Click here to switch to the map view.

The map label for this gene is cysG [H]

Identifier: 117919889

GI number: 117919889

Start: 1669846

End: 1670757

Strand: Direct

Name: cysG [H]

Synonym: Shewana3_1441

Alternate gene names: 117919889

Gene position: 1669846-1670757 (Clockwise)

Preceding gene: 117919888

Following gene: 117919890

Centisome position: 33.58

GC content: 53.51

Gene sequence:

>912_bases
ATGCAATATTTCCCGCTGTTTATTGATACTGTGAATTTAAATGTCCTGTTAGTGGGGGCGGGGGATGTTGCCAGTCGTAA
GCTGGCTTTGCTGACGCGTACCGAAGCCAATATCCATGTGATTGCCCCCGAGGTGAATCCCGAGGTAAAGGCCTATGCCG
ATGCAGGCAGGATTTTATTGTCTGAGCGGCCCGTGGTGCAGGCCGATATTCAAAATTACGATCTCATTTATTTAGCGACC
GCGAACGATAAGCTCAATGCTGAATTAGCCACCTTAGCTACCGAGCGGGGAATTTGGGTCAATGCCGTGGATAATCCCGC
CTATTGCCGCTTTATTACCCCATCGATTGTCGATAGGGGACGTCTTGTGGTGGCGATCAGCACTGCGGGTGCAGCGCCTG
TGTTTGCGCGCACCATTCGAGCTCGTTTAGAGACCAGCCTGCCGCAATCGCTTAAGCCCTTGTTTGACTTTGTGGCCGAC
AAGCGTCTCGAAGTGCAGCAAAGACTCACTAAAACCGCGACGCGCCGATTATTCTGGGAACGCTTTTTCGACACCAATGG
CGATAGATTTGATGCGCGAACCCCCGAGCATTATCAGAATGCTTTTAACCATATCGTCAGCCGCGGGGAAATCCTGTTAT
TGGACGATGCTACGCCCGTCGAGTTATTGCCGCTGGCGGCCATGCCGTTATTACAGCGCCTCGATTGGATTTACAGCGAA
GCAGGTTTAGCCGAGGACTTGGCCGAGCTGGTGCGCCGCGATGCTAATCGTGCAGCGCTTCCCGCGCTGAGTGATATCAG
CCGGGAATATGAGCAAGGCTCGCGGATGTTGTTGGTCGCCGATACCCAGAAGATTGCGCAACTTAAGGCGCATTTCCCGG
TGGCGAAGCATTTACGCCCCGGCGCGATTTAG

Upstream 100 bases:

>100_bases
GTCGCCTCCTTGATTGGTGGTTACAAGGGCTGGATCCAACGCCAGTTACCCGTGGTGCAAGAGTAATTTAGGCTGGTTTT
ACTTTTTATAGGCGAGTGGC

Downstream 100 bases:

>100_bases
TCTTCTTTATCGCAGTTTGTTTGAGCTGACGGCGAGTCTTAGGTAGACTCGCCGTTATTTTTTTATCGTTAAGTTTAGGA
TGTACTATGGCTCTCAAAGC

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MQYFPLFIDTVNLNVLLVGAGDVASRKLALLTRTEANIHVIAPEVNPEVKAYADAGRILLSERPVVQADIQNYDLIYLAT
ANDKLNAELATLATERGIWVNAVDNPAYCRFITPSIVDRGRLVVAISTAGAAPVFARTIRARLETSLPQSLKPLFDFVAD
KRLEVQQRLTKTATRRLFWERFFDTNGDRFDARTPEHYQNAFNHIVSRGEILLLDDATPVELLPLAAMPLLQRLDWIYSE
AGLAEDLAELVRRDANRAALPALSDISREYEQGSRMLLVADTQKIAQLKAHFPVAKHLRPGAI

Sequences:

>Translated_303_residues
MQYFPLFIDTVNLNVLLVGAGDVASRKLALLTRTEANIHVIAPEVNPEVKAYADAGRILLSERPVVQADIQNYDLIYLAT
ANDKLNAELATLATERGIWVNAVDNPAYCRFITPSIVDRGRLVVAISTAGAAPVFARTIRARLETSLPQSLKPLFDFVAD
KRLEVQQRLTKTATRRLFWERFFDTNGDRFDARTPEHYQNAFNHIVSRGEILLLDDATPVELLPLAAMPLLQRLDWIYSE
AGLAEDLAELVRRDANRAALPALSDISREYEQGSRMLLVADTQKIAQLKAHFPVAKHLRPGAI
>Mature_303_residues
MQYFPLFIDTVNLNVLLVGAGDVASRKLALLTRTEANIHVIAPEVNPEVKAYADAGRILLSERPVVQADIQNYDLIYLAT
ANDKLNAELATLATERGIWVNAVDNPAYCRFITPSIVDRGRLVVAISTAGAAPVFARTIRARLETSLPQSLKPLFDFVAD
KRLEVQQRLTKTATRRLFWERFFDTNGDRFDARTPEHYQNAFNHIVSRGEILLLDDATPVELLPLAAMPLLQRLDWIYSE
AGLAEDLAELVRRDANRAALPALSDISREYEQGSRMLLVADTQKIAQLKAHFPVAKHLRPGAI

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=268, Percent_Identity=34.7014925373134, Blast_Score=142, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYFPLFIDTVNLNVLLVGAGDVASRKLALLTRTEANIHVIAPEVNPEVKAYADAGRILL
CCEEEEEEEEECEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCEEHHCCCEEEE
SERPVVQADIQNYDLIYLATANDKLNAELATLATERGIWVNAVDNPAYCRFITPSIVDRG
CCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCEEEEECHHHHCCC
RLVVAISTAGAAPVFARTIRARLETSLPQSLKPLFDFVADKRLEVQQRLTKTATRRLFWE
EEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RFFDTNGDRFDARTPEHYQNAFNHIVSRGEILLLDDATPVELLPLAAMPLLQRLDWIYSE
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AGLAEDLAELVRRDANRAALPALSDISREYEQGSRMLLVADTQKIAQLKAHFPVAKHLRP
CCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCHHHCCCC
GAI
CCC
>Mature Secondary Structure
MQYFPLFIDTVNLNVLLVGAGDVASRKLALLTRTEANIHVIAPEVNPEVKAYADAGRILL
CCEEEEEEEEECEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCEEHHCCCEEEE
SERPVVQADIQNYDLIYLATANDKLNAELATLATERGIWVNAVDNPAYCRFITPSIVDRG
CCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCEEEEECHHHHCCC
RLVVAISTAGAAPVFARTIRARLETSLPQSLKPLFDFVADKRLEVQQRLTKTATRRLFWE
EEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RFFDTNGDRFDARTPEHYQNAFNHIVSRGEILLLDDATPVELLPLAAMPLLQRLDWIYSE
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AGLAEDLAELVRRDANRAALPALSDISREYEQGSRMLLVADTQKIAQLKAHFPVAKHLRP
CCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCHHHCCCC
GAI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA