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The map label for this gene is glcD [H]

Identifier: 118476870

GI number: 118476870

Start: 1316067

End: 1317479

Strand: Reverse

Name: glcD [H]

Synonym: BALH_1159

Alternate gene names: 118476870

Gene position: 1317479-1316067 (Counterclockwise)

Preceding gene: 118476871

Following gene: 118476869

Centisome position: 25.06

GC content: 39.42

Gene sequence:

>1413_bases
ATGTTAGAAAAGCAAATTATTGATTCATTCGTATCCATTGTTGGCGAAGATAATGTAGATACATCCAATATGGGGCGTTT
AACGTATAGTTATGATGCCACTCCAAACTTCCAAGCAATGCCTGATGCAGTCATTGCTCCTCGTAATACAAATGAAGTAG
CAGAAGTGTTAAAAGTATGTAACACTCACAACATTCCTGTATATGTTCGTGGCTCTGGAACAAACCTTTGCGCAGGAACA
TGTCCACTTGAAGGCGGTATCGTCCTTATCTTCCGTCATATGAATAACATTTTAGAAATTGATGAAGAGAATTTAACAAT
CACAGTACAAGCTGGTGTGATTACGCTTGATATTATTAAAGCAGTAGAAGAAAAAGGTTTATTTTACCCACCGGATCCAA
GCTCAATGAAAATTTCTACAATTGGCGGTAACATTAATGAAAACTCAGGTGGCTTACGCGGATTAAAATATGGGGTAACA
CGTGATTATGTGATGGGTCTTGAACTTGTCTTACCAAATGGTGATATGATTCGCACTGGTGGTAAATTAGCAAAAGATGT
AGCTGGTTACGATCTAACTCGGTTATTTATCGGTTCTGAAGGAACACTTGGCGTCGTAACAGAAGCAATATTAAAACTTG
TTCCTATGCCTGAAACGAAGAAAACGATGCTTGCACTCTATGAAGATATTAATGAAGCTGCACGTGCTGTTTCTTCTATT
ATTGCAAATAAAATCATTCCAGCGACACTTGAGTTTTTAGACCAGCCGACAATTGAAGTAGTAGAAGAGTTTGCTCAAAT
CGGTTTACCAACTGACGTAAAAGCAATTTTATTAATTGAACAAGACGGTCCGCCTGAAGTTGTCAATCGAGATATTGAAA
AAATGGCTAATGTTTGTCGTTCTATGAATGCAGTTGATGTTCGCGTCGCAAAAGATGAAGCGGAAGCAGATGCGCTTCGA
ACAGCTCGCCGTAGTGCACTGTCAGCACTGGCAAGATTAAAACCTACTACAATATTAGAAGATGCAACGGTACCACGCTC
ACAAATCGCTCCGATGGTTGAAGCTATTAATGCCATTGCCAAAAAATATAATATTCCTATTTGTACGTTTGGGCATGCTG
GTGATGGTAACTTACATCCAACTTGTATGACAGATGCTCGCAACGAAGAAGAAATGCACAGAGCTGAACAAGCTTTCGCT
GAAATATTTGCGAAAGCAATTGAACTTGGTGGTACGATTACTGGTGAACATGGTGTTGGTGCGATGAAAGCTCCCTATTT
AGAAATGAAATTAGGTAAAGAAGGTATTGCTGCTATGCAAGGGATTAAACAAGCCTTCGATCCAAATAATATTATGAATC
CAGGAAAGATGTTCGCGAAGGACACTCGTAAAAGAGTGGTGGTTGAGCGATGA

Upstream 100 bases:

>100_bases
ATAGAAAGAATCCCCCGACTTTTTTATCATTATAATGAAAGCACTGTGACAACGTTTTTTATTATGACTCATTACGTTAA
CAGTTTGAGGGGGATTTCCA

Downstream 100 bases:

>100_bases
CAACATTAAATAAAGAAAACATTCAAAAAGAATTTAAAGAACGATTAAGTGAAGATGAACTACTAAACTGCATGCGATGC
GGTTTCTGTTTACCAACTTG

Product: (S)-2-hydroxy-acid oxidase, subunit D

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHNIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDMIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKQAFDPNNIMNPGKMFAKDTRKRVVVER

Sequences:

>Translated_470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHNIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDMIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKQAFDPNNIMNPGKMFAKDTRKRVVVER
>Mature_470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHNIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDMIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKQAFDPNNIMNPGKMFAKDTRKRVVVER

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=467, Percent_Identity=30.8351177730193, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI37595754, Length=490, Percent_Identity=29.3877551020408, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI119964728, Length=432, Percent_Identity=28.4722222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501993, Length=228, Percent_Identity=28.9473684210526, Blast_Score=116, Evalue=6e-26,
Organism=Escherichia coli, GI1789351, Length=430, Percent_Identity=38.1395348837209, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1787977, Length=512, Percent_Identity=27.34375, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI48994907, Length=484, Percent_Identity=25.6198347107438, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI48994914, Length=173, Percent_Identity=33.5260115606936, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=467, Percent_Identity=32.3340471092077, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71992381, Length=467, Percent_Identity=31.9057815845824, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=32.03125, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17534361, Length=465, Percent_Identity=28.8172043010753, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556096, Length=219, Percent_Identity=28.7671232876712, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320027, Length=445, Percent_Identity=31.0112359550562, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320764, Length=474, Percent_Identity=28.2700421940928, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320023, Length=453, Percent_Identity=28.0353200883002, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653753, Length=255, Percent_Identity=28.2352941176471, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50970; Mature: 50970

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVC
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHH
NTHNIPVYVRGSGTNLCAGTCPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIK
CCCCCEEEEECCCCCEEEECCCCCCCEEEEEEHHHHHEEECCCCEEEEEECCCHHHHHHH
AVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVTRDYVMGLELVLPNGDMIRTG
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCHHHHEEEEEEECCCCEEECC
GKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
CHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
SMNAVDVRVAKDEAEADALRTARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIA
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
KKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFAEIFAKAIELGGTITGEHGVG
HHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
AMKAPYLEMKLGKEGIAAMQGIKQAFDPNNIMNPGKMFAKDTRKRVVVER
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVC
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHH
NTHNIPVYVRGSGTNLCAGTCPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIK
CCCCCEEEEECCCCCEEEECCCCCCCEEEEEEHHHHHEEECCCCEEEEEECCCHHHHHHH
AVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVTRDYVMGLELVLPNGDMIRTG
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCHHHHEEEEEEECCCCEEECC
GKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
CHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
SMNAVDVRVAKDEAEADALRTARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIA
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
KKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFAEIFAKAIELGGTITGEHGVG
HHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
AMKAPYLEMKLGKEGIAAMQGIKQAFDPNNIMNPGKMFAKDTRKRVVVER
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]