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The map label for this gene is mntH [H]

Identifier: 118477340

GI number: 118477340

Start: 1804436

End: 1805731

Strand: Reverse

Name: mntH [H]

Synonym: BALH_1657

Alternate gene names: 118477340

Gene position: 1805731-1804436 (Counterclockwise)

Preceding gene: 118477342

Following gene: 118477335

Centisome position: 34.35

GC content: 37.35

Gene sequence:

>1296_bases
ATGAATAAAGATATATCAAAAGATGAACAAGTCCCTTCTCAAAGTACAACTGTTCAATCAGCACATTTAGCATTAAGCGG
ACAAACGAAAGGTTTAAAAAGACTATTACCTTTTTTAGGTCCTGCTTTTATCGCTTCAGTCGCTTATATTGATCCTGGCA
ATTTCGCGACAAATATTGCCGCTGGATCACAATATGGATATTTATTACTCTGGGTAATTCTCGCTTCTAATTTAATGGCT
GTATTAATCCAAACTTTATCAGCTAAATTAGGAATCGCTACAGGTAGAAACCTTCCTGAAATTGCTCGAGAAAACTTCCC
AAAACCTGTATCCATCGGCTTATGGATACAAGGTGAACTCGTTATTATGGCTACTGATTTAGCTGAATTTATCGGGGCAG
CACTCGGATTGTATTTATTATTTGGAATTCCGATGCTACCTGCCGCTTTAATTACAGCAGTCGGATCATTTATTATTCTT
GAGTTTCAACGAAGAGGATTTCGCCCATTAGAAGCTATCATAACAGGAATGATTTTCATCGTTGTTATCGCTTTTGGTGT
ACAAGTCTTTTATGCAAAACCGGAATTAAGTCCTCTACTTTCAGGACTTTTCATTCCGAAATTCCAAGGTGTAGACAGTA
TATTACTTGCAGCCGGAATTTTAGGTGCGACAGTTATGCCACACGCAATCTATTTACATTCCGCCTTAACGCAGCGCCGC
GTAGTCGGAACAAATGATGAACAAAAGAAAAAGATTTTCCGCTTCGAGTTTATTGATATCATTATCGCAATGGTTATCGC
CGGAGCAATTAATGCAAGTATGTTAATTGTTGCTGCTGCACTATTCTTTAAAAACGGCTTGCATGTTGAAGATCTTGATG
TTGCTTTTAACCAGTTTAGTAACTTAGTCGGTCCTGTATCAGCTGCTTTATTTGGAATTGGTCTCTTATCAGCAGGGCTA
TCTAGCTCTTCTGTCGGTACAATGTCAGGTGATATTATTATGCAAGGTTTCATTCGAATGCATATTCCGTTATACTTACG
CCGCTTTATTACAATGATTCCACCATTAGTTATTATCGCTTTAGGTGTAAATCCAACTTACGCTCTAGTCATGAGCCAAG
TTGTCTTATCATTCGGTATTGCCTTTGCATTAGTACCACTTATTATGTTTACAAGTAGTAAAAAAATTATGGGTGCACTC
GTTAATCACCGCATAACTACCTTTATCGCTTGGATCATTGCTGTACTTGTTATCATTTTAAATATTTTCTTACTGTATCA
AACATTTGTAGGGTAA

Upstream 100 bases:

>100_bases
AAATAAAAATATCATCTAATACATTTAAATGTATTGAAATAAGCAATAAGAATACTTACAATAATTTCATCATGTTAACA
TTTTAAAGGGGAAAACGACT

Downstream 100 bases:

>100_bases
TGAAAGAAGAAGGCTGTCTCAAATTTCTGTTGAAGACAGCCTTCTTCTTTTTAAATTATAAATTTTTATCATCCATTTAC
ATGACAGACCGTGCTTTCAA

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNKDISKDEQVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAVGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGAL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG

Sequences:

>Translated_431_residues
MNKDISKDEQVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAVGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGAL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG
>Mature_431_residues
MNKDISKDEQVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAVGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGAL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=464, Percent_Identity=31.4655172413793, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI295293167, Length=436, Percent_Identity=32.1100917431193, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI295293178, Length=436, Percent_Identity=32.1100917431193, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI295293171, Length=436, Percent_Identity=32.1100917431193, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI295293169, Length=436, Percent_Identity=32.1100917431193, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI295293175, Length=436, Percent_Identity=32.1100917431193, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI295293173, Length=436, Percent_Identity=32.1100917431193, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI10835169, Length=436, Percent_Identity=32.1100917431193, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=51, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI193210616, Length=465, Percent_Identity=29.8924731182796, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17569473, Length=395, Percent_Identity=33.4177215189873, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71999499, Length=465, Percent_Identity=29.0322580645161, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993856, Length=242, Percent_Identity=33.0578512396694, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321841, Length=415, Percent_Identity=34.6987951807229, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323062, Length=397, Percent_Identity=32.4937027707809, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324450, Length=426, Percent_Identity=32.6291079812207, Blast_Score=179, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24648607, Length=443, Percent_Identity=30.0225733634311, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI281362176, Length=443, Percent_Identity=30.0225733634311, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24648609, Length=443, Percent_Identity=30.0225733634311, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI45553443, Length=421, Percent_Identity=30.8788598574822, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46469; Mature: 46469

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDISKDEQVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCHHCCCCCCCHHHHHHEEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGRNLPEIARENFPKPVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAVGSFIILEFQRRGFRPLEAIITGMIFI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVGTNDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGALVNHRITTFIAWIIAVLVIIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC
>Mature Secondary Structure
MNKDISKDEQVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCHHCCCCCCCHHHHHHEEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGRNLPEIARENFPKPVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAVGSFIILEFQRRGFRPLEAIITGMIFI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVGTNDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGALVNHRITTFIAWIIAVLVIIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146 [H]