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The map label for this gene is sirC [H]

Identifier: 118477575

GI number: 118477575

Start: 2051176

End: 2051655

Strand: Reverse

Name: sirC [H]

Synonym: BALH_1903

Alternate gene names: 118477575

Gene position: 2051655-2051176 (Counterclockwise)

Preceding gene: 118477576

Following gene: 118477566

Centisome position: 39.03

GC content: 36.04

Gene sequence:

>480_bases
ATGTGTATGTATAACATGTACCCTCTTATGTTTAATCTACATAATAAAGTGGTCGTTATCATTGGTGGAGGTAAAATCGC
ATATCGAAAAGCGTCTGGATTAAAAGATACAGGCGCTTTTGTCACCGTTGTCAGCCCAGAAATTTGCAAGGAAATGAAGG
AACTTCCTTATATTACTTGGAAGCAAAAAACTTTTAGTAATGATGATATTAAAGATGCTCATCTTATTTATGCAGCTACA
AATCAACATGCTGTAAATATGATGGTCAAACAGGCCGCCCATGATTTTCAATGGGTTAACGTTGTAAGTGACGGTACAGA
ATCATCGTTTCACACACCGGGTGTCATCCGAAATGGTGAATATGTTGTAACGATTTCAACTTCAGGTAAAGATCCATCTT
TTACGAAGCGTATGAAGCAGGAACTAACATCTATTTTTCCTACTCTTATAAAAAAGCTTTCTCGTACTCACAAATTATAA

Upstream 100 bases:

>100_bases
ATTAAGTTTCATACAAAAAAATACGATCACGTTACAACTTGTAACTGTCTTCAGTTTGATACATATATGAAATTAACATT
ACTAGAACGAATGGAGGAAT

Downstream 100 bases:

>100_bases
TCTATTTCTTAGCTAAAATAGTAATTACCTTTGGACGAACGTTTTTTAGAAGCGTTTGTTCTTTTGGTTTTGGTTTCTTT
TTTGAATTAAGCCGCTTGAT

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MCMYNMYPLMFNLHNKVVVIIGGGKIAYRKASGLKDTGAFVTVVSPEICKEMKELPYITWKQKTFSNDDIKDAHLIYAAT
NQHAVNMMVKQAAHDFQWVNVVSDGTESSFHTPGVIRNGEYVVTISTSGKDPSFTKRMKQELTSIFPTLIKKLSRTHKL

Sequences:

>Translated_159_residues
MCMYNMYPLMFNLHNKVVVIIGGGKIAYRKASGLKDTGAFVTVVSPEICKEMKELPYITWKQKTFSNDDIKDAHLIYAAT
NQHAVNMMVKQAAHDFQWVNVVSDGTESSFHTPGVIRNGEYVVTISTSGKDPSFTKRMKQELTSIFPTLIKKLSRTHKL
>Mature_159_residues
MCMYNMYPLMFNLHNKVVVIIGGGKIAYRKASGLKDTGAFVTVVSPEICKEMKELPYITWKQKTFSNDDIKDAHLIYAAT
NQHAVNMMVKQAAHDFQWVNVVSDGTESSFHTPGVIRNGEYVVTISTSGKDPSFTKRMKQELTSIFPTLIKKLSRTHKL

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis (Probable) [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=152, Percent_Identity=26.9736842105263, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 17947; Mature: 17947

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCMYNMYPLMFNLHNKVVVIIGGGKIAYRKASGLKDTGAFVTVVSPEICKEMKELPYITW
CCEECCCCEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHCCCEEE
KQKTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHDFQWVNVVSDGTESSFHTPGVIRNGE
ECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCC
YVVTISTSGKDPSFTKRMKQELTSIFPTLIKKLSRTHKL
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCMYNMYPLMFNLHNKVVVIIGGGKIAYRKASGLKDTGAFVTVVSPEICKEMKELPYITW
CCEECCCCEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHCCCEEE
KQKTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHDFQWVNVVSDGTESSFHTPGVIRNGE
ECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCC
YVVTISTSGKDPSFTKRMKQELTSIFPTLIKKLSRTHKL
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10217486 [H]