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The map label for this gene is mdmC [H]

Identifier: 118477416

GI number: 118477416

Start: 1891207

End: 1891911

Strand: Direct

Name: mdmC [H]

Synonym: BALH_1736

Alternate gene names: 118477416

Gene position: 1891207-1891911 (Clockwise)

Preceding gene: 118477415

Following gene: 118477417

Centisome position: 35.97

GC content: 38.58

Gene sequence:

>705_bases
ATGCATTGGAAAATTGAAGGGGATGGTATTTACATGAGTACGATTGAGAAATGGACGGCTGTTGATCAATATGTGAGTGA
CATATTAATACCGAAAGATTCTACATTAGAAGAAGTACTTCAAACTAATGCTACAGCTAATTTACCAGCACATGATGTAT
CGCCAACGCAAGGGATGTTTTTACAACTATTAGTACAAATTCAAGGAGCTCGTAACATTTTAGAAATTGGTACTCTAGGT
GGGTATAGCACGATATGGCTTGCAAGGAGTTTGCCACCTGAAGGACGAGTTGTTACATTAGAAGCAAATGAAAAGCATGC
TGACATTGCGCGTAGCAATATTGAACGCGCTAATTTGAATGATAGAATTGAAGTGCGAACAGGATTTGCTTTAGATTCTT
TAAAGCAAATCGAAAATGAGAAGTATGAACCCTTTGACTTTATTTTTATAGACGCTGATAAACAAAATAACCCAGCTTAT
TTTGAATGGGCACTGAAACTATCACGTCCTGGTACTGTAATCATTGGAGATAACGTAGTACGTGAAGGAGAAGTTATTGA
CAATACGAGTAATGACCCTCGCGTACAAGGGATACGTCGTTTCTATGAATTAATAGCTACTGAGCCGCGTGTAAGTGCTA
CAGCGCTTCAAACGGTGGGTAGTAAAGGGTACGATGGATTTATAATGGCGGTCGTAAAAGAATAA

Upstream 100 bases:

>100_bases
CAAAAGAAGGGATATCTATTTTGTAATGAAATAGATGTCCCTTCTTTATTTTTTGTATATGAGACAGAATTTTCGGTATA
ATTGAAAGCGAATAGTAGAA

Downstream 100 bases:

>100_bases
CGAAAGGAGATAAATAGAATGAAAAAGATGTTTGAAAAATTATAACATGTATCGTGTATAACGAGATTAGCTCGTGGACC
TCCAGTTATACATAGCACTA

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MHWKIEGDGIYMSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANLPAHDVSPTQGMFLQLLVQIQGARNILEIGTLG
GYSTIWLARSLPPEGRVVTLEANEKHADIARSNIERANLNDRIEVRTGFALDSLKQIENEKYEPFDFIFIDADKQNNPAY
FEWALKLSRPGTVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE

Sequences:

>Translated_234_residues
MHWKIEGDGIYMSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANLPAHDVSPTQGMFLQLLVQIQGARNILEIGTLG
GYSTIWLARSLPPEGRVVTLEANEKHADIARSNIERANLNDRIEVRTGFALDSLKQIENEKYEPFDFIFIDADKQNNPAY
FEWALKLSRPGTVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
>Mature_234_residues
MHWKIEGDGIYMSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANLPAHDVSPTQGMFLQLLVQIQGARNILEIGTLG
GYSTIWLARSLPPEGRVVTLEANEKHADIARSNIERANLNDRIEVRTGFALDSLKQIENEKYEPFDFIFIDADKQNNPAY
FEWALKLSRPGTVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=205, Percent_Identity=29.2682926829268, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=207, Percent_Identity=29.951690821256, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565612, Length=206, Percent_Identity=30.5825242718447, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 26212; Mature: 26212

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWKIEGDGIYMSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANLPAHDVSPTQGMF
CEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHH
LQLLVQIQGARNILEIGTLGGYSTIWLARSLPPEGRVVTLEANEKHADIARSNIERANLN
HHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCCCC
DRIEVRTGFALDSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVV
CEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCEE
REGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
ECCCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure
MHWKIEGDGIYMSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANLPAHDVSPTQGMF
CEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHH
LQLLVQIQGARNILEIGTLGGYSTIWLARSLPPEGRVVTLEANEKHADIARSNIERANLN
HHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCCCC
DRIEVRTGFALDSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVV
CEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCEE
REGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
ECCCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]