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The map label for this gene is holC [H]

Identifier: 117919581

GI number: 117919581

Start: 1336930

End: 1337394

Strand: Reverse

Name: holC [H]

Synonym: Shewana3_1132

Alternate gene names: 117919581

Gene position: 1337394-1336930 (Counterclockwise)

Preceding gene: 117919582

Following gene: 117919580

Centisome position: 26.9

GC content: 45.59

Gene sequence:

>465_bases
ATGACTCAAGCGCTGTTTTATTTACTGCCGCCGATGGGCGTGAACACGGCCCTTAATGACATGTATCAATTAGCTTGCCG
TCTAGCCCAACAGGGATTTATAAACCAGCAGCAGGTCTATATTCACTGTCAGGACAAGAACATCGCCTTCGAAATCGACG
AGTTACTATGGCAGTTTGAACCCAGTGCATTTGTCCCCCATAACCTCAAAGGTGAAGGCCCCACTACTGGCTCACCCGTT
GAAATCGGTTTTGACAGACTCGGCCCAAACAAAAGTCGCCAACTTCTGATTAATCTTGCAGACCAAGTGCCTCCGTTTGC
GGTAAACTTTGGTCAAATCTTCGATTTTGTGGCTAATGACGACCAACATAAAGCGATAGCACGTGAACGCTATCGCCAAT
ATCGTGGCTTAGGGATTGAATTAACAACCCAAAATTTAGCAACACATCCACTTAATTTAGCTTGA

Upstream 100 bases:

>100_bases
CAAGCTCCCGTGAAAAACCCCGATGCTAAGCGTTAACCCCGCTTGAGTTTTAGTGTAAACTTACCCGTTCGTCTATAACT
TAAAGCAAGGCATTGAAATC

Downstream 100 bases:

>100_bases
GACAGATACGTTCCCATGGAAAAAACATACGATCCTCAGTCCATTGAGCAGACTCTTTACCAAAACTGGGAAGAGCAAGG
TTACTTTAAGCCCCACGGCG

Product: DNA polymerase III chi subunit, HolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTQALFYLLPPMGVNTALNDMYQLACRLAQQGFINQQQVYIHCQDKNIAFEIDELLWQFEPSAFVPHNLKGEGPTTGSPV
EIGFDRLGPNKSRQLLINLADQVPPFAVNFGQIFDFVANDDQHKAIARERYRQYRGLGIELTTQNLATHPLNLA

Sequences:

>Translated_154_residues
MTQALFYLLPPMGVNTALNDMYQLACRLAQQGFINQQQVYIHCQDKNIAFEIDELLWQFEPSAFVPHNLKGEGPTTGSPV
EIGFDRLGPNKSRQLLINLADQVPPFAVNFGQIFDFVANDDQHKAIARERYRQYRGLGIELTTQNLATHPLNLA
>Mature_153_residues
TQALFYLLPPMGVNTALNDMYQLACRLAQQGFINQQQVYIHCQDKNIAFEIDELLWQFEPSAFVPHNLKGEGPTTGSPVE
IGFDRLGPNKSRQLLINLADQVPPFAVNFGQIFDFVANDDQHKAIARERYRQYRGLGIELTTQNLATHPLNLA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=143, Percent_Identity=39.8601398601399, Blast_Score=115, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 17432; Mature: 17301

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQALFYLLPPMGVNTALNDMYQLACRLAQQGFINQQQVYIHCQDKNIAFEIDELLWQFE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHCC
PSAFVPHNLKGEGPTTGSPVEIGFDRLGPNKSRQLLINLADQVPPFAVNFGQIFDFVAND
CCCCCCCCCCCCCCCCCCCEEECHHCCCCCCCHHEEEEHHHCCCCCEECHHHHHHHHCCC
DQHKAIARERYRQYRGLGIELTTQNLATHPLNLA
CHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TQALFYLLPPMGVNTALNDMYQLACRLAQQGFINQQQVYIHCQDKNIAFEIDELLWQFE
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHCC
PSAFVPHNLKGEGPTTGSPVEIGFDRLGPNKSRQLLINLADQVPPFAVNFGQIFDFVAND
CCCCCCCCCCCCCCCCCCCEEECHHCCCCCCCHHEEEEHHHCCCCCEECHHHHHHHHCCC
DQHKAIARERYRQYRGLGIELTTQNLATHPLNLA
CHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8389364; 8246893; 7610040; 9278503; 2670557; 8505305; 1575709 [H]