAAACGGCAAGTATATCGTATTTGAAGAGAGCGGTCATTCACCTCATTATGAGGAAGCAGATAGAT
TCGCAGAAACAGTCATACATTTTTTGAAATGA

Upstream 100 bases:

>100_bases
TTTACTTCGATTTGTAGCGCCGCTCGCAATAATTATCGTCTTTTTAAATGTAATAGGGGTTATTTAAGAATAAATGTTAT
AATATTCAGTAAAAAAGGCG

Downstream 100 bases:

>100_bases
AGAAAAGGGTGCTTCTCTTAATAAGAAGCATCCTTTCTAAATTTCTGGATATGTGATTGTAATGCTAGGCCACTTACTTT
GCCAATTCTTTTTAATAACT

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MFMADLIETGKYMNIRGKKLYVETHGDPKNKPVLYLHGGPGESCYDFSFHQAERLKDSLYVIMIDQRGVCRSEEITEDEA
FGLNDLIEDCEELKKVLQIKKWSIIGHSFGGYLALLYASIYPGSIKKIIFEGPTFDFALTSRALLQKTGHLLKKYGKEEV
AEESLAYSSSNASSEELLEAYIRLSDELEEKRMEIYNYKEDGTDESLYSDEEWEVFSNRSKIHFDRLKLEGACHTSLLSK
IKDVQNPMLLIVGKHDVVTCEKQIEIFNKDARNGKYIVFEESGHSPHYEEADRFAETVIHFLK

Sequences:

>Translated_303_residues
MFMADLIETGKYMNIRGKKLYVETHGDPKNKPVLYLHGGPGESCYDFSFHQAERLKDSLYVIMIDQRGVCRSEEITEDEA
FGLNDLIEDCEELKKVLQIKKWSIIGHSFGGYLALLYASIYPGSIKKIIFEGPTFDFALTSRALLQKTGHLLKKYGKEEV
AEESLAYSSSNASSEELLEAYIRLSDELEEKRMEIYNYKEDGTDESLYSDEEWEVFSNRSKIHFDRLKLEGACHTSLLSK
IKDVQNPMLLIVGKHDVVTCEKQIEIFNKDARNGKYIVFEESGHSPHYEEADRFAETVIHFLK
>Mature_303_residues
MFMADLIETGKYMNIRGKKLYVETHGDPKNKPVLYLHGGPGESCYDFSFHQAERLKDSLYVIMIDQRGVCRSEEITEDEA
FGLNDLIEDCEELKKVLQIKKWSIIGHSFGGYLALLYASIYPGSIKKIIFEGPTFDFALTSRALLQKTGHLLKKYGKEEV
AEESLAYSSSNASSEELLEAYIRLSDELEEKRMEIYNYKEDGTDESLYSDEEWEVFSNRSKIHFDRLKLEGACHTSLLSK
IKDVQNPMLLIVGKHDVVTCEKQIEIFNKDARNGKYIVFEESGHSPHYEEADRFAETVIHFLK

Specific function: Releases the N-terminal proline from the dipeptides, Pro-Pro, Pro-Gln, Pro-Trp and Pro-Tyr. Also from amides (Pro-beta NA) and oligopeptides, Pro-Leu-GlyNH2, Pro-Leu-Gly and Pro-Phe- Gly-Lys. Higher activity toward small peptides (up to three residues), b

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34842; Mature: 34842

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMADLIETGKYMNIRGKKLYVETHGDPKNKPVLYLHGGPGESCYDFSFHQAERLKDSLY
CCHHHHHHCCCEEEECCCEEEEEECCCCCCCCEEEEECCCCCCEECCCHHHHHHHCCCEE
VIMIDQRGVCRSEEITEDEAFGLNDLIEDCEELKKVLQIKKWSIIGHSFGGYLALLYASI
EEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
YPGSIKKIIFEGPTFDFALTSRALLQKTGHLLKKYGKEEVAEESLAYSSSNASSEELLEA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHH
YIRLSDELEEKRMEIYNYKEDGTDESLYSDEEWEVFSNRSKIHFDRLKLEGACHTSLLSK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCEEEEHEEECCCHHHHHHHH
IKDVQNPMLLIVGKHDVVTCEKQIEIFNKDARNGKYIVFEESGHSPHYEEADRFAETVIH
HHHHCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FLK
HHC
>Mature Secondary Structure
MFMADLIETGKYMNIRGKKLYVETHGDPKNKPVLYLHGGPGESCYDFSFHQAERLKDSLY
CCHHHHHHCCCEEEECCCEEEEEECCCCCCCCEEEEECCCCCCEECCCHHHHHHHCCCEE
VIMIDQRGVCRSEEITEDEAFGLNDLIEDCEELKKVLQIKKWSIIGHSFGGYLALLYASI
EEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
YPGSIKKIIFEGPTFDFALTSRALLQKTGHLLKKYGKEEVAEESLAYSSSNASSEELLEA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHH
YIRLSDELEEKRMEIYNYKEDGTDESLYSDEEWEVFSNRSKIHFDRLKLEGACHTSLLSK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCEEEEHEEECCCHHHHHHHH
IKDVQNPMLLIVGKHDVVTCEKQIEIFNKDARNGKYIVFEESGHSPHYEEADRFAETVIH
HHHHCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FLK
HHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459939 [H]