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The map label for this gene is pdp [H]

Identifier: 118477357

GI number: 118477357

Start: 1826867

End: 1828180

Strand: Direct

Name: pdp [H]

Synonym: BALH_1676

Alternate gene names: 118477357

Gene position: 1826867-1828180 (Clockwise)

Preceding gene: 118477356

Following gene: 118477358

Centisome position: 34.75

GC content: 37.37

Gene sequence:

>1314_bases
ATGGTGATTGTAATGAGAATGGTAGATATTATTGCGAAAAAACGTGACGGTAAAGAATTAACAACTGAAGAAATCAAATT
CTTTATTAATGGTTATACAGACGGAAGTATTCCTGATTATCAAGTAAGTGCACTTGCAATGGCAATCTTCTTTAAAGATA
TGACAGATCGCGAACGTGCAGATTTAACGATGGCAATGGTGGAGTCTGGAGAAACAATCGACTTATCTGCAATTGAAGGA
ATTAAAGTAGACAAACATTCAACTGGTGGTGTTGGTGATACAACAACATTAGTATTAGGACCATTAGTAGCTGCTTTAGA
TGTACCAGTAGCAAAAATGTCTGGTCGTGGTTTAGGACATACAGGCGGAACAATTGATAAATTAGAAGCGGTAGAAGGAT
TCCACGTTGAAATTACGAAAGAGCAGTTCATTGATATTGTAAACCGTGACAAAGTAGCTGTTATTGGACAAACAGGAAAC
TTAACACCTGCAGATAAAAAGATTTATGCATTACGCGATGTAACAGGAACTGTTAACTCAATTCCTCTAATTGCAAGTTC
AATTATGAGTAAAAAAATTGCAGCAGGTGCTGACGCAATCGTACTTGATGTAAAAACAGGTGCTGGCGCGTTTATGAAAA
CAGAAGAAGATGCAAAAGAATTAGCACATGCAATGGTACGTATCGGAAATAATGTAGGACGTCAAACTATGGCTGTTATT
TCAGATATGTCACAACCGCTTGGATTTGCGATTGGTAACGCTTTAGAAGTGAAAGAAGCAATCGATACGTTAAAAGGTGA
AGGTCCAGAAGATTTAACAGAATTAGTACTCGTATTAGGAAGTCAGATGGTTGTACTTGCGAAAAAAGCAAATACATTAG
AAGAAGCGCGTGAAATGTTAATTGAAGTGATGAAGAACGGAAAAGCAACTGAGAAGTTTAAAGAGTTCTTAAACAATCAA
GGTGGAGATAGCTCAATTGTAGACAATCCAGAAAAAATGCCACAGGCGAAGTATGTAATTGATGTACCTGCTAAAACTTC
AGGTGTTATTTCTAACATTGTTGCAGATGAAATCGGTATCGCAGCTATGTTACTTGGCGCTGGCCGTGCAACAAAAGAAG
ATGAAATTGATTTAGCGGTAGGGTTAATGTTACGTAAAAAAGTGGGCGATGCAGTAAAAGAAGGCGAACCATTCGTAACG
ATTTATGCAAACCGTGAAAATGTAGAAGATGTAAAAGCTAAAATCTATGAGAACATTTCAATCGCTGAAACAGCAGTGGC
TCCTAAATTGGTTCATACAGTGATTACTGACTAA

Upstream 100 bases:

>100_bases
ATTTGGTTTGAAGTTGCTTTTCGGTGCAACATTAGTAAGTTTCTTATCAGCAACAATCGTAGGCTTATTATTTTAATAGA
TTCATATCATATAAAAAGGA

Downstream 100 bases:

>100_bases
TCAACATTACACTTACTTTGAGGAGGAAATAATATGGATAAGAAAAAATATATTGAAGAAGCAAATAAGATGTTAGCAAA
AGCATATATTCCGTATTCAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MVIVMRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEG
IKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGN
LTPADKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVI
SDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLNNQ
GGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVT
IYANRENVEDVKAKIYENISIAETAVAPKLVHTVITD

Sequences:

>Translated_437_residues
MVIVMRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEG
IKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGN
LTPADKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVI
SDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLNNQ
GGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVT
IYANRENVEDVKAKIYENISIAETAVAPKLVHTVITD
>Mature_437_residues
MVIVMRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEG
IKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGN
LTPADKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVI
SDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLNNQ
GGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVT
IYANRENVEDVKAKIYENISIAETAVAPKLVHTVITD

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI4503445, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI166158922, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=46.7821782178218, Blast_Score=338, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46765; Mature: 46765

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIVMRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERA
CEEHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
DLTMAMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGH
HEEHEECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCC
TGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNS
CCCCHHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHH
IPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHH
SDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREML
HHHCCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHH
IEVMKNGKATEKFKEFLNNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGI
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
AAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENIS
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCC
IAETAVAPKLVHTVITD
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVIVMRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERA
CEEHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
DLTMAMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGH
HEEHEECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCC
TGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNS
CCCCHHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHH
IPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHH
SDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREML
HHHCCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHH
IEVMKNGKATEKFKEFLNNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGI
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
AAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENIS
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCC
IAETAVAPKLVHTVITD
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]