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The map label for this gene is wecC [H]

Identifier: 118476194

GI number: 118476194

Start: 501385

End: 502629

Strand: Direct

Name: wecC [H]

Synonym: BALH_0443

Alternate gene names: 118476194

Gene position: 501385-502629 (Clockwise)

Preceding gene: 118476193

Following gene: 118476195

Centisome position: 9.54

GC content: 35.18

Gene sequence:

>1245_bases
ATGAATACTAGTCGTAAAGTAGCTATCATTGGATTAGGGTATGTTGGTCTTCCTTTAGCGGTCCATCTTGCAGAAAGGGG
CCATACTGTACTTGGATTAGATAAAGATACTAGAAAAATAGAATCAATTATAAAAGGAGAAAGTTATATTCCGGATGTTT
CTTCTAAATTGTTACAAAGTTTAGTGACGAAAAAAAAATTAATAGTAAATACACCGGATCAAGGTATTGCTGAGTTTCAA
AATAGTGATTATGTTATTGTCACTGTCCCGACTCCAATTAATGAACAAAGAGAACCAGACTTAAGTGCCCTCATTTCAGC
TTCACATTATATACAACAAAACCTTCAAAAAGGACAAACCTTCATTTTTGAAAGCTCCACCTATCCAGGTACACTCGAGG
AAGTTATCATTCCTATTATTTCTCAAACAGGTAAAAAGGCAGGAGAAGATTTCTATATCGGATATTCCCCTGAGAGAATT
GATCCAGCAAATAGTCAATATTCAGTTCAATCTATTCCAAAAGTTATTAGTGGACAAACAGAAAAGTGTAAACAAAAAGT
ACAGGCTTTGTATAGCACTATTTTTGATGTAGTTGTTCCAGTTAGTTCTCCGAAAGTAGCGGAGATGTGTAAGCTATTCG
AAAACATTCAGCGCCTAGTTAATATTTCGTTAGTCAATGAGCTAAACACACTATGTGAAAGTTTAGGAATTGATTTTTAT
GAGGCGCTTGAAGCGGCATCTACAAAACCATTTGGATTTACTCCATATTGGCCAGGTCCAGGGATAGGAGGACACTGTAT
TCCAGTAGACCCTTTATATTTTCAATGGAGAATAAAAAAGAATGGTGCAATGAGTCAATTGATTGAAGCAGCGCATGTAA
TTAATGAAGAAATGCCAGAGAAAATGGTCCAGAAAGTAAAAGGTGTGGTGCAACCACCTGCAACGGTTTTAATTGTAGGG
ATTGCATATAAGAAAGATGTAAATGACTTAAGAGAATCACCAGCGTTGCCAATTATTGAATTGTTAATAAAAGAAGGATA
CGAGATAGAATATCACGATCCATATATTTCTTCGGCAAAATTTGGAGATAAGGTGTATCAATCTGTTTCTTTGAATGAAC
AAGCCGTTAACCAAGCGAGTTGTATTTTAATTTTAACGGATCATTCTAATATTGATTGGAAGCTTTTTAAAGGAATAAAG
CAAGTAGTAGATACACGTGGGATTGTAAAGAAGGTGAGTAAATGA

Upstream 100 bases:

>100_bases
GCGTATTTATTACAATATACAGACGAACGCGGAGGTTTTACAGATGGAGATAGAGATAGAGAAATAATTCAACAATTGAG
AAGGGAAGAAGAGAATACAA

Downstream 100 bases:

>100_bases
GTAAGAAATGTTTAATTACAGGGGGAGCAGGATTTATTGGATCCCATTTAGCTGAAGAGTTGGTGGGAAGAGGTTATAAT
GTCACGATTGTTGATAACTT

Product: UDP-glucose/GDP-mannose dehydrogenase family protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNTSRKVAIIGLGYVGLPLAVHLAERGHTVLGLDKDTRKIESIIKGESYIPDVSSKLLQSLVTKKKLIVNTPDQGIAEFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERI
DPANSQYSVQSIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVG
IAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIK
QVVDTRGIVKKVSK

Sequences:

>Translated_414_residues
MNTSRKVAIIGLGYVGLPLAVHLAERGHTVLGLDKDTRKIESIIKGESYIPDVSSKLLQSLVTKKKLIVNTPDQGIAEFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERI
DPANSQYSVQSIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVG
IAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIK
QVVDTRGIVKKVSK
>Mature_414_residues
MNTSRKVAIIGLGYVGLPLAVHLAERGHTVLGLDKDTRKIESIIKGESYIPDVSSKLLQSLVTKKKLIVNTPDQGIAEFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERI
DPANSQYSVQSIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVG
IAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIK
QVVDTRGIVKKVSK

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=430, Percent_Identity=23.2558139534884, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=30.9302325581395, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=20.3856749311295, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=394, Percent_Identity=24.8730964467005, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136908, Length=400, Percent_Identity=25, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45896; Mature: 45896

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSRKVAIIGLGYVGLPLAVHLAERGHTVLGLDKDTRKIESIIKGESYIPDVSSKLLQS
CCCCCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHH
LVTKKKLIVNTPDQGIAEFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQT
HHHCCCEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
FIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERIDPANSQYSVQSIPKVISGQT
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCH
EKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPE
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
KMVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAK
HHHHHHHCCCCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHH
FGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKQVVDTRGIVKKVSK
HHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTSRKVAIIGLGYVGLPLAVHLAERGHTVLGLDKDTRKIESIIKGESYIPDVSSKLLQS
CCCCCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHH
LVTKKKLIVNTPDQGIAEFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQT
HHHCCCEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
FIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERIDPANSQYSVQSIPKVISGQT
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCH
EKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPE
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
KMVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAK
HHHHHHHCCCCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHH
FGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKQVVDTRGIVKKVSK
HHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]