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The map label for this gene is proY [H]

Identifier: 118476374

GI number: 118476374

Start: 733045

End: 734436

Strand: Reverse

Name: proY [H]

Synonym: BALH_0632

Alternate gene names: 118476374

Gene position: 734436-733045 (Counterclockwise)

Preceding gene: 118476377

Following gene: 118476373

Centisome position: 13.97

GC content: 38.22

Gene sequence:

>1392_bases
ATGCAACACTCAAACAAATCTGGAACTTTAAACCGCGGTTTAAAAGAACGACATATTACTTTAATGTCACTCGGTTCAGC
TATTGGCGTTGGACTATTTTTAGGATCTGCTTCTGCTATTAAACTAGCTGGGCCCTCTATTTTACTAGGATATATGATTG
CTGGACTCGTTATTTTTTTCATTATGCGAGCGCTCGGAGAAATGGCAATTGAACAACCTGTTGCCGGCTCTTTTAGTAAA
TATGCATATGATTATCTCGGACCGCTAGCTGGTTATATTACAGGTTGGAACTACTGGTTCTTATGGGTTGTTACTTGCAT
GGCTGAAATTACAGCAGCTGGCATTTACATGCAGTACTGGTTCCCGGATATTCCGCGTTGGACTTGGGCGCTACTCGCTT
TATTATTAATGAGCGCTTTCAACTTCTTATCCGTAAAAGTATTTGGAGAACTTGAATTTTGGTTTGCTCTCATTAAAATT
GTCACAATTATCTGTATGATAGTAGTTGGAGCTGGTATTATTTTATTCGGATTCGGAAATGGCGGAATAGCCACTGGTAT
TTCAAACCTTTGGTCACATGGTGGCTGGTTTCCAAATGGATTTTCTGGGTTACTACTCTCCATGCAAATGGTATTATTCG
CTTATTTAGGCGTTGAATTAATCGGTGTTACAGCTGGTGAAGCTCAAAACCCGAAAAAAACACTCGCAAAAGCAATCGAT
AACGTATTTTGGAGAATATTACTGTTCTACGTTGGAGCTCTATTCGTTATGATGGCAATTTATCCATGGAACGAACTGGG
TGAGAAAGGAAGTCCATTCGTATTAACATTTCAACAAATCGGTATTGCAAAAGCAGCAGGGATTATTAACTTTGTCGTAT
TAACAGCAGCTCTTTCATCTTGTAATGGTGGTTTATTTAGTACAGGCCGTATGCTATATACATTAGCTCAGCAAAAGAAA
GCACCTGAAAGATTCGGTCGTTTAAATAAAAATGGCATTCCAAGTCAAGGAATTGTAGCAACTGCGATCGTTTTACTCAT
TGGCGTTATATTAAACTATCTCGTACCAGCAAAGGTATTTACATGGCTCACTAGCATTTCAACTTTCGGAGCAATTTGGA
CTTGGGGCATTATATTAGTCGCTCAAATCAAGTTCCGTAAAAGTTTGCCTACGCAAAAGAGACAAAAGTTATCGTATAAA
ATGCCTTTATACCCATTAAGTTCATATTTCTCACTTGCTTTCCTTGTACTAGTATTAGGTATAATGGCGTATTCAGAAGA
TACACGAATTGCATTAATCGTCGGCCCTATTTGGCTTATCGGCTTAGCTATCGTGTACTACATGAAAGGGTTTCATAAAA
TTGATGAAACACCTAATTCAAAAATTAGTTAA

Upstream 100 bases:

>100_bases
TTTTGTAGCATAACAGATGGAAATGTTTTATAATTTGAAATAGTTAAATATTTAGTAAACGCATTCAAACATCGTTCACT
CTACAAGGGGGATTCTTCTT

Downstream 100 bases:

>100_bases
ACAAAACATCCCTTCCTTATTGATTGGAAGGGGTGTTTTTATGTCTATATAAATATTTCTCAACAAAATTCACGTTATTT
TTACAATTTTTTAATATTTT

Product: amino acid permease, proline-specific permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQHSNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLIGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQKRQKLSYK
MPLYPLSSYFSLAFLVLVLGIMAYSEDTRIALIVGPIWLIGLAIVYYMKGFHKIDETPNSKIS

Sequences:

>Translated_463_residues
MQHSNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLIGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQKRQKLSYK
MPLYPLSSYFSLAFLVLVLGIMAYSEDTRIALIVGPIWLIGLAIVYYMKGFHKIDETPNSKIS
>Mature_463_residues
MQHSNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLIGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQKRQKLSYK
MPLYPLSSYFSLAFLVLVLGIMAYSEDTRIALIVGPIWLIGLAIVYYMKGFHKIDETPNSKIS

Specific function: Probable Amino-Acid Or Metabolite Transport Protein. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=25.3405994550409, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258645169, Length=408, Percent_Identity=23.0392156862745, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4507047, Length=444, Percent_Identity=22.7477477477477, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258614003, Length=409, Percent_Identity=22.9828850855746, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI258614005, Length=409, Percent_Identity=22.9828850855746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI114326544, Length=430, Percent_Identity=21.8604651162791, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI114326550, Length=430, Percent_Identity=21.8604651162791, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI181337167, Length=319, Percent_Identity=23.1974921630094, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=49.0238611713666, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1786602, Length=460, Percent_Identity=51.9565217391304, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1786789, Length=443, Percent_Identity=45.1467268623025, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=45.4545454545455, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=44.1048034934498, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI87081915, Length=433, Percent_Identity=40.4157043879908, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI87081708, Length=467, Percent_Identity=37.6873661670236, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=36.117381489842, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788480, Length=441, Percent_Identity=37.6417233560091, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI87081869, Length=470, Percent_Identity=21.9148936170213, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367353, Length=341, Percent_Identity=23.4604105571848, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=366, Percent_Identity=23.224043715847, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=450, Percent_Identity=25.3333333333333, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=343, Percent_Identity=23.0320699708455, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=480, Percent_Identity=31.6666666666667, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322892, Length=433, Percent_Identity=33.256351039261, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=472, Percent_Identity=31.9915254237288, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=31.1659192825112, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324990, Length=440, Percent_Identity=31.1363636363636, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=30.9255079006772, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=27.3148148148148, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=409, Percent_Identity=28.6063569682152, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=436, Percent_Identity=27.7522935779816, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=30.8457711442786, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6320251, Length=430, Percent_Identity=28.3720930232558, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=473, Percent_Identity=27.6955602536998, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=411, Percent_Identity=27.4939172749392, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=25.9445843828715, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=412, Percent_Identity=26.6990291262136, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=403, Percent_Identity=25.8064516129032, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=432, Percent_Identity=26.1574074074074, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=25.5445544554455, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221512776, Length=424, Percent_Identity=20.7547169811321, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666159, Length=424, Percent_Identity=20.7547169811321, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668806, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356285, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24668802, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667468, Length=349, Percent_Identity=22.9226361031519, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077963, Length=368, Percent_Identity=23.6413043478261, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281366235, Length=368, Percent_Identity=25.5434782608696, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007820, Length=368, Percent_Identity=25.5434782608696, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007818, Length=338, Percent_Identity=26.0355029585799, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85725152, Length=338, Percent_Identity=26.0355029585799, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50908; Mature: 50908

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHSNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFF
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
IMRALGEMAIEQPVAGSFSKYAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKIVTIICMIVVGAGIILFGFGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSS
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
CNGGLFSTGRMLYTLAQQKKAPERFGRLNKNGIPSQGIVATAIVLLIGVILNYLVPAKVF
CCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TWLTSISTFGAIWTWGIILVAQIKFRKSLPTQKRQKLSYKMPLYPLSSYFSLAFLVLVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
IMAYSEDTRIALIVGPIWLIGLAIVYYMKGFHKIDETPNSKIS
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQHSNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFF
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
IMRALGEMAIEQPVAGSFSKYAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKIVTIICMIVVGAGIILFGFGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSS
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
CNGGLFSTGRMLYTLAQQKKAPERFGRLNKNGIPSQGIVATAIVLLIGVILNYLVPAKVF
CCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TWLTSISTFGAIWTWGIILVAQIKFRKSLPTQKRQKLSYKMPLYPLSSYFSLAFLVLVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
IMAYSEDTRIALIVGPIWLIGLAIVYYMKGFHKIDETPNSKIS
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]