Click here to switch to the map view.

The map label for this gene is 118477513

Identifier: 118477513

GI number: 118477513

Start: 1990708

End: 1991247

Strand: Direct

Name: 118477513

Synonym: BALH_1838

Alternate gene names: NA

Gene position: 1990708-1991247 (Clockwise)

Preceding gene: 118477512

Following gene: 118477514

Centisome position: 37.87

GC content: 37.22

Gene sequence:

>540_bases
ATGTCTAAAACATTGCAATCTTTTAATTTACTAAAATGGATTGATGAGAATAAGGAGTTATTGAAGCCACCAGTAAATAA
CAAAGTTATTTGGCAAGATTCAGAGTTTATCGCCATGATATTAGGTGGTCCAAATAGAAGACGTGATTTCCACGTAGATC
CTTCAGATGAATTTTTCTATCAAATTAAAGGTGAATGTTATGTGGAATGTATTACAGAAGAAGGGAAGCGGGAAGTCGTC
ACAGTAAAAGAAGGGGATGTATTTATGCTACCAGCTATGGTACCGCATTCACCACATCGCGTTGCTAACACATATGGGCT
CGTAATTGAAAGAAAACGTAGCCAAGGAGAACTTGAGGATTTCGTTTGGTTCTGTGATGAGTGTAATCATGAAATGCATC
GTGTACGCGTCCAATTAAGTGACATTGAAAAACAAGTAAAAGAAGCGATTCATAGTTTTAATTCAAATAAAGAAATTCGA
GCATGTAAAAACTGCGGTCATATTATGCCAGAGGAAGTGGGGGAATGGAAGTGCGAATAG

Upstream 100 bases:

>100_bases
GAGATTATGTCTATCATGGGGATTTGCAAAAGTCTAGTTCTTTACTCGGTTGGTCTTTTAAAACGATATAAATAAAAAGG
AATTATAAGGAGGAAATAGT

Downstream 100 bases:

>100_bases
ATTTTCATACACATATTATTCCTGAAACTTTTCCAGATTTTGAAGAGAAGTTTGGTGGCGGTCGTTGGCCGATATTAAAT
CGGACTTGTACATGTGGTGC

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSKTLQSFNLLKWIDENKELLKPPVNNKVIWQDSEFIAMILGGPNRRRDFHVDPSDEFFYQIKGECYVECITEEGKREVV
TVKEGDVFMLPAMVPHSPHRVANTYGLVIERKRSQGELEDFVWFCDECNHEMHRVRVQLSDIEKQVKEAIHSFNSNKEIR
ACKNCGHIMPEEVGEWKCE

Sequences:

>Translated_179_residues
MSKTLQSFNLLKWIDENKELLKPPVNNKVIWQDSEFIAMILGGPNRRRDFHVDPSDEFFYQIKGECYVECITEEGKREVV
TVKEGDVFMLPAMVPHSPHRVANTYGLVIERKRSQGELEDFVWFCDECNHEMHRVRVQLSDIEKQVKEAIHSFNSNKEIR
ACKNCGHIMPEEVGEWKCE
>Mature_178_residues
SKTLQSFNLLKWIDENKELLKPPVNNKVIWQDSEFIAMILGGPNRRRDFHVDPSDEFFYQIKGECYVECITEEGKREVVT
VKEGDVFMLPAMVPHSPHRVANTYGLVIERKRSQGELEDFVWFCDECNHEMHRVRVQLSDIEKQVKEAIHSFNSNKEIRA
CKNCGHIMPEEVGEWKCE

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family

Homologues:

Organism=Homo sapiens, GI188497625, Length=151, Percent_Identity=36.4238410596026, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562218, Length=159, Percent_Identity=34.5911949685535, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322485, Length=161, Percent_Identity=42.2360248447205, Blast_Score=138, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3HAO_BACAH (A0RD64)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_894664.1
- ProteinModelPortal:   A0RD64
- SMR:   A0RD64
- STRING:   A0RD64
- EnsemblBacteria:   EBBACT00000068982
- GeneID:   4545488
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_1838
- NMPDR:   fig|412694.5.peg.1824
- eggNOG:   NOG77058
- GeneTree:   EBGT00050000005165
- HOGENOM:   HBG341987
- OMA:   LKPPVNN
- ProtClustDB:   PRK13264
- BioCyc:   BTHU412694:BALH_1838-MONOMER
- HAMAP:   MF_00825
- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- TIGRFAMs:   TIGR03037

Pfam domain/function: PF06052 3-HAO; SSF51182 RmlC_like_cupin

EC number: =1.13.11.6

Molecular weight: Translated: 20985; Mature: 20854

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: BINDING 47-47 BINDING 57-57 BINDING 100-100 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTLQSFNLLKWIDENKELLKPPVNNKVIWQDSEFIAMILGGPNRRRDFHVDPSDEFFY
CCCCHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCEECCCCCCEEE
QIKGECYVECITEEGKREVVTVKEGDVFMLPAMVPHSPHRVANTYGLVIERKRSQGELED
EECCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCHHHHEEEEEEEECCCCCCHHH
FVWFCDECNHEMHRVRVQLSDIEKQVKEAIHSFNSNKEIRACKNCGHIMPEEVGEWKCE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SKTLQSFNLLKWIDENKELLKPPVNNKVIWQDSEFIAMILGGPNRRRDFHVDPSDEFFY
CCCHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCEECCCCCCEEE
QIKGECYVECITEEGKREVVTVKEGDVFMLPAMVPHSPHRVANTYGLVIERKRSQGELED
EECCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCHHHHEEEEEEEECCCCCCHHH
FVWFCDECNHEMHRVRVQLSDIEKQVKEAIHSFNSNKEIRACKNCGHIMPEEVGEWKCE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA