Click here to switch to the map view.

The map label for this gene is ddl [H]

Identifier: 118475993

GI number: 118475993

Start: 243973

End: 245076

Strand: Direct

Name: ddl [H]

Synonym: BALH_0230

Alternate gene names: 118475993

Gene position: 243973-245076 (Clockwise)

Preceding gene: 118475992

Following gene: 118475994

Centisome position: 4.64

GC content: 36.5

Gene sequence:

>1104_bases
TTGGTTAGGGTGATTTCAGTGACAAAAATTAAATTAGGTTTATTATATGGTGGAAAATCAGCTGAGCATCAAGTTTCGTT
ACAAACGGCTCTTGCTGCTATTAAAGCATTAAATCAAGATAAATTCGAGATTCATCCAATTTATATTACAGAACAAGGTC
AATGGATACGCGGTGAACGTATTGAAGGTGAAGTAGCAAATGTTGAAGTTCTAAAAATGAGCGGTGCAGAAAATGCGATT
TCTCCGTTATCTTTAAGCACAGAAATCATTCCATCTGCAAATGCTGAGGAAAATGCTATCGACGTTATTTTCCCATTACT
ACATGGACCAAATGGTGAAGATGGAACGGTTCAAGGTTTATTAGAATTAATGAACATTCCTTATGTAGGAAATGGTGTTC
TAGCATCTGCTGCTGGTATGGATAAAGTTGTTATGAAAAACATTTTCGCAGAAGCTGGATTAAAACAAGCGAAATATGCA
TCATTCATTCGTAGCGGATGGGAAAAAGATCGTGAAACAGCATATGAAAAAGTAGAAGAAGTATTAGGATACCCTTGCTT
CGTAAAACCAGCAAACCTTGGTTCAAGTGTTGGGATTAATAAGTGTAAAAATCGTGAAGAGCTTGAGAATGCATTTGAAG
AGGCATTCCAATTTGACCGTAAAATTATTGTAGAAGAGAATATCATTGGACGTGAAGTAGAAGTTGGTGTACTAGGTAAT
GATGAACCGAAATGTTCAGTTGTAGGTGAAATCGTACCTAAAAAAGACTTCTATGATTATAAGTCGAAATACATCGATGG
TGATACAGCATTAATTATCCCAGCTGAAATGACAGAAGAAGAGTCTAATGTTATTAAGCGAGATGCGATTGTTGCCTTCC
AATCGTTAGATGGTGCTGGCTTAACGCGAGCTGATTTCTTCTTAACGAAAGATGGAGAAGTATATATTAACGAAGTGAAT
ACGATGCCAGGATTTACGCCGTTTAGTATGTTCCCTCTACTGTGGCAACATACTGGATTACCGTATCCGGAATTAATTGA
AGAGCTAATTCGTTTAGCAATGGAGCGTCACGAAGAAAAACAAAAAATTAAATATACAATCTAA

Upstream 100 bases:

>100_bases
AATAAGTGGTGTCATTTAATTATTTGTGGAAGTTACATTTTATTTCAAATAGGAACTACCTATTTTTATAAAAAGTGCTA
AAATAGAAAAATGAAAACAA

Downstream 100 bases:

>100_bases
CAAAAAAGGAGGAGGCACTATTCGCAGGAATAGTGCTTCCTCTATGTAAGGAGTGTTTTCATGATAAATCGAACGTTAAA
ACAAGTAGAACAAATGATAA

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MVRVISVTKIKLGLLYGGKSAEHQVSLQTALAAIKALNQDKFEIHPIYITEQGQWIRGERIEGEVANVEVLKMSGAENAI
SPLSLSTEIIPSANAEENAIDVIFPLLHGPNGEDGTVQGLLELMNIPYVGNGVLASAAGMDKVVMKNIFAEAGLKQAKYA
SFIRSGWEKDRETAYEKVEEVLGYPCFVKPANLGSSVGINKCKNREELENAFEEAFQFDRKIIVEENIIGREVEVGVLGN
DEPKCSVVGEIVPKKDFYDYKSKYIDGDTALIIPAEMTEEESNVIKRDAIVAFQSLDGAGLTRADFFLTKDGEVYINEVN
TMPGFTPFSMFPLLWQHTGLPYPELIEELIRLAMERHEEKQKIKYTI

Sequences:

>Translated_367_residues
MVRVISVTKIKLGLLYGGKSAEHQVSLQTALAAIKALNQDKFEIHPIYITEQGQWIRGERIEGEVANVEVLKMSGAENAI
SPLSLSTEIIPSANAEENAIDVIFPLLHGPNGEDGTVQGLLELMNIPYVGNGVLASAAGMDKVVMKNIFAEAGLKQAKYA
SFIRSGWEKDRETAYEKVEEVLGYPCFVKPANLGSSVGINKCKNREELENAFEEAFQFDRKIIVEENIIGREVEVGVLGN
DEPKCSVVGEIVPKKDFYDYKSKYIDGDTALIIPAEMTEEESNVIKRDAIVAFQSLDGAGLTRADFFLTKDGEVYINEVN
TMPGFTPFSMFPLLWQHTGLPYPELIEELIRLAMERHEEKQKIKYTI
>Mature_367_residues
MVRVISVTKIKLGLLYGGKSAEHQVSLQTALAAIKALNQDKFEIHPIYITEQGQWIRGERIEGEVANVEVLKMSGAENAI
SPLSLSTEIIPSANAEENAIDVIFPLLHGPNGEDGTVQGLLELMNIPYVGNGVLASAAGMDKVVMKNIFAEAGLKQAKYA
SFIRSGWEKDRETAYEKVEEVLGYPCFVKPANLGSSVGINKCKNREELENAFEEAFQFDRKIIVEENIIGREVEVGVLGN
DEPKCSVVGEIVPKKDFYDYKSKYIDGDTALIIPAEMTEEESNVIKRDAIVAFQSLDGAGLTRADFFLTKDGEVYINEVN
TMPGFTPFSMFPLLWQHTGLPYPELIEELIRLAMERHEEKQKIKYTI

Specific function: Cell wall formation [H]

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786579, Length=366, Percent_Identity=43.9890710382514, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1786280, Length=343, Percent_Identity=32.0699708454811, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185 [H]

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N [H]

EC number: =6.3.2.4 [H]

Molecular weight: Translated: 40782; Mature: 40782

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50975 ATP_GRASP ; PS00843 DALA_DALA_LIGASE_1 ; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVISVTKIKLGLLYGGKSAEHQVSLQTALAAIKALNQDKFEIHPIYITEQGQWIRGER
CEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCC
IEGEVANVEVLKMSGAENAISPLSLSTEIIPSANAEENAIDVIFPLLHGPNGEDGTVQGL
CCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHEEEEEHHCCCCCCCHHHHHH
LELMNIPYVGNGVLASAAGMDKVVMKNIFAEAGLKQAKYASFIRSGWEKDRETAYEKVEE
HHHHCCCCCCCCHHEHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGYPCFVKPANLGSSVGINKCKNREELENAFEEAFQFDRKIIVEENIIGREVEVGVLGN
HHCCCCEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECC
DEPKCSVVGEIVPKKDFYDYKSKYIDGDTALIIPAEMTEEESNVIKRDAIVAFQSLDGAG
CCCCEEEHHHHCCCCCHHHHHHHCCCCCEEEEEEHHHCCCHHHHHHHHHHHEEECCCCCC
LTRADFFLTKDGEVYINEVNTMPGFTPFSMFPLLWQHTGLPYPELIEELIRLAMERHEEK
CEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QKIKYTI
HHEECCC
>Mature Secondary Structure
MVRVISVTKIKLGLLYGGKSAEHQVSLQTALAAIKALNQDKFEIHPIYITEQGQWIRGER
CEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCC
IEGEVANVEVLKMSGAENAISPLSLSTEIIPSANAEENAIDVIFPLLHGPNGEDGTVQGL
CCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHEEEEEHHCCCCCCCHHHHHH
LELMNIPYVGNGVLASAAGMDKVVMKNIFAEAGLKQAKYASFIRSGWEKDRETAYEKVEE
HHHHCCCCCCCCHHEHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGYPCFVKPANLGSSVGINKCKNREELENAFEEAFQFDRKIIVEENIIGREVEVGVLGN
HHCCCCEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECC
DEPKCSVVGEIVPKKDFYDYKSKYIDGDTALIIPAEMTEEESNVIKRDAIVAFQSLDGAG
CCCCEEEHHHHCCCCCHHHHHHHCCCCCEEEEEEHHHCCCHHHHHHHHHHHEEECCCCCC
LTRADFFLTKDGEVYINEVNTMPGFTPFSMFPLLWQHTGLPYPELIEELIRLAMERHEEK
CEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QKIKYTI
HHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA